Aspirin bad??? Unlikely!!!

[TucsonJJ]

View: https://www.reddit.com/r/raypeat/comments/192oscy/chris_masterjohn_aspirin_is_a_mitochondrial_toxin/


I just stumbled on to this rather incredible post on Reddit...

I'd like to see you guys tear this apart, as I expect...
Does he have any credibility at all?

I bet Dinkov would beg to differ... !!

 

[Jamsey]

Besides the ridiculous study design of testing on isolated cardiac mitochondria, this is a direct quote from the study itself

“It has been estimated that total plasma salicylate concentrations are 0.5, 1.5 to 2.5, and 3.0 to 10 mM in humans taking analgesic doses, taking therapeutic doses for rheumatoid arthritis, or exposed to acute poisoning, respectively.22 Under these 3 scenarios, based on binding to albumin and other plasma proteins, the concentration of free circulating salicylate is estimated to be 0.005, 0.15 to 0.6, and 1.0 to 5.0 mM. Salicylic acid and acetylsalicylate were found to exert significant and immediate effects on mitochondrial function at low millimolar concentrations (Fig. 2). These alterations would therefore be expected to occur in vivo during acute poisoning”

To tweet out ‘aspirin is a mitochondrial toxin’ and link this study is just reaction seeking and diminishes my view of him.

 

[Jamsey]

Here is a real study on mitochondrial respiration and aspirin. The study he posted claimed that aspirin inhibited state 3 respiration in mitochondria. This study shows directly the opposite when aspirin is used in real conditions instead of bathing isolated mitochondria in aspirin solution.

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“The respiration and oxidative phosphorylation by liver mitochondria from control and aspirin-treated rats with different substrates are shown in Table 1. There were significant increases in state 3 respiration rate by mitochondria from aspirin-treated rats as compared to controls with pyruvate (50 per cent), a-ketoglutarate (38 per cent) and succinate (20 per cent) as substrate. The controlled respiration (in state 4), where ADP is limited, was also significantly increased (P < 0.05) with all three substrates tested by mitochondria from aspirin-treated rats.”

 

[TucsonJJ]

Here is a real study on mitochondrial respiration and aspirin. The study he posted claimed that aspirin inhibited state 3 respiration in mitochondria. This study shows directly the opposite when aspirin is used in real conditions instead of bathing isolated mitochondria in aspirin solution.

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“The respiration and oxidative phosphorylation by liver mitochondria from control and aspirin-treated rats with different substrates are shown in Table 1. There were significant increases in state 3 respiration rate by mitochondria from aspirin-treated rats as compared to controls with pyruvate (50 per cent), a-ketoglutarate (38 per cent) and succinate (20 per cent) as substrate. The controlled respiration (in state 4), where ADP is limited, was also significantly increased (P < 0.05) with all three substrates tested by mitochondria from aspirin-treated rats.”

Is this Masterjohn a known clown?

Also... I would think methylene blue would be great for mitochondria too, as Dinkov says... I wonder if it is OK to take with chlorpheniramine, as it supposedly effects serotonin too... ?? OR, is Benadryl a better option?