Cyproheptadine May Prevent And Treat HIV Infection

Discussion in 'Scientific Studies' started by haidut, Mar 9, 2016.

  1. haidut

    haidut Member

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    A few months ago I posted a study showing cyproheptadine being potentially effective against Ebola and rabies viruses.
    Cyproheptadine may treat Ebola infection

    In another study, it was shown that the serotonin receptor is vital for infection and replication with viruses like JCV.
    The JCV uses a serotonin receptor to infect cells

    Now, this study adds to the evidence implicating serotonin in viral pathologies, and shows that cyproheptadine can both block infection and inhibit established infection with HIV. In higher doses, cyproheptadine completely eradicated the virus. The other compounds the study found effective all had cytotoxicity, while cyproheptadine did not, even in very high doses.

    Bioavailable inhibitors of HIV-1 RNA biogenesis identified through a Rev-based screen. - PubMed - NCBI

    "...In conclusion, by screening one thousand FDA-approved drugs according to their ability to displace Rev 34–50 from its RRE subdomain IIB site, we have identified two bioavailable drugs, clomiphene and cyproheptadine, that are capable of inhibiting the post-integration stage of HIV-1. Both compounds bound to RRE subdomain IIB and blocked RRE–Rev complex formation at low lM concentrations similar to their cellular EC50 values, and RNA loop IIB recognition by clomiphene was substantially specific. Remarkably, no antiretroviral activity and no nucleic acid binding had been previously reported for these two agents. Although the anti-HIV activities of both drugs were apparently dominated by inhibition of LTR-dependent transcription, the observed blockage of RRE–Rev binding may also contribute to their antiviral effect. For clomiphene, this mechanism was supported by the detection of changes of HIV-1 splicing patterns consistent with Rev inhibition. In this regard, these hits have defined a new RNA-binding and RRE–Rev inhibition motif that may serve as a starting point for the development of HIV-1 gene-regulation inhibitors."
     
  2. TubZy

    TubZy Member

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    Since everyone is going crazy for anti viral strategies lately..I'm bumping this thread lol
     
  3. GAF

    GAF Member

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    What about Hep C?

    Any reason the results would be different for that virus?
     
  4. pimpnamedraypeat

    pimpnamedraypeat Member

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    Would this be effective for herpes?

    If not, is there a peat approved treatment for herpes
     
  5. jyb

    jyb Member

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    L-Lysine is pretty popular on this forum. It turns out herpes is possibly the top reason why people supplement it, judging by Lysine online supplement reviews.
     
  6. TubZy

    TubZy Member

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    Most likely due to inhibition of NO since arginine is the precursor to NO and viruses use NO to replicate, plus the serotonin antagonism lysine provides
     
  7. passivity

    passivity Member

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  8. pimpnamedraypeat

    pimpnamedraypeat Member

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    Interesting. I have high NO. Lean and very veiny. I have noticed my vascularity is syncronized with the itchiness from herpes.

    thnak you
     
  9. John Estrada

    John Estrada Member

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    Do you know the dose and duration of cypro used to completely eradicated the virus? Could metergoline be used as an alternative with a comparable dose?
     
  10. OP
    haidut

    haidut Member

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    "...MT-2 cells were transfected with a pNL4.3 plasmid and treated with two different concentrations of clomiphene (5 and 10 lM) or cyproheptadine (5 and 50 lM) for 72 or 96 h."

    Since the study found the IC50 concentration of cyrpoheptadine to be in the range of 1.5-4.2 uM/L in regards to various viral replication/viability parameters that means doses in the range of 4mg-16mg for up to 4 days. For some people with impaired intestinal absorption even higher doses may be needed and clinically cypro is considered OK to use in doses up to 32mg daily for severe cases such as inoperable Cushing syndrome or severe serotonin syndrome.
     
  11. Waynish

    Waynish Member

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    Misleading. HIV is a material from cell decay. People test positive more often with the flu, while they're pregnant, etc - and EM tests (the very very few who get them) come back negative. So these antibodies are non-specific.

    But sure, someone "diagnosed with HIV" might benefit from cyproheptadine - depending upon their physiology.
     
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