niacinamide

  1. P

    Any Recommendations For A Legit Niacinamide Supplement? Is The NOW! Foods Niacinamide Fake?

    Hello everybody, Has anyone here had consistent powerful results (either good or bad) or experience with a reliable niacinamide brand? What brands are the real deal? The only brand that I knew of was Solaray -thanks to @Dan Wich 's website, and I used it very successfully in doses ranging from...
    • PakPik
    • Thread
    • niacinamide supplemental supplier vitamin b3
    • Replies: 27
    • Forum: B3/Niacinamide
  2. P

    NAD⁺ Repletion Improves Mitochondrial And Stem Cell Function And Enhances Life Span In Mice

    NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice. - PubMed - NCBI Adult stem cells (SCs) are essential for tissue maintenance and regeneration yet are susceptible to senescence during aging. We demonstrate the importance of the amount of the oxidized...
  3. haidut

    HDAC Inhibitors Affect Every Function Of The Cell And May Extend Lifespan

    The use of HDAC inhibitors such as valproic acid or various butyrate salts for cancer treatment has been studied experimentally for decades. Until now, it was assumed that the process of histone acetylation and deacetylation affected mostly the processes associated with cell division and...
    • haidut
    • Thread
    • acetylation aging cell function hdac hdac inhibitor histone lifespan niacinamide sirtuins survival vital
    • Replies: 12
    • Forum: Scientific Studies
  4. haidut

    Positive Impact Of Vitamin B3 On CVD Is Not Due To Lowering Cholesterol

    Comparisons with treatment with niacin to raise HDL and lower LDL has been considered the gold-standard for all new statin drugs. However, it has been shown that both niacin and niacinamide have the same protective effects on cardiovascular disease (CVD) despite the fact that niacinamide has...
    • haidut
    • Thread
    • antiinflammatory arthritis atherosclerosis cvd gpr109a heart disease multiple sclerosis niacin niacinamide study vitamin b1 vitamin b3
    • Replies: 4
    • Forum: Scientific Studies
  5. haidut

    Achilles Heel Of Cancer Found - Its Addiction To Fat

    The public propaganda message has always been that cancer cells are addicted to glucose. As a result of that belief, one of the so-called "new wave" therapies in the treatment of cancer is to "starve" the cancer cells of glucose and hope that they die on their own. This usually has disastrous...
    • haidut
    • Thread
    • addiction aspirin c75 cancer doxycycline emodin endothelial lipase fat foxa heel inhibitor lipg niacinamide orlistat study
    • Replies: 28
    • Forum: Scientific Studies
  6. haidut

    Rheumatoid Arthritis Is A Metabolic Disease; Vitamin K And Niacinamide May Treat It

    Ray has written so many articles on how "autoimmune conditions" like MS, rheumatoid arthritis (RA), lupus, psoriasis, etc are all metabolic diseases mostly driven by estrogen. After decades of denial by mainstream medicine, a study was just published by a team at Stanford that shows RA to be...
    • haidut
    • Thread
    • arthritis disease menaquinone metabolic niacinamide reactive oxygen species reduction reversible rheumatoid stress study vitamin b3
    • Replies: 59
    • Forum: Scientific Studies
  7. P

    Mitochondrial Nutrients Stimulate Performance And Mitochondrial Biogenesis In Exhaustively Exercised

    Mitochondrial nutrients stimulate performance and mitochondrial biogenesis in exhaustively exercised rats. - PubMed - NCBI Abstract The aim of this study was to investigate the effects of a combination of nutrients on physical performance, oxidative stress and mitochondrial biogenesis in...
    • paymanz
    • Thread
    • coq10 creatine mitochondria mitochondriogenesis niacinamide study taurine vitamin b2 vitamin b6 vitamin b7
    • Replies: 1
    • Forum: Articles & Scientific Studies
  8. haidut

    Niacinamide May Treat Hepatitis B

    As the forum members know well already, niacinamide is not only a potent anti-viral but also protects from auto-immunity. The hepatitis conditions are unique in the sense that they considered both viral infections and auto-immune conditions, that are "incurable" unless you buy $200K worth of...
    • haidut
    • Thread
    • damage fibrosis hepatitis liver niacinamide study virus
    • Replies: 1
    • Forum: Scientific Studies
  9. haidut

    Niacinamide Is Androgenic And Increases Dht Effects/signaling

    I just posted a study showing that inhibition of SIRT1 is anti-estrogenic, and SIRT1 inhibitors like niacinamide have similar effects to the estrogen receptor antagonist fulvestrant. Niacinamide Is Anti-estrogenic | Ray Peat Forum This study shows that, again through inhibition of SIRT1...
    • haidut
    • Thread
    • androgenic androgens dht hdac inhibitor niacinamide receptor sirt1 sirtuins study
    • Replies: 48
    • Forum: Scientific Studies
  10. haidut

