Inhibition Of Peripheral Serotonin Production Protects From Diet-induced Obesity And Related Complic

Waremu

Member
Joined
Feb 9, 2014
Messages
532
Don't known if someone has already mentioned this recent news from this particular study here already or not, but definitely another point for Dr. Ray Peat.

"Obesity is a major risk factor for chronic disease. A new study in mice reveals that lowering levels of the signaling molecule serotonin outside of the brain reduces obesity and its complications by increasing brown adipose tissue (BAT) energy expenditure."

"Tryptophan (Trp) is converted into serotonin (5-HT) within the brain by the enzyme tryptophan hydroxylase (TPH)2, where it both increases sympathetic nervous system signaling to brown adipose tissue (BAT) and suppresses appetite. In the gastrointestinal tract (GIT), Trp is converted to serotonin by the enzyme Tph1. Crane et al.6 find that reducing circulating serotonin by inhibition of Tph1 or deletion of the Tph1 gene increases the sensitivity of BAT cells to noradrenaline (NA) and β-adrenergic receptor (β-AR) signaling. This drives thermogenesis by fat and glucose oxidation via the actions of Ucp1. Sustained thermogenesis recruits additional fat and glucose from peripheral tissues for oxidation by BAT cells, which reduces fat storage in WAT as well as in undesirable locations such as skeletal muscle and the liver, thereby providing protection against obesity, skeletal muscle insulin resistance and NAFLD."


http://www.nature.com/nm/journal/v21/n2 ... .3797.html
 
Joined
Nov 26, 2013
Messages
7,367
Next thing they will say is that being the happiness hormone, being too happy can lead to fatness and diabetes. We need to suffer to be healthy, it's just the way god wills it, you guys.
 

haidut

Member
Joined
Mar 18, 2013
Messages
17,440
Location
USA / Europe
Waremu said:
Don't known if someone has already mentioned this recent news from this particular study here already or not, but definitely another point for Dr. Ray Peat.

"Obesity is a major risk factor for chronic disease. A new study in mice reveals that lowering levels of the signaling molecule serotonin outside of the brain reduces obesity and its complications by increasing brown adipose tissue (BAT) energy expenditure."

"Tryptophan (Trp) is converted into serotonin (5-HT) within the brain by the enzyme tryptophan hydroxylase (TPH)2, where it both increases sympathetic nervous system signaling to brown adipose tissue (BAT) and suppresses appetite. In the gastrointestinal tract (GIT), Trp is converted to serotonin by the enzyme Tph1. Crane et al.6 find that reducing circulating serotonin by inhibition of Tph1 or deletion of the Tph1 gene increases the sensitivity of BAT cells to noradrenaline (NA) and β-adrenergic receptor (β-AR) signaling. This drives thermogenesis by fat and glucose oxidation via the actions of Ucp1. Sustained thermogenesis recruits additional fat and glucose from peripheral tissues for oxidation by BAT cells, which reduces fat storage in WAT as well as in undesirable locations such as skeletal muscle and the liver, thereby providing protection against obesity, skeletal muscle insulin resistance and NAFLD."


http://www.nature.com/nm/journal/v21/n2 ... .3797.html

It is posted on the forum (several months ago), we discussed what drugs would work to achieve this effect. I posted a study on vitamin D inhibiting TPH-2 but the doses required to do it are very high. Something like mianserin or ketanserin may work better but would work differently than what the study recommends.
 

Waremu

Member
Thread starter
Joined
Feb 9, 2014
Messages
532
haidut said:
Waremu said:
Don't known if someone has already mentioned this recent news from this particular study here already or not, but definitely another point for Dr. Ray Peat.

"Obesity is a major risk factor for chronic disease. A new study in mice reveals that lowering levels of the signaling molecule serotonin outside of the brain reduces obesity and its complications by increasing brown adipose tissue (BAT) energy expenditure."

