7,8-dihydroxyflavone (bdnf mimic) - Regenerates thymus, restores bone marrow activity, boosts hematopoietic stem cells, enhances bone strength

[cs3000]

As well as increasing neurogenesis (with antidepressent effect linked to increasing neuron number or myelination in the hippocampus) ,
BDNF has effects outside of the brain.
as BDNF /TrkB expression is also found in decent amounts elsewhere in the body.
e.g spleen, thymus bone marrow

7,8-dihydroxyflavone aka Tropoflavin

Brain-derived neurotrophic factor promotes immune reconstitution following radiation injury via activation of bone marrow mesenchymal stem cells

we observed that systemic administration of either BDNF or TrkB agonist 7,8-DHF accelerated the recovery of bone marrow function and increased hematopoietic stem cell content -> An immature cell that can develop into all types of blood cells, including white blood cells, red blood cells, and platelets. Hematopoietic stem cells are found in the peripheral blood and the bone marrow. Also called blood stem cell.. aka +RBC +WBC , lymphocytes​

Since BDNF and its receptor TrkB are expressed in the thymus, we next evaluated whether exogenous BDNF administration following radiation injury regulated both early (day 10) and late (day 120) recovery of the thymus. At day 10 following radiation, there is a decrease in total thymus mass compared to day 0 non-irradiated controls (dotted line) in both the saline and BDNF treated groups (Fig 5A). However, at 120 days post-injury, the thymus is significantly enlarged in the BDNF treated group compared to irradiated controls Treatment with BDNF significantly improves recovery of DP thymocytes ​

https://elifesciences.org/articles/64872#s3
(as it shows here, bone density doesn't necessarily correlate with nice bone strength increase)

low dose worked best for actual bone strength tests, boosted more than controls

the promotion effect of BDNF on osteoblast migration and fracture healing is also via TrkB.

5mg/kg rat dose (might be a bit high, [Going too far with BDNF can reverse into detrimental effect from glutamate increase, maybe 50mg of 7,8 DHF would be excessive]. (doubling the dose to 10mg/kg rat dose showed weaker effect)
10mg-25mg human dose orally should work similarly, seeing as only low doses were used in the mice study above with effect.

https://pubmed.ncbi.nlm.nih.gov/28882412/

mice were treated with 7,8-DHF from P3 to adolescence (P45-50) and were tested with the Morris Water Maze. Treated Ts65Dn mice exhibited improvement of learning and memory, indicating that the recovery of the hippocampal anatomy translated into a functional rescue.
Our study in a mouse model of DS provides novel evidence that treatment with 7,8-DHF during the early postnatal period restores the major trisomy-linked neurodevelopmental defects, suggesting that therapy with 7,8-DHF may represent a possible breakthrough for Down syndrome.

 

[Highserotonin90]

thanks

 

[Ras]

Nootropics Depot sells this in pills and powder.

 

[Fllora]

As well as increasing neurogenesis (with antidepressent effect linked to increasing neuron number or myelination in the hippocampus) ,
BDNF has effects outside of the brain.
as BDNF /TrkB expression is also found in decent amounts elsewhere in the body.
e.g spleen, thymus bone marrow

7,8-dihydroxyflavone aka Tropoflavin

Brain-derived neurotrophic factor promotes immune reconstitution following radiation injury via activation of bone marrow mesenchymal stem cells



https://elifesciences.org/articles/64872#s3
(as it shows here, bone density doesn't necessarily correlate with nice bone strength increase)

low dose worked best for actual bone strength tests, boosted more than controls

5mg/kg rat dose (might be a bit high, [Going too far with BDNF can reverse into detrimental effect from glutamate increase, maybe 50mg of 7,8 DHF would be excessive]. (doubling the dose to 10mg/kg rat dose showed weaker effect)
10mg-25mg human dose orally should work similarly, seeing as only low doses were used in the mice study above with effect.

View attachment 50400

https://pubmed.ncbi.nlm.nih.gov/28882412/

Thanks for this post. I have a friend who was just diagnosed with pre-fibrotic myelofibrosis: (Wiki) "...a rare blood cancer, classified by the World Health Organization as a distinct type of myeloproliferative neoplasm in 2016.[1] The disease is progressive to overt primary myelofibrosis, though the rate of progression is variable and not all patients progress. Symptoms and presentation can mimic essential thrombocythemia, with the main differentiator for pre-PMF being the presence of fibrosis in the bone marrow."
Was plumbing the RP forum and ended up here. Looking at research now; if anyone on this forum has dealt with this, please post.

 

[Dave Clark]

Interesting. Does anyone know if there would be any contraindication with selegiline?

 

[richofden]

GUNA Biotherapeutics GUNA-BDNF

GUNA-BDNF by Guna Biotherapeutics is a liquid homeopathic supplement that may promote healthy nerve function. Active Ingredients: Brain-Derived Neurotrophic Factor 4C Inactive Ingredients: Ethyl alcohol 30% Directions: Take 15 minutes before meals. Adults and children 12 years and older: 20...

supplementfirst.com