    Niacinamide Is Anti-estrogenic

    Yet another strong point for niacinamide. I am beginning to wonder if there is any condition or biomarker of disease that niacinamide cannot affect. Peat has written many times about the sirtuin genes and their promoter resveratrol. While there is already quite a bit of evidence that SIRT1...
    • haidut
    • Thread
    • antagonist estrogen fulvestrant hdac inhibition niacinamide sirt1 sirtuins study suppression
    • Replies: 36
    • Forum: Scientific Studies
  11. haidut

    The Anti-cortisol Effects Of Niacinamide

    This is yet another confirmation of my suspicion that sedative substances lower cortisol levels. Niacinamide is officially recognized as a GABA-A agonist, but apparently this is not the major reason behind its effect on cortisol. The enzyme that de-activates cortisol - 11b-HSD2 - is apparently...
    • haidut
    • Thread
    • 11β-hsd1 11β-hsd2 cortisol diabetes hypertension niacinamide obesity study
    • Replies: 43
    • Forum: Scientific Studies
  12. haidut

    Niacinamide Fully Prevents Breast Cancer Metastasis

    In yet another winning day (as Trump likes to say) for niacinamide, this study shows that the metastatic process of breast cancer is controlled by the NAD/NADH ratio, and NAD precursors like niacinamide can be effective chemotherapeutic agents. The human equivalent dose was 3g - 3.5g daily for a...
    • haidut
    • Thread
    • breast cancer metastasis nad nad+ nadh niacinamide prevention
    • Replies: 3
    • Forum: Scientific Studies
  13. haidut

    Niacinamide Causes Dramatic Increase In Nad And Fall In Lactate

    The good things about this study is that it is human and as such the doses are directly relevant. Given that the patient had MELAS, the niacinamide dose used was on the high end but still quite reasonable and comparable to the human trials of niacinamide in Alzheimer disease and stroke. The...
  14. I

    Niacinamide Parkinson's Connection?

    I came a cross a thread on longecity called "niacin neurotoxicty" and its got me a little worried. this is the study: http://qjmed.oxfordjournals.org/content/98/3/215.full and this is the thread: http://www.longecity.org/forum/topic/20190-niacin-neurotoxicity/ . Niacinamide is really doing...
  15. E

    Niacinamide Inhibits Sirtuins. Reason To Not Take Niacinamide?

    Nicotinamide (aka niacinamide) may be a potent promoter of aging. Please see #5 in the following article which also mentions other issues with niacinamide...
  16. milk_lover

    Is It Good To Supplement Niacinamide After A Fatty Lunch?

    It's been two days now after eating lunch, I take 100mg niacinamide. I get so sleepy and tired no matter how many cups of coffee I drink. In fact, I get even more sleepy after drinking coffee. What is going on here? Is it not good to take niacinamide after a fatty meal? I tested something out...
  17. haidut

    A Cousin Of Niacinamide Cures Diabetes Type I

    There have been several trials with niacinamide on type I diabetes and it seems effective in about 40% of the cases, especially when the beta cells of the pancreas are still viable. Probably as a result of these successful studies, big pharma has been looking to capitalize on these results for...
  18. P

    Cell Life Versus Cell Longevity: The Mysteries Surrounding The Nad+ Precursor Nicotinamide

    www.ncbi.nlm.nih.gov/pmc/articles/PMC2248696/ Abstract Nicotinamide, the amide form of niacin (vitamin B3), is the precursor for the coenzyme β-nicotinamide adenine dinucleotide (NAD+) and plays a significant role during the enhancement of cell survival as well as cell longevity. Yet, these...
  19. haidut

    Low Dose Niacinamide Prevents NAFLD / Cirrhosis

    The study used an animal model that is genetically engineered to develop liver fibrosis (cirrhosis) . The human equivalent dose of niacinamide was only 3mg/kg and study duration was 6 weeks. Niacinamide not only fully prevented liver fibrosis but also lowered all markers of liver damage to the...
  20. haidut

    Niacinamide Is A Potent Antifungal Effective Against Candida

    I posted some studies some time ago showing that aspirin and methylene blue are able to eradicate Candida infections. This study adds niacinamide to the tools we have against pathogenic fungi, and it seems niacinamide is especially effective against Candida. The human equivalent dose was 35mg/kg...
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