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3.3. Effect of Chlorogenic Acid on Serum LPS Levels and the Expression of Related Inflammatory Cytokines
Serum inflammatory cytokine levels for each animal group are shown in Figure 4. Compared with the NC group, the levels of the proinflammatory factors, TNF-α, MCP-1, IL-6, and LPS, increased by 69.63%, 94.99%, 59.39%, and 207.33%, respectively, in the HFD group. The levels of TNF-α, MCP-1, IL-6, and LPS in the HFD+SPR and HFD+CGA groups were significantly lower than those observed in the HFD group (); in the HFD+SPR group, the levels of these factors decreased by 12.37%, 225.95%, 53.52%, and 302.93%, respectively, and in the HFD+CGA group, the levels were decreased by 135.23%, 308.16%, 66.78%, and 265.34%, respectively.
These results revealed that CGA [Clorogenic acid] can relieve inflammation caused by an HFD, and its effect was superior to that demonstrated by dietary correction.