dlind
Member
- Joined
- Sep 3, 2014
- Messages
- 10
wanted to share a couple of books I’ve come across that helped me understand serotonin
"You can't understand the other things that I'm working on unless you know where serotonin fits in. To understand unsaturated fatty acids vs. saturated, you have to understand estrogen and serotonin, and to understand thyroid, you have to understand all of those." —Ray Peat
Serotonin’s role in the carcinoid syndrome has been mentioned by Georgi and others. It was found that carcinoid tumors produced serotonin, causing symptoms like diarrhea and flushing.
If you’re interested in learning about the carcinoid syndrome and its relationship to serotonin, Albert Sjoerdsma’s daughter Ann has written a detailed biography of her father titled, “Starting with Serotonin”
In the late 50s, Albert Sjoerdsma and Sydney Udenfriend measured the urinary metabolite of serotonin—5-hydroxyindoleacetic acid, or 5-HIAA—in carcinoid patients through a chromatographic assay. Their findings indicated secretion of serotonin by carcinoid tumors. This elevated production of serotonin created symptoms like flushing, asthma, and intestinal hypermotility.
Another excellent book concerning serotonin—particularly on the development of the serotonin theory of depression—is “A Short History of Serotonin.” The book begins in 1868 with the discovery [by two German scientists] that coagulated blood produces increased vascular tone, and concludes with serotonin becoming a household name [in the late eighties] amid the marketing of Prozac.
These two reads have helped me put serotonin in context. I’ve come to a deeper understanding in learning about the early experiments surrounding serotonin. I recommend both books as they contain many interesting references and anecdotes.
"You can't understand the other things that I'm working on unless you know where serotonin fits in. To understand unsaturated fatty acids vs. saturated, you have to understand estrogen and serotonin, and to understand thyroid, you have to understand all of those." —Ray Peat
Serotonin’s role in the carcinoid syndrome has been mentioned by Georgi and others. It was found that carcinoid tumors produced serotonin, causing symptoms like diarrhea and flushing.
If you’re interested in learning about the carcinoid syndrome and its relationship to serotonin, Albert Sjoerdsma’s daughter Ann has written a detailed biography of her father titled, “Starting with Serotonin”
In the late 50s, Albert Sjoerdsma and Sydney Udenfriend measured the urinary metabolite of serotonin—5-hydroxyindoleacetic acid, or 5-HIAA—in carcinoid patients through a chromatographic assay. Their findings indicated secretion of serotonin by carcinoid tumors. This elevated production of serotonin created symptoms like flushing, asthma, and intestinal hypermotility.
Another excellent book concerning serotonin—particularly on the development of the serotonin theory of depression—is “A Short History of Serotonin.” The book begins in 1868 with the discovery [by two German scientists] that coagulated blood produces increased vascular tone, and concludes with serotonin becoming a household name [in the late eighties] amid the marketing of Prozac.
These two reads have helped me put serotonin in context. I’ve come to a deeper understanding in learning about the early experiments surrounding serotonin. I recommend both books as they contain many interesting references and anecdotes.