mandance
Member
- Joined
- Jul 5, 2013
- Messages
- 473
Ive been talking with Peat about antidepressants recently...as that is the ordeal I am facing, and also trying to help people in some other communitys deal with understanding them more. When I asked Peat whether or not long term anti depressant use causes permanent brain damage, he simply linked this study
Physiol Behav. 2006 Jan 30;87(1):114-9.
Peripheral triiodothyronine (T(3)) levels during escapable and inescapable
footshock.
Helmreich DL, Crouch M, Dorr NP, Parfitt DB.
Department of Biology and Program of Neuroscience, Middlebury College,
Middlebury, VT 05753, USA. [email protected]
Changes in peripheral thyroid hormone levels are associated with changes in human
affective disorders, particularly depression. In the current study we used an
animal stress paradigm, proposed to be an animal model of depression, to examine
peripheral T(3) levels during and after escapable or inescapable stress in adult
male rats. In this model, one animal can control the termination of foot-shock
stress by performing a lever press, and therefore experiences escapable stress.
His lever press also terminates the shock for his yoked partner, who has no
control over the stressor, and therefore experiences inescapable stress. In three
separate experiments, blood samples were collected during and after one or two
sessions of escapable/inescapable stress. We found that exposure to inescapable
stress, but not escapable stress, caused a decrease in T(3) levels 120 min
post-stress initiation. Peripheral T(3) levels were not significantly altered in
animals exposed to escapable stress. In sum, these results add to a large body of
previous data indicating that psychological coping can prevent the effects of
physical stress on many diverse systems.
Id like to get some opinions of the community on this in what exactly it might mean...I have a few ideas but I know that there are members here who probably could provide some valid insights. Thanks I will also post this in the depository for our records.
Physiol Behav. 2006 Jan 30;87(1):114-9.
Peripheral triiodothyronine (T(3)) levels during escapable and inescapable
footshock.
Helmreich DL, Crouch M, Dorr NP, Parfitt DB.
Department of Biology and Program of Neuroscience, Middlebury College,
Middlebury, VT 05753, USA. [email protected]
Changes in peripheral thyroid hormone levels are associated with changes in human
affective disorders, particularly depression. In the current study we used an
animal stress paradigm, proposed to be an animal model of depression, to examine
peripheral T(3) levels during and after escapable or inescapable stress in adult
male rats. In this model, one animal can control the termination of foot-shock
stress by performing a lever press, and therefore experiences escapable stress.
His lever press also terminates the shock for his yoked partner, who has no
control over the stressor, and therefore experiences inescapable stress. In three
separate experiments, blood samples were collected during and after one or two
sessions of escapable/inescapable stress. We found that exposure to inescapable
stress, but not escapable stress, caused a decrease in T(3) levels 120 min
post-stress initiation. Peripheral T(3) levels were not significantly altered in
animals exposed to escapable stress. In sum, these results add to a large body of
previous data indicating that psychological coping can prevent the effects of
physical stress on many diverse systems.
Id like to get some opinions of the community on this in what exactly it might mean...I have a few ideas but I know that there are members here who probably could provide some valid insights. Thanks I will also post this in the depository for our records.