Hypothyroid State Reduces AR Expression And 5-ar

[bdawg]

On the flipside, not sure if the hyperthyroid state means enhanced expression.....

"Male pups with transient gestational hypothyroidism showed subnormal levels of serum testosterone, and estradiol, along with decreased expression of Ar, and 5α-reductase activity in the epididymis of pre-puberal rats at postnatal day"

http://www.informaticsjournals.com/index.php/jer/article/view/15745

 

[TubZy]

On the flipside, not sure if the hyperthyroid state means enhanced expression.....

"Male pups with transient gestational hypothyroidism showed subnormal levels of serum testosterone, and estradiol, along with decreased expression of Ar, and 5α-reductase activity in the epididymis of pre-puberal rats at postnatal day"

http://www.informaticsjournals.com/index.php/jer/article/view/15745

My question is we know it can enhance 5AR in the endocrine system but what about brain/nervous system? I assume since T3 crosses the BBB it can?

 

[Abc123]

I'am hypothyroid and my DHEA and DHT is very low. I have heard that Hyperthyroid patients do have excessive DHT

 

[Jsaute21]

My question is we know it can enhance 5AR in the endocrine system but what about brain/nervous system? I assume since T3 crosses the BBB it can?

@haidut any thoughts on this?

 

[haidut]

@haidut any thoughts on this?

Yes, it crosses the BBB and should affect 5-AR in the brain as well. I don't think T3 is selective in terms of where it boosts 5-AR activity.