"Tryptophan (Trp) is converted into serotonin (5-HT) within the brain by the enzyme tryptophan hydroxylase (TPH)2, where it both increases sympathetic nervous system signaling to brown adipose tissue (BAT) and suppresses appetite. In the gastrointestinal tract (GIT), Trp is converted to serotonin by the enzyme Tph1. Crane et al.6 find that reducing circulating serotonin by inhibition of Tph1 or deletion of the Tph1 gene increases the sensitivity of BAT cells to noradrenaline (NA) and β-adrenergic receptor (β-AR) signaling. This drives thermogenesis by fat and glucose oxidation via the actions of Ucp1. Sustained thermogenesis recruits additional fat and glucose from peripheral tissues for oxidation by BAT cells, which reduces fat storage in WAT as well as in undesirable locations such as skeletal muscle and the liver, thereby providing protection against obesity, skeletal muscle insulin resistance and NAFLD."


http://www.nature.com/nm/journal/v21/n2 ... .3797.html

It is posted on the forum (several months ago), we discussed what drugs would work to achieve this effect. I posted a study on vitamin D inhibiting TPH-2 but the doses required to do it are very high. Something like mianserin or ketanserin may work better but would work differently than what the study recommends.


Thanks. I usually catch the stuff you post, but guess I dont remember seeing your post on it. Good to see the study nevertheless.
 

paymanz

Member
Joined
Jan 6, 2015
Messages
2,686
[ moderator edit: threads merged ]

Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis. - PubMed - NCBI

Abstract

Mitochondrial uncoupling protein 1 (UCP1) is enriched within interscapular brown adipose tissue (iBAT) and beige (also known as brite) adipose tissue, but its thermogenic potential is reduced with obesity and type 2 diabetes for reasons that are not understood. Serotonin (5-hydroxytryptamine, 5-HT) is a highly conserved biogenic amine that resides in non-neuronal and neuronal tissues that are specifically regulated via tryptophan hydroxylase 1 (Tph1) and Tph2, respectively. Recent findings suggest that increased peripheral serotonin and polymorphisms in TPH1 are associated with obesity; however, whether this is directly related to reduced BAT thermogenesis and obesity is not known. We find that Tph1-deficient mice fed a high-fat diet (HFD) are protected from obesity, insulin resistance and nonalcoholic fatty liver disease (NAFLD) while exhibiting greater energy expenditure by BAT. Small-molecule chemical inhibition of Tph1 in HFD-fed mice mimics the benefits ascribed to Tph1 genetic deletion, effects that depend on UCP1-mediated thermogenesis. The inhibitory effects of serotonin on energy expenditure are cell autonomous, as serotonin blunts β-adrenergic induction of the thermogenic program in brown and beige adipocytes in vitro. As obesity increases peripheral serotonin, the inhibition of serotonin signaling or its synthesis in adipose tissue may be an effective treatment for obesity and its comorbidities.
 
Last edited by a moderator:

Momado965

Member
Joined
Aug 28, 2016
Messages
919
It is posted on the forum (several months ago), we discussed what drugs would work to achieve this effect. I posted a study on vitamin D inhibiting TPH-2 but the doses required to do it are very high. Something like mianserin or ketanserin may work better but would work differently than what the study recommends.

Can lisuride work?
 

