niacinamide

  1. haidut

    Niacinamide Can Treat Alcoholic Liver Disease

    As many forum users have probably heard on the news, alcohol abuse is now a leading cause of death in young people under 35. It is projected to soon surpass drug overdose as a cause of death in this demographic. Millennials are dying of alcohol-related liver disease at increasing rates The...
    • haidut
    • Thread
    • alcohol alcoholism cirrhosis liver liver disease liver steatosis nad nad/nadh niacinamide nicotinamide riboside nr prevent redox
    • Replies: 3
    • Forum: Scientific Studies
  2. Koveras

    Tuberculosis Depletes NAD+ (and Niacinamide May Be Able To Treat It)

    As I was getting this post ready, I saw that haidut beat me to the punch by 3 years or so - but maybe the 2018 article that spurred this will answer @Giraffe 's question ("what's the mechanism?") in that thread Niacinamide May Be Able To Treat Both HIV And Tuberculosis Pulling from instagram...
  3. haidut

    Niacinamide May Treat (acute) Kidney Failure (AKI) - Human Study

    It seems modern medicine is slowly starting to recognize the role of energy in organ health, and more specifically the role of NAD/NADH ratio in variety of diseases long thought to be mostly mechanism in origin. A few months ago, I posted a study on raising NAD levels with nicotinamide riboside...
    • haidut
    • Thread
    • acute kidney injury aki creatinine kidney disease kidney failure nad nad+ nad/nadh niacinamide redox status
    • Replies: 6
    • Forum: Scientific Studies
  4. haidut

    Fatty Acid Oxidation (FAO) Makes Cancer Therapy-resistant, Niacinamide May Help

    Yet another study that shows FAO playing a crucial role in cancer progression. As many forum users know, anti-angiogenic therapies are one of the cornerstones of current cancer treatments. This therapy typically uses the so-called VEGF inhibitors to block the formation of new blood vessels in...
    • haidut
    • Thread
    • angiogenesis cancer cpt1 fatty acid oxidation hypoxia inhibitor lipolysis metastasis mildronate niacinamide progression tumor vegf
    • Replies: 0
    • Forum: Scientific Studies
  5. haidut

    Niacinamide May Be A Viable Treatment For Parkinson Disease (PD)

    It looks like the pharma industry is experiencing a resurgence in the search for metabolic therapies with patented chemicals. There must have been at least 50 different studies in 2017 alone with the NAD precursor nicotinamide riboside (NR) for conditions ranging from cancer, to glaucoma, to...
    • haidut
    • Thread
    • disease energy metabolism mitochondria nad nad/nadh nam niacinamide nicotinamide riboside nr parkinson
    • Replies: 8
    • Forum: Scientific Studies
  6. haidut

    Niacinamide Lowers BP, May Reverse CVD And Reduce Heart Attack Risk By 25%

    This is a human study, so the findings are that much more relevant even though they probably do not come as a surprise to users of this forum. The duration of the study was just 6 weeks and the dose was 500mg nicotinamide riboside (NR) twice a day (for a total of 1,000mg). There were no side...
    • haidut
    • Thread
    • arterial stiffness blood pressure cvd heart attack hypertension niacinamide nicotinamide riboside nr prevent reverse vitamin b3
    • Replies: 14
    • Forum: Scientific Studies
  7. haidut

    New Human Trial With An NAD Precursor

    I just wanted to post this here, as it seems interest in raising NAD is high among pharma companies. While nicotinamide riboside is the most popular precursor used in the Western world, nicotinamide mononucleotide (NMN) is another one that has been used clinically. This clinical trial below...
    • haidut
    • Thread
    • aging human low dose mitochondria nad niacinamide nicotinamide mononucleotide steroidogenesis trial
    • Replies: 15
    • Forum: Scientific Studies
  8. haidut

    Niacinamide May Treat Brain Cancer (glioblastoma)

    Neuroblastoma is one of the most common brain cancers and one of the most lethal ones of all cancers. Senator John McCain is probably the most famous recent victims of this cancer, and others famous cases include Senator Ted Kennedy and one of Joe Biden's son. The latter two died from the cancer...
    • haidut
    • Thread
    • block brain cancer glioblastoma inhibit neuroblastoma neuroglioblastoma niacinamide sirt6 sirtuins tumor vitamin b3
    • Replies: 8
    • Forum: Scientific Studies
  9. haidut

    Colon Aging / Cancer? Due To Low NAD / High Serotonin; Niacinamide Reverses Both

    Peat has said many times that the impaired bowel regularity that occurs in aging, hypothyroidism and various pathologies is due to high NO and serotonin. He also said that while serotonin inhibits motility in the colon it increases it in the small intestine. Most doctors do not agree with that...
    • haidut
    • Thread
    • 5-ht4 aging colon colon cancer niacinamide nmn serotonin serotonin uptake sert tph tph2
    • Replies: 33
    • Forum: Scientific Studies
  10. haidut

