schultz
Member
- Joined
- Jul 29, 2014
- Messages
- 2,653
You can go on pubmed and read old case reports of overdoses. Reading some papers from the late 1800's/early 1900's is pretty entertaining.
This one from 1936 describes some pretty crazy overdoses like a lady who took 100 325mg tablets. She didn't die though.
The same article notes 4 cases of death. 1 man, aged 72, took 150 aspirin tablets. One of his symptoms was profuse sweating, which would be incredible uncoupling probably just like DNP (which can also kill you).
One of the severe symptoms that occurs is dehydration from massive perspiration.
Usually 400-500 grains will be fatal (80 to 100 325mg tablets). Here is a case where someone took 1000 grains and survived. She also drank a half bottle of whiskey lol. Of course it was Britain in 1942 and the paper describes her as being depressed from the war.
If you read a paper like this one ( Use of salicylates in rheumatic fever; mixture of aspirin and vitamin K unwarranted - PubMed ) you sort of get the picture of how much aspirin was deemed acceptable back then.
"It is my belief that the present evidence shows that while salicylates do cause a slight prolongation of the prothrombin time, this is not clinically significant in doses up to 150 grains (10Gm.) daily and hence the routine addition of vitamin K to aspirin is unwarranted."
Of course now we know that aspirin actually depletes vitamin K, and vitamin K has more function than just clotting. But I don't think anyone on the forum takes 10 grams daily, which was not unheard of 100 years ago.
This one from 1936 describes some pretty crazy overdoses like a lady who took 100 325mg tablets. She didn't die though.
The same article notes 4 cases of death. 1 man, aged 72, took 150 aspirin tablets. One of his symptoms was profuse sweating, which would be incredible uncoupling probably just like DNP (which can also kill you).
One of the severe symptoms that occurs is dehydration from massive perspiration.
Usually 400-500 grains will be fatal (80 to 100 325mg tablets). Here is a case where someone took 1000 grains and survived. She also drank a half bottle of whiskey lol. Of course it was Britain in 1942 and the paper describes her as being depressed from the war.
If you read a paper like this one ( Use of salicylates in rheumatic fever; mixture of aspirin and vitamin K unwarranted - PubMed ) you sort of get the picture of how much aspirin was deemed acceptable back then.
"It is my belief that the present evidence shows that while salicylates do cause a slight prolongation of the prothrombin time, this is not clinically significant in doses up to 150 grains (10Gm.) daily and hence the routine addition of vitamin K to aspirin is unwarranted."
Of course now we know that aspirin actually depletes vitamin K, and vitamin K has more function than just clotting. But I don't think anyone on the forum takes 10 grams daily, which was not unheard of 100 years ago.