Tuberculosis Depletes NAD+ (and Niacinamide May Be Able To Treat It)

Discussion in 'Scientific Studies' started by Koveras, Sep 2, 2018.

  1. Koveras

    Koveras Member

    Dec 17, 2015
    As I was getting this post ready, I saw that haidut beat me to the punch by 3 years or so - but maybe the 2018 article that spurred this will answer @Giraffe 's question ("what's the mechanism?") in that thread

    Pulling from instagram here

    "These implications may also apply to other bacterial and fungal pathogens that utilize NAD+ glycohydrolases, such as S. pyogenes (Chandrasekaran and Caparon, 2015) and the over 300 microorganisms encoding TNT homologs (Danilchanka et al., 2014)" (Pajuelo, D, 2018)

    Chorine, V. (1945). Action of nicotinamide on bacilli of the type Mycobacterium. Compte Rendu de l'Academie des Sciences, 220, 150-151

    Murray, M. F. (2003). Nicotinamide: an oral antimicrobial agent with activity against both Mycobacterium tuberculosis and human immunodeficiency virus. Clin Infect Dis, 36(4), 453-460. doi:10.1086/367544

    Pajuelo, D., Gonzalez-Juarbe, N., Tak, U., Sun, J., Orihuela, C. J., & Niederweis, M. (2018). NAD(+) Depletion Triggers Macrophage Necroptosis, a Cell Death Pathway Exploited by Mycobacterium tuberculosis. Cell Rep, 24(2), 429-440. doi:10.1016/j.celrep.2018.06.042

    Seiner, D. R., Hegde, S. S., & Blanchard, J. S. (2010). Kinetics and inhibition of nicotinamidase from Mycobacterium tuberculosis. Biochemistry, 49(44), 9613-9619. doi:10.1021/bi1011157

    Zhang, Y., Shi, W., Zhang, W., & Mitchison, D. (2013). Mechanisms of Pyrazinamide Action and Resistance. Microbiol Spectr, 2(4), 1-12. doi:10.1128/microbiolspec.MGM2-0023-2013

    Wikipedia contributors. (2018, August 23). Tuberculosis. In Wikipedia, The Free Encyclopedia. Retrieved 19:48, September 2, 2018, from Tuberculosis - Wikipedia
  2. fradon

    fradon Member

    Sep 23, 2017
    the body makes NAD from tryptophan so do we increases tryptophan?