Insulin Resistance Correlate With High T3 (bs?)

[zane93]

Insulin Resistance Correlate with High T3 and High T3 Many Induce Insulin Resistance
I have searched for some RP comments on this and cannot find any so I am figuring that it is BS or I did not search properly.

I just started on T3 only on Monday and as of 5 months ago I had good Hemoglobin Alc at 5.3 consistent with the absence of diabetes according to the lab. Not over weight and no smoking or drinking.

So to night I had some carbs gluten free noodles, egg plant, and some tomato sauce. Almost immediately after I finished eating I felt very tired, run down, and both of my kidneys hurt. I checked my 5 min resting pulse the range was 67-73 and my temp was 98.0 and that is better than previous to T3 only at 97.4. Because my pulse and temp where ok but not perfect I did not think that it was quite dosing time and something else was at play.

Sorry if this is a stupid questions but I did not know if their was any validity to what this site/lady was saying that "High T3 Many Induce Insulin Resistance".

Probably just hypo paranoia lol...

Some more of what she is said..
"Since insulin resistance is affected by thyroid hormone levels, a comparison was made between the T3/rT3 ratios of insulin resistant and insulin sensitive subjects. The T3/rT3 ratio was significantly higher in insulin resistant subjects, who had a higher proportion of T3 to rT3. [9] Since a high ratio is actually the goal of the T3-only protocol, and quite a few on the protocol notice their blood glucose rising, one might ask if the protocol itself is inducing the insulin resistance.

A suppressed TSH (below the reference range or close to zero) is also correlated with higher insulin levels, insulin resistance, and lower insulin sensitivity when compared to control subjects, even though Free T4 and T3 may be within the reference range. Insulin resistance, as measured by HOMA-IR, showed a positive relationship with T3 levels throughout the whole sample population of both controls and those on thyroid replacement. In other words, as T3 rose, so did insulin resistance."

 

[DaveFoster]

T3 can raise adrenaline. Adrenaline leads to FFA elevation, which leads to insulin resistance.

 

[zane93]

T3 can raise adrenaline. Adrenaline leads to FFA elevation, which leads to insulin resistance.

I had a higher than "normal" RT3 levels and have no thyroid. Do you think that only after a two days of T3 only that T3 can drive down RT3 levels that fast and cause an imbalance as stated? What does FFA stand for free fatty acids?

If the above is true I find it quite amazing that I could develop an insulation resistance in the matter of days when I had a very good sensitivity.

I went back to my Synthroid and NDT and have not had that experience again but I am slightly hypo. I’m going to wait another couple of weeks and test my thyroid levels again. I believe I will stay on Synthroid NDT and try adding a little T3 to the mix to see if I can get out of this hypo slump.

 

[DaveFoster]

I had a higher than "normal" RT3 levels and have no thyroid. Do you think that only after a two days of T3 only that T3 can drive down RT3 levels that fast and cause an imbalance as stated? What does FFA stand for free fatty acids?

If the above is true I find it quite amazing that I could develop an insulation resistance in the matter of days when I had a very good sensitivity.

I went back to my Synthroid and NDT and have not had that experience again but I am slightly hypo. I’m going to wait another couple of weeks and test my thyroid levels again. I believe I will stay on Synthroid NDT and try adding a little T3 to the mix to see if I can get out of this hypo slump.

You should take NDT and increase by 1/16 every week. Start at 1/16.

 

[Giraffe]

@zane93 , what makes you think that you are/were insulin resistant?

 

[zane93]

@zane93 , what makes you think that you are/were insulin resistant?

I really did not think I was insulin resistant but I never felt like that nor could I relate to what insulin resistance feels like. In fact my blood tests 5 months earlier showed good sensitivity. I felt ok before eating then about two mins after it was like a truck hit me in the face. So went fishing for relevant info about my then current new t3 path when I happen to run across that site talking about "Insulin Resistance Correlate With High T3" I came here to get some input to see if there was any truth to it.

Looking back on it I still have no idea what was going on and hope it does not happen again.

 

[ddjd]

T3 prescriptions make insulin resistance worse - The Blood Code

T3 prescriptions are likely making your insulin resistance worse.

www.thebloodcode.com

It is so easy fall in to the trap of prescriptions, especially with thyroid hormones.

Thyroid hormone regulates your cellular resting metabolism. T3 is the active thyroid hormone. Therefore More T3 promotes “more metabolism”. Sounds alluring right? My prescription pad is ready, but wait.

For every action, you body responds with a greater and compensatory reaction. If there is an exogenous T3 (Introduced from outside the body) taken, you body will store more and trigger the ever-important insulin resistance so you do not burn out. Your body will also de-activate the very hormone that you just took – you can’t fool mother nature that easily. Let me explain.

As a metabolic specialist, I am tempted to offer a T3 prescription to more people when headlines like this appear,

“Low T3 with higher T4 is associated with those with Inulin resistance and T2DM”. Add T3 and I’ll presumably improve this ratio, furthermore the active T3 will go up.
[Farasat T, et al. Hyperinsulinemia and insulin resistance is associated with low T(3)/T(4) ratio in pre diabetic euthyroid pakistani subjects. J Diabetes Complications. 2012 JUL;26(6) 522-525.]