    Niacinamide Retards/Reverses Aging And Physiological Decline

    Yet another study on the beneficial effects of raising NAD levels, and unlike other recent studies this one is not sponsored by ChromaDex. This study used nicotinamide mononucleotide (NMN), and human studies have shown that niacinamide is equally effective as NMN in raising NAD levels. Also, as...
    • haidut
    • Thread
    • aging nad nad+ niacinamide nicotinamide mononucleotide nmn reversal vitamin b3
    • Replies: 32
    • Forum: Scientific Studies
  11. Travis

    On Pellagra

    Pellagra is fairly well understood, but there is still some persistent mythology surrounding the etiology. Everyone knows that niacin is the characteristic deficiency, but few are aware of the central importance that leucine plays in this. The somewhat low tryptophan and niacin content of corn...
    • Travis
    • Thread
    • cholesterol leucine niacin niacinamide pellagra zinc
    • Replies: 17
    • Forum: Skin
  12. B

    Niacinamide Enhances Creatine Neuroprotectiveness Against NMDA Agonist Toxicity

    Creatine can, therefore, produce significant neuroprotective effects against NMDA mediated excitotoxic lesions in vivo and the combination of nicotinamide with creatine exerts additive neuroprotective effects Neuroprotective effects of creatine administration against NMDA and malonate toxicity...
  13. haidut

    Niacinamide And Doxycycline May Treat Alzheimer Disease (AD)

    This study is yet another one that shows benefit of raising NAD levels for treating neurodegenerative conditions like AD. There were a few older studies around 2003, which were also done on mice and as a result of those studies a human clinical trial with 3g niacinamide daily (a dose that...
    • haidut
    • Thread
    • alzheimer's cure doxycycline metabolic mitochondria mitochondrial dysfunction nad niacinamide parkinson reverse treat
    • Replies: 7
    • Forum: Scientific Studies
  14. haidut

    Niacinamide May Treat ALS (and Stroke)

    I posted a few studies in the past demonstrating that ALS is a mitochondrial/metabolic disease and as such can be treated with pro-metabolic therapies like thyroid or copper (currently in clinical trials). This new study shows that raising NAD levels with the NAD precursor nicotinamide...
  15. Giraffe

    Niacinamide In The Treatment Of Osteoarthritis

    The effect of niacinamide on osteoarthritis: A pilot study In the 1940's and 50's William Kaufman treated several hundred patients with both osteo and rheumatoid arthritis with large doses of niacinamide. The researchers here are following Kaufman's approach. They conducted a three month...
  16. haidut

    Human Study Confirms Alzheimer As A Metabolic Condition (brain Diabetes)

    Over the last 3 years I posted quite a few studies on Alzheimer disease (AD) and have discussed it at length in the Danny Roddy podcasts. Among the most successful interventions are niacinamide and methylene blue (MB) both of which are in human clinical trials, thyroid and aspirin. Alzheimer...
    • haidut
    • Thread
    • alzheimer's aspirin brain cytochrome c dementia estrogen fatty acid oxidation glucose metabolic metabolism methylene blue niacinamide pufa starvation stress sugar thyroid
    • Replies: 22
    • Forum: Scientific Studies
  17. haidut

    High-dose Vitamin C Or Niacinamide May Treat Advanced Colon Cancer

    I posted a few studies recently on vitamin C and niacinamide as potential cancer treatments. Linus Pauling May Have Been Vindicated - Vitamin C May Treat Cancer Inhibiting Lipolysis May Treat / Cure Cancer This new study corroborates these initial findings. Unfortunately, the study is worded in...
    • haidut
    • Thread
    • advanced ascorbic acid cancer colon colorectal cure high-dose niacinamide treat vitamin b3 vitamin c
    • Replies: 13
    • Forum: Scientific Studies
  18. haidut

    More Than One Third Of Men And Almost Half Of Women Are Energy Deficient

    I wanted to note from the start that this is NOT about calories, this is about ENERGY deficiency as a result of bad metabolism. So, while not the same as hypothyroidism, this study shows just how sick the general population is (if we assume that energetic deficiency is behind all diseases). Now...
    • haidut
    • Thread
    • deficiency deficient diet energy men niacin niacinamide thiamine vitamin b1 women
    • Replies: 72
    • Forum: Scientific Studies
  19. haidut

    Niacinamide May Prevent Melanoma

    About 2 years ago an Australian study hit frontpage news. It found that ingesting 1g niacinamide daily significantly reduced the risk of non-melanoma skin cancers. Vitamin B3 Prevents And Reverses Skin Cancer Now, a new study and a review found that the same dose of niacinamide may work for...
    • haidut
    • Thread
    • high-risk melanoma niacinamide prevent skin cancer treat vitamin b3
    • Replies: 4
    • Forum: Scientific Studies
  20. haidut

    Niacinamide May Fully Prevent Miscarriages And/or Birth Defects

    I posted recently about the drastic reduction (or even reversal) of pre-eclampsia in pregnant women who took a small dose of aspirin. Aspirin Can Treat Pre-eclampsia Up until that study on aspirin came out, pre-eclampsia was considered untreatable and when a woman develops it usually the only...
    • haidut
    • Thread
    • birth defects fetal malformations miscarriage nad niacinamide prevent stillbirth
    • Replies: 1
    • Forum: Scientific Studies
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