Comparison of the Metabolic Stimulating Action of Aspirin and Thyroid

[youngsinatra]

SALICYLATE is a powerful metabolic stimulant in animals (Reid, J., personal communication, 1952), in man and in tissue slices.
In hypothyroid patients it is possible to restore the basal metabolic rate to normal levels with dosage of the order of 8 grams of aspirin daily in divided doses.

Source: Comparison of the Metabolic Stimulating Action of Aspirin and Thyroid - Nature

 

[canadianboymike]

I couldn’t read the study because I’m not a member. Is there a way you can copy and post it here. I’m interested in reading it. Just not for $200. Thank you

 

[Thoth]

I couldn’t read the study because I’m not a member. Is there a way you can copy and post it here. I’m interested in reading it. Just not for $200. Thank you

 

[MikeyFitz]

SALICYLATE is a powerful metabolic stimulant in animals (Reid, J., personal communication, 1952), in man and in tissue slices.
In hypothyroid patients it is possible to restore the basal metabolic rate to normal levels with dosage of the order of 8 grams of aspirin daily in divided doses.

Source: Comparison of the Metabolic Stimulating Action of Aspirin and Thyroid - Nature

Interesting study!

On various podcasts and in many studies and posts made on this forum we are seeing huge differences in the amount and frequency of aspirin dosing.

One study had people using 19 grams per day and completely reversing diabetes.

Then we hear on a very recent podcast that Ray Peat only took a couple of tablets a week, and only when he remembered.

I'm wondering how we determine what the proper dosage and frequency should be for us?

We know the myths about aspirin and bleeding have been debunked, but are there other dangers to using too much aspirin and too frequently?

What's the "sweet spot" for us individually and how do we determine it?

 

[cremes]

I wish the article included some kind of time frame on the dose-response curve. Was this effect immediate? Did it require X days/weeks for it to appear?

My guess is that this effect is near immediate and happens within a few hours. I take a single 81mg baby aspirin every day and am on a potent anti-platelet so I won't be experimenting with this one myself.

 

[youngsinatra]

Interesting study!

On various podcasts and in many studies and posts made on this forum we are seeing huge differences in the amount and frequency of aspirin dosing.

One study had people using 19 grams per day and completely reversing diabetes.

Then we hear on a very recent podcast that Ray Peat only took a couple of tablets a week, and only when he remembered.

I'm wondering how we determine what the proper dosage and frequency should be for us?

We know the myths about aspirin and bleeding have been debunked, but are there other dangers to using too much aspirin and too frequently?

What's the "sweet spot" for us individually and how do we determine it?

Yeah in the past, astronomically high doses of aspirin were given to people.

I think vitamin K1 in proper dosage can possibly prevent the bleeding risk.

 

[Highserotonin90]

Make sure you have a well functioning liver...

 

[schultz]

Make sure you have a well functioning liver...

A normal daily dose of aspirin will help with that.

 

[aniciete]

A normal daily dose of aspirin will help with that.

Good luck processing salicylates with a sluggish liver

 

[EvanHinkle]

Good luck processing salicylates with a sluggish liver

Nothing a gram of caffeine for a couple weeks can’t fix, (at least in my experience).

 

[aniciete]

Nothing a gram of caffeine for a couple weeks can’t fix, (at least in my experience).

I did that too and it gave me insomnia

 

[cremes]

I did that too and it gave me insomnia

What worked? Or do you still have a sluggish liver?

 

[aniciete]

What worked? Or do you still have a sluggish liver?

Moving out of my moldy home has basically fixed every problem that I associated with liver issues.

 

[A-Tim]

I couldn’t read the study because I’m not a member. Is there a way you can copy and post it here. I’m interested in reading it. Just not for $200. Thank you

Sci-Hub: breaking academic paywalls since 2011

Sci-Hub website. Get free access to academic journals. Download research papers for free from ScienceDirect, IEEE, Wiley, Springer, Nature and others

sci-hub.se

Your new best friend.

