PUFA Is Vital For Cancer Progression; Restricting PUFA Can Be Therapeutic

haidut

Member
Joined
Mar 18, 2013
Messages
17,492
Location
USA / Europe
I don't think the findings of this study will come as a surprise to forum members but I think it is important to post it here as it is one of the few studies that points directly the finger at PUFA and calls it out by name. It is also the first study I have seen stating that reducing PUFA exposure could be therapeutic for cancer. Hopefully, we will see more studies like this come out soon.

Cyclooxygenase-derived proangiogenic metabolites of epoxyeicosatrienoic acids. - PubMed - NCBI
Study Reveals How Dietary Fats May Contribute To Tumor Growth - Egghead
UC Davis Researchers: The Potential To Block Cancer Growth May Have Been Found

"...Earlier research by the Judah Folkman laboratory of Harvard Medical School showed that cutting off blood vessels that feed a cancerous tumor can stop its growth. The seven-member research team—five from the Bruce Hammock laboratory of UC Davis—“characterized a novel lipid signaling molecule that can change fundamental biological processes involved in our health and disease,” said lead author and researcher Amy