TeslaFan
Member
- Joined
- Jul 25, 2013
- Messages
- 346
I was reading on some serotonin related research, showing decreased serotonin metabolites in CSF of those depressed patients that attempted suicide (*), as well as often increased density of serotonin receptors in those cases, particularly of 2A (**) and 2C types (***).
Pairing these studies with Ray's writings on serotonin, lead me to suspect the following (which others may have already suggested):
Remember how calcium has a good role when it's in the bones and teeth and how it has a negative role when it gets "spilled" into surrounding tissue -- calcifying the tissue and arteries, and when it enters the cell?
I suspect that serotonin may have somewhat neuro-protective role when it is inside the brain / CNS, and a pro-inflammatory, anti-metabolic role when it gets "spilled" in the blood, as when released from the platelets.
This would go along the studies showing that people who committed suicide have low levels of serotonin in the CFS, and also increased density of serotonin receptors in the brain. Brain will build more protein receptors when activating ligand (in this case, serotonin) is low -- in an attempt to compensate for the lack of signaling.
Consequently, it would make sense that when serotonin is saturated in the brain, the protein receptors would be lowered in numbers / desensitized due to overactive signaling.
So, I suspect that serotonin is context specific in a sense that whether its role is positive or negative depends on the site of action.
Something on the lines of "energy and structure are interdependent, at every level."
Any thoughts?
* http://archpsyc.jamanetwork.com/article ... eid=491608
** http://www.nature.com/npp/journal/v24/n ... 5631a.html
*** http://www.sciencedirect.com/science/ar ... 2896000927
Pairing these studies with Ray's writings on serotonin, lead me to suspect the following (which others may have already suggested):
Remember how calcium has a good role when it's in the bones and teeth and how it has a negative role when it gets "spilled" into surrounding tissue -- calcifying the tissue and arteries, and when it enters the cell?
I suspect that serotonin may have somewhat neuro-protective role when it is inside the brain / CNS, and a pro-inflammatory, anti-metabolic role when it gets "spilled" in the blood, as when released from the platelets.
This would go along the studies showing that people who committed suicide have low levels of serotonin in the CFS, and also increased density of serotonin receptors in the brain. Brain will build more protein receptors when activating ligand (in this case, serotonin) is low -- in an attempt to compensate for the lack of signaling.
Consequently, it would make sense that when serotonin is saturated in the brain, the protein receptors would be lowered in numbers / desensitized due to overactive signaling.
So, I suspect that serotonin is context specific in a sense that whether its role is positive or negative depends on the site of action.
Something on the lines of "energy and structure are interdependent, at every level."
Any thoughts?
* http://archpsyc.jamanetwork.com/article ... eid=491608
** http://www.nature.com/npp/journal/v24/n ... 5631a.html
*** http://www.sciencedirect.com/science/ar ... 2896000927