Estrogen Lowers T, DHT, And Fertility; Inhibits 5α-Reductase (5-AR)

haidut

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I am posting this study below as a response to numerous angry emails I have been getting over the years. People sending me those emails just cannot accept the idea that estrogen can be detrimental for males (and females as well), and that estrogen levels are directly antagonistic to the male phenotype. This "'male antagonism" of estrogen is one of the main reasons it was approved back in the 1960s as "treatment" for prostate cancer. Yet, myths about its "benefits" in males persist, not only among athletes/bodybuilders but also in medical circles. One of the claims of "benefit" of estrogen is that it induces the enzyme 5-AR and somehow increases androgenic tone, with the role of estrogen to "balance" the androgenicity it itself induces. This is the so-called contrarian endocrinology, which seems to have affected even the community of Peat followers over the last few years despite no evidence for any of these claims. To the contrary, I recently did a post demonstrating that estrogen is NOT needed even for male sexual function, and the claim linking estrogen with sexuality is perhaps the main reason for people to defend estrogen when it comes to male health. There is also evidence that estrogen is NOT needed neither for bone nor for muscle development. In reality, the evidence so far points to the following - similarly to prolactin, if a male's estrogen (mostly E2, but E1 and E3 matter too) levels are in the upper 50% of the "normal" range defined for males by mainstream medicine, then that male's health will be poor. That includes not only sexual/reproductive but also mental, physiological, and thus systemic health.

Downregulation of testosterone production through luteinizing hormone receptor regulation in male rats exposed to 17α-ethynylestradiol | Scientific Reports

"...The pharmaceutical 17α-ethynylestradiol (EE2) is considered as an endocrine-disrupting chemical that interferes with male reproduction and hormonal activation. In this study, we investigated the molecular mechanism underlying EE2-regulatory testosterone release in vitro and in vivo. The results show that EE2 treatment decreased testosterone release from rat Leydig cells. Treatment of rats with EE2 reduced plasma testosterone levels and decreased the sensitivity of human chorionic gonadotropin (hCG). EE2 reduced luteinizing hormone receptor (LHR) expression associated with decreased cAMP generation by downregulation of adenylyl cyclase activity and decreased intracellular calcium-mediated pathways. The expression levels of StAR and P450scc were decreased in Leydig cells by treatment of rats with EE2 for 7 days. The sperm motility in the vas deferens and epididymis was reduced, but the histopathological features of the testis and the total sperm number of the vas deferens were not affected. Moreover, the serum dihydrotestosterone (DHT) level was decreased by treatment with EE2. The prostate gland and seminal vesicle atrophied significantly, and their expression level of 5α-reductase type II was reduced after EE2 exposure. Taken together, these results demonstrate an underlying mechanism of EE2 to downregulate testosterone production in Leydig cells, explaining the damaging effects of EE2 on male reproduction."
 

jtoro

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Feb 4, 2018
Messages
59
Taking androsterone has crushed my libido.
1 mg daily for a month or so. With panterone
Then I ran out of pansterone
So androsterone
Then 2mg for a couple of days.
Then 5mg for a couple of days.


Nothing over 5mg.
This product is quite scary.
Please advise.
 

jzone56

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Joined
Jan 28, 2020
Messages
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Taking androsterone has crushed my libido.
1 mg daily for a month or so. With panterone
Then I ran out of pansterone
So androsterone
Then 2mg for a couple of days.
Then 5mg for a couple of days.


Nothing over 5mg.
This product is quite scary.
Please advise.

when you say, “crushed my libido” what do you mean?
 

Mauritio

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Joined
Feb 26, 2018
Messages
2,392
I went from wanting to have sex to zero desire to have sex
I have experienced the same. Even 1mg daily does that . It even gets hard to maintain an erection .
Let me preface that I dont subscribe to the too low estrogen/ estrogen is healthy believe . But androsterone must lower something beneficial . My best guess would be progesterone ,since other aromatase inhibiters have been shown to lower progesterone iirc.
I even experienced the much talked about joint pain . Bad timing that I was on a 3 weeks trip in the Nepalese mountains... I suffered from excruciating pain in my knees it only got a little better when stopped taking andro . Pregnenolone helped a little , ginger tea helped a lot .
 

jtoro

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Joined
Feb 4, 2018
Messages
59
I have experienced the same. Even 1mg daily does that . It even gets hard to maintain an erection .
Let me preface that I dont subscribe to the too low estrogen/ estrogen is healthy believe . But androsterone must lower something beneficial . My best guess would be progesterone ,since other aromatase inhibiters have been shown to lower progesterone iirc.
I even experienced the much talked about joint pain . Bad timing that I was on a 3 weeks trip in the Nepalese mountains... I suffered from excruciating pain in my knees it only got a little better when stopped taking andro . Pregnenolone helped a little , ginger tea helped a lot .

Are you back to "normal"?
 

dand

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Joined
Jul 3, 2014
Messages
221
Taking androsterone has crushed my libido.
1 mg daily for a month or so. With panterone
Then I ran out of pansterone
So androsterone
Then 2mg for a couple of days.
Then 5mg for a couple of days.


Nothing over 5mg.
This product is quite scary.
Please advise.
Have had similar experiences before and think it is from the pro metabolic nature of things like andro/dht etc. Meaning you’re becoming nutrient deplete bc of increased metabolic rate. Try eggs, oyster, liver
 

Mauritio

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Joined
Feb 26, 2018
Messages
2,392
Are you back to "normal"?
Yeah I'm long back to normal . I just stopped taking androsterone . I still wonder what this was . Could the body builders be right that theres a healthy amount of estrogen needed for some things ? Reading peats work ,makes you think that too low estrogen is almost impossible.
I think he said under some circumstances one of the arm veins became the main estrogen producer.
 

dand

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Joined
Jul 3, 2014
Messages
221
Yeah I'm long back to normal . I just stopped taking androsterone . I still wonder what this was . Could the body builders be right that theres a healthy amount of estrogen needed for some things ? Reading peats work ,makes you think that too low estrogen is almost impossible.
I think he said under some circumstances one of the arm veins became the main estrogen producer.
I’m not sure quite frankly. I’ve been experimenting w 11keto dht lately and just have to make sure nutrition is good n take a little cortinon every once in a while.
 
Joined
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Messages
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I think he said under some circumstances one of the arm veins became the main estrogen producer.
Do you remember where he said that?
 

Tash

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Joined
Dec 14, 2019
Messages
21
Have been slipping a few drops of pansterone into my husband's freshly squeezed morning oj - no complaints 😀
 
Joined
Jun 16, 2017
Messages
1,663
Oh boy , in one of his countless interviews... It was a more recent one or at least not older than a year .

Edit: I found it, thanks to bioenergetic.life
1:15:50
Thanks! And I have bioenergetic.life bookmarked. I should definitely use it more. Really good resource!
 
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