haidut

Member
Joined
Mar 18, 2013
Messages
17,440
Location
USA / Europe
Similar threads
Thread starter Title Forum Replies Date
Highserotonin90 Myostatin inhibition Experiments 0
Hgreen56 Eat No More That 1 Tsp Fat With A Meal To Prevent Inhibition Of The Oxidative Burning Of Sugar? Fats 1
Jake sullivan COVID-19 Mechanism Of Inflammation Through ACE2 Inhibition? Viruses, Parasites, Fungus, Vaccines 4
haidut Fatty Acid Oxidation (FAO) Inhibition Abrogates Triple-negative Breast Cancer Scientific Studies 2
Lewis Acid Evaluation Of Natural Products On Inhibition Of (COX-2) & Nitric Oxide Scientific Studies 0
Jake sullivan Tobacco Increases Serotonin Through MAO-A Inhibition? Alcohol, Tobacco, Drugs 21
H Vitamin K2 (MK4) And Aromatase Inhibition K 3
Lokzo Inhibition Of Androgen Receptor Can Decrease Fat Metabolism In Skeletal Muscles Of Trained Mice Scientific Studies 0
A How To Lower Inhibition (through Food, Supps) Besides Alcohol? Ask For Help or Advice 1
Hitchens Lion's Mane 5ar Inhibition Supplements, Pharmaceutical Drugs 7
superGrover Inhibition Of Estrogen Biosynthesis Enhances Lymphoma Growth In Mice Scientific Studies 3
E Inhibition Of Nitric Oxide Reverses Some Diabetes-induced Changes Scientific Studies 1
Black Ops Niacinamide FAO Inhibition Dose B3/Niacinamide 0
T How To Achieve 11β-HSD1 Inhibition In Tissues & Brain, But Avoid In Liver? Thyroid and Hormones 0
Constatine Aspirin Has Nootropic Properties Via Serotonin Inhibition Aspirin 5
Jon Baking Soda+Yogurt Lactic Acid Inhibition? Yoghurt, Kefir 4
raypeatclips Magnesium Protects Against Stress Induced Ulcers. Inhibition Of Stress Reactions Scientific Studies 0
Drareg Inhibition Of Sperm Motility And Agglutination Of Sperm Cells By Free Fatty Acids In Whole Semen Scientific Studies 6
haidut Inhibition Of PUFA Metabolism (LOX) Trigger Immediate Apoptosis In Prostate Cancer Scientific Studies 18
H Glycine Transporter-1 Inhibition Promotes Striatal Axon Sprouting Via NMDA Receptors In Dopamine Neu Scientific Studies 0
P Aromatase Inhibition Significanty Enhance Nerve Regeneration Articles & Scientific Studies 0
haidut Taurine Reverses Thyroid Inhibition Due To Fluoride Scientific Studies 51
whodathunkit Conundrum Of Coffee Luv And Acetylcholinesterase Inhibition Caffeine 16
Drareg Role Of G6PDH Inhibition In The Antiproliferative Effects Of DHEA Scientific Studies 1
P The Role Of Dopamine In Methylene Blue-mediated Inhibition Of Estradiol Benzoate-induced Anterior Pi Scientific Studies 4
P Inhibition of cardiac mitochondrial respiration by salicylic acid and acetylsalicylate. Articles & Scientific Studies 2
C Ornithine And Aromatase Inhibition Supplements 8
G Methylene Blue Inhibition Of Oestradiol-induced Increase Of Ceruloplasmin Serum Levels In Rats Scientific Studies 17
P Molecular Mechanisms Of DNA Repair Inhibition By Caffeine Articles & Scientific Studies 10
N Inhibition of Lipolysis Improves Glucose Metabolism, Insulin Sensitivity w/o Altering Fat Mass Scientific Studies 2
S Desaturase inhibition rejuvenates heart Articles & Scientific Studies 7
Blossom protective inhibition Ray Peat Quotes 2
K Inhibition of H. pylori in vitro by various berry extracts Articles & Scientific Studies 0
Lokzo Peripheral Regulation Of Sex Hormone Receptors Scientific Studies 0
D Peripheral Thyroid Conversion And Its Impact On TSH And Metabolic Activity Scientific Studies 1
PhilParma Peripheral Neuropathy, Rapidly Receding Gums + Bloods Blood Work, Labs 95
W Neutralizing Peripheral Nociceptors For Pain Relief? Cancer, Degenerative Diseases 1
D Peripheral Neuropathy Ask For Help or Advice 1
B Peripheral Edema/fluid Retention Caused By Magnesium Citrate? Ask For Help or Advice 20
S Uncoupler DNP Causing Peripheral Neuropathy, How? Pharmaceutical Drugs 29
haidut Lisuride Is A Potent Anti-histamine, And Peripheral Serotonin Antagonist Scientific Studies 12
A Octreotide Inhibits GH, Serotonin, Prolactin, TSH, Insulin Supplements, Pharmaceutical Drugs 0
Q Is Vitamin D induced serotonin syndrome possible? Please hear me out... Ask For Help or Advice 56
Mito Serotonin Pathway in Cancer Cancer 1
deliciousfruit I Think High Serotonin Is Holding Me Back Ask For Help or Advice 9
N The "safest" drug to increase serotonin Mental Issues 19
Mito Serotonin receptor 4 in the hippocampus modulates mood and anxiety Articles & Scientific Studies 0
Hans Anti-serotonin stack for more energy and well-being Articles & Scientific Studies 15
Mauritio 10-methoxy-harmalan ,an anti-serotonin chemical? IdeaLabs 34
Lokzo Vitamin B6 Increases Serotonin, Regardless of Serotonin Levels - PUBMED Supplements, Pharmaceutical Drugs 2

Similar threads

Top