 

[canadianboymike]

Sci-Hub: breaking academic paywalls since 2011

Sci-Hub website. Get free access to academic journals. Download research papers for free from ScienceDirect, IEEE, Wiley, Springer, Nature and others

sci-hub.se

Your new best friend.

Ouuuu I like. Thanks

 

[haidut]

One study had people using 19 grams per day and completely reversing diabetes.

It was around 7g-9g (study used to say a 90mg/kg daily dose, but that as been removed since I last redit), not 19g. Though, the 7g-9g is also not a small dose but it is quite close to the 8g dose that restored normal metabolic rate in the study above.

Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes - PubMed

Recent studies have implicated fatty acid-dependent activation of the serine kinase IKKbeta, which plays a key role in tissue inflammation, in the pathogenesis of insulin resistance. High doses of salicylates have recently been shown to inhibit IKKbeta activity and might therefore ameliorate...

pubmed.ncbi.nlm.nih.gov

 

[NewACC]

Interesting study!

On various podcasts and in many studies and posts made on this forum we are seeing huge differences in the amount and frequency of aspirin dosing.

One study had people using 19 grams per day and completely reversing diabetes.

Then we hear on a very recent podcast that Ray Peat only took a couple of tablets a week, and only when he remembered.

I'm wondering how we determine what the proper dosage and frequency should be for us?

We know the myths about aspirin and bleeding have been debunked, but are there other dangers to using too much aspirin and too frequently?

What's the "sweet spot" for us individually and how do we determine it?

@haidut @Hans aspirin has always definitely been a very powerful pro metabolic supplement and at the doses indicated in the study (8g) I always started to sweat horribly and almost got a fever but felt great. At the same time, I got terrible intestinal side effects and was almost deaf and couldn't hear the upper frequencies in the sound and had terrible tinnitus all the time. So I'm afraid to imagine what happened with crazy 19g aspirin per day in diabetics

 

[youngsinatra]

@haidut @Hans aspirin has always definitely been a very powerful pro metabolic supplement and at the doses indicated in the study (8g) I always started to sweat horribly and almost got a fever but felt great. At the same time, I got terrible intestinal side effects and was almost deaf and couldn't hear the upper frequencies in the sound and had terrible tinnitus all the time. So I'm afraid to imagine what happened with crazy 19g aspirin per day in diabetics

Haidut posted a study where glycine increased the absorption and thus bioavailability of aspirin by 3-fold. So that could cut the needed dose of 8g down to ~ 2.5g.

Glycine Increases Aspirin Absorption

Glycine is known to protect the gastric mucosa against any potential irritation by aspirin and other known irritants like alcohol and phosphoric acid. According to this study, glycine increases aspirin absorption 3-fold and as such people having issues with high doses aspirin can reduce their...

raypeatforum.com

Glycine also helps with gastrointestinal side effects.

Glycine Virtually Eliminates Adverse GI Effects Of Aspirin

I posted a study earlier on co-administration of glycine improving the absorption of aspirin. It looks like it also prevents the negative GI symptoms of aspirin intake in some people. The ratio needed is 2:1 in favor of aspirin, which means that if you are taking 1g of aspirin, you need to take...

raypeatforum.com

Negative effects of aspirin may be due to glycine depletion

Some people have trouble taking aspirin even in small doses. Most often they get symptoms like tinnitus, GI discomfort, nervous system overexcitement, etc. It just happens that glycine (and also taurine) happen to help with all of these symptoms. So, I did some digging and it looks like aspirin...

raypeatforum.com

Regarding hearing issues:

Glycine May Treat Hearing Issues Caused By NSAID (aspirin?)

It is common knowledge that several NASID drugs, including aspirin, cause hearing issues at higher doses. This new research found that the mechanism of action is by competition with chloride ions for activation of the hearing protein called prestin. This suggests a possible method of blocking...

raypeatforum.com

I personally always dissolve 1-2 tablets of aspirin in 200ml of water, put it in the microwave for 1-2 min, then stirr it, let it settle for 30s, then filter it through a coffee-paper-filter. Then you have a clear aspirin solution, which does not cause any GI upset (in my case), up to 1g even. (And I used to get severe side effects by baby aspirin in the past!)

