Niacinamide May Be Able To Treat Both HIV And Tuberculosis

Discussion in 'Scientific Studies' started by haidut, Sep 11, 2015.

  1. haidut

    haidut Member

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    Apparently, many human trials in the period 1945 - 1960 found it effective for tuberculosis. More recent trials (1990s and on) found it potentially effective for HIV.
    Effective human dose was 3g - 6g a day, with higher doses more effective for HIV.

    http://cid.oxfordjournals.org/content/36/4/453.long
     
  2. Giraffe

    Giraffe Member

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    Shared features of tuberculosis and HIV (from article above)

    - elevation of blood niacin levels
    - plasma tryptophan depletion
    - intracellular nicotinamide adeneine dinucelotide depletion

    From an article about niacin equivalents

    "For three diabetic subjects the average value was 1 mg of niacin from 42.5 mg of tryptophan. In a reinvestigation of this problem involving 19 young men, the value obtained was 1 mg of niacin from 72 mg of tryptophan."

    Suspect a connection?
     
  3. Giraffe

    Giraffe Member

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    It looks like more tryptophan is converted to niacinamide when the body's needs for niacinamide are higher in disease.

    Any ideas as to the mechanism?
     
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