But a high T3/rT3 ratio directly correlates with greater insulin resistance measured by the HOMA-IR.
[Ruhla S, et al. T3/rT3-ratio is associated with insulin resistance independent of TSH. Horm Metab Res. 2011 Feb;43(2):130-4.]

The addition of T3 prescription (Cytomel is the brand name for liothyronine, or T3) has a dose dependent trigger toward insulin resistance. The more you take, the worse your insulin resistance becomes. This is no small finding that only affects a few people, significance was found throughout several small T3 dosages in the studies.
[Lambadiari V, et al. Thyroid hormones are positively associated with insulin resistance early in the development of type 2 diabetes. Endocrine. 2011 Feb;39(1):28-32.]

Why does this all happen? – When we prescribers add T3 prescriptions, T3 numbers and ratios actually get worse, and we are likely contributing to a worsening of damaging insulin resistance. The truth is, the DIO enzymes regulate glucose homeostasis and insulin sensitivity and they are locally controlled throughout your body.

[Chidakel A, et al. Peripheral metabolism of thyroid hormone and glucose homeostasis. Thyroid 2005 Aug;15(8):899-903.]

I have a take home message, and part of it is in response to the humble pie I had to take when I realized that my prescriptions made some people worse. – If you are told by a doctor that you should take a T3 prescription, assure that you have properly evaluated for insulin resistance first. You can do this by checking a fasting glucose and insulin. Use the calculator to run the number. If you have a high glucose or high HgbA1c, you already know that insulin resistance is a showing. The T3 prescription will likely make you worse.

You can take the step toward reading the owners manual for your body’s metabolism, it is called The Blood Code.

 

[hei]

T3 prescriptions make insulin resistance worse - The Blood Code

T3 prescriptions are likely making your insulin resistance worse.

www.thebloodcode.com

It is so easy fall in to the trap of prescriptions, especially with thyroid hormones.

Thyroid hormone regulates your cellular resting metabolism. T3 is the active thyroid hormone. Therefore More T3 promotes “more metabolism”. Sounds alluring right? My prescription pad is ready, but wait.

For every action, you body responds with a greater and compensatory reaction. If there is an exogenous T3 (Introduced from outside the body) taken, you body will store more and trigger the ever-important insulin resistance so you do not burn out. Your body will also de-activate the very hormone that you just took – you can’t fool mother nature that easily. Let me explain.

As a metabolic specialist, I am tempted to offer a T3 prescription to more people when headlines like this appear,

“Low T3 with higher T4 is associated with those with Inulin resistance and T2DM”. Add T3 and I’ll presumably improve this ratio, furthermore the active T3 will go up.
[Farasat T, et al. Hyperinsulinemia and insulin resistance is associated with low T(3)/T(4) ratio in pre diabetic euthyroid pakistani subjects. J Diabetes Complications. 2012 JUL;26(6) 522-525.]

But a high T3/rT3 ratio directly correlates with greater insulin resistance measured by the HOMA-IR.
[Ruhla S, et al. T3/rT3-ratio is associated with insulin resistance independent of TSH. Horm Metab Res. 2011 Feb;43(2):130-4.]

The addition of T3 prescription (Cytomel is the brand name for liothyronine, or T3) has a dose dependent trigger toward insulin resistance. The more you take, the worse your insulin resistance becomes. This is no small finding that only affects a few people, significance was found throughout several small T3 dosages in the studies.
[Lambadiari V, et al. Thyroid hormones are positively associated with insulin resistance early in the development of type 2 diabetes. Endocrine. 2011 Feb;39(1):28-32.]

Why does this all happen? – When we prescribers add T3 prescriptions, T3 numbers and ratios actually get worse, and we are likely contributing to a worsening of damaging insulin resistance. The truth is, the DIO enzymes regulate glucose homeostasis and insulin sensitivity and they are locally controlled throughout your body.

[Chidakel A, et al. Peripheral metabolism of thyroid hormone and glucose homeostasis. Thyroid 2005 Aug;15(8):899-903.]

I have a take home message, and part of it is in response to the humble pie I had to take when I realized that my prescriptions made some people worse. – If you are told by a doctor that you should take a T3 prescription, assure that you have properly evaluated for insulin resistance first. You can do this by checking a fasting glucose and insulin. Use the calculator to run the number. If you have a high glucose or high HgbA1c, you already know that insulin resistance is a showing. The T3 prescription will likely make you worse.

You can take the step toward reading the owners manual for your body’s metabolism, it is called The Blood Code.

The message I get from this is that if you have an impaired metabolism it's futile to even try to fix anything.

 

[Wayne J]

Well, with no thyroid due to 7 weeks of throat radiation plus am already T2 dibaetic - fasting glucose ( use 1500 Berberine 3x day) of brtween 112 - 126, it looks like I can kiss off the T3...
TSH .54 but RT3 13 and T3 is low mid range. - have numerous hypo symtoms - overweight, constipation, moody, low metabolism.
UGH