Today I tried adding in 2g of glycine to 300mg of aspirin and I am pretty sure the study of haidut is correct regarding glycine’s effect of raising aspirin absorption. I hit 37.3 C bodytemperature and 85 bpm pulse and was feeling very energetic.

 

[youngsinatra]

Seems like aspirin also affects the liver/bile flow similarly to T3:

„Aspirin stimulated cholesterol secretion to a degree similar to triiodothyronine.“

Oral acetylsalicylic acid induces biliary cholesterol secretion in the rat - PubMed

Several agents can alter biliary cholesterol secretion, critical for cholesterol excretion and gallstone formation. Although salicylate effects on bile formation and gallstones have been studied, biliary lipid secretion has not been measured during oral aspirin treatment. We examined whether...

pubmed.ncbi.nlm.nih.gov

Effect of aspirin on gallbladder motility in patients with gallstone disease - Digestive Diseases and Sciences

Patients with gallstone disease have impaired gallbladder motility. Prostaglandins are thought to be important mediators of gallbladder hypomotility. We assessed the effect of aspirin, a prostaglandin inhibitor on gallbladder resting volume and ejection fraction according to a double-blind study...

link.springer.com

Many (sometimes toxic) things can increase biliary secretion, especially if the substance is „detoxified“ and cleared via the bile. Well, with aspirin, that is not the case.

Biliary elimination of aspirin after oral and intravenous administration in patients. | Semantic Scholar

It is concluded that biliary elimination and subsequent enterohepatic circulation plays no (aspirin) or only a minor role (salicylic acid) in the excretion of aspirin in man. Five patients suffering from various diseases were investigated for biliary elimination of aspirin given i.v. (500 mg, n...

www.semanticscholar.org

 

[NewACC]

Haidut posted a study where glycine increased the absorption and thus bioavailability of aspirin by 3-fold. So that could cut the needed dose of 8g down to ~ 2.5g.

Glycine Increases Aspirin Absorption

Glycine is known to protect the gastric mucosa against any potential irritation by aspirin and other known irritants like alcohol and phosphoric acid. According to this study, glycine increases aspirin absorption 3-fold and as such people having issues with high doses aspirin can reduce their...

raypeatforum.com

Glycine also helps with gastrointestinal side effects.

Glycine Virtually Eliminates Adverse GI Effects Of Aspirin

I posted a study earlier on co-administration of glycine improving the absorption of aspirin. It looks like it also prevents the negative GI symptoms of aspirin intake in some people. The ratio needed is 2:1 in favor of aspirin, which means that if you are taking 1g of aspirin, you need to take...

raypeatforum.com

Negative effects of aspirin may be due to glycine depletion

Some people have trouble taking aspirin even in small doses. Most often they get symptoms like tinnitus, GI discomfort, nervous system overexcitement, etc. It just happens that glycine (and also taurine) happen to help with all of these symptoms. So, I did some digging and it looks like aspirin...

raypeatforum.com

Regarding hearing issues:

Glycine May Treat Hearing Issues Caused By NSAID (aspirin?)

It is common knowledge that several NASID drugs, including aspirin, cause hearing issues at higher doses. This new research found that the mechanism of action is by competition with chloride ions for activation of the hearing protein called prestin. This suggests a possible method of blocking...

raypeatforum.com

I personally always dissolve 1-2 tablets of aspirin in 200ml of water, put it in the microwave for 1-2 min, then stirr it, let it settle for 30s, then filter it through a coffee-paper-filter. Then you have a clear aspirin solution, which does not cause any GI upset (in my case), up to 1g even. (And I used to get severe side effects by baby aspirin in the past!)

Today I tried adding in 2g of glycine to 300mg of aspirin and I am pretty sure the study of haidut is correct regarding glycine’s effect of raising aspirin absorption. I hit 37.3 C bodytemperature and 85 bpm pulse and was feeling very energetic.

very interesting, maybe I should really add gelatin, you are right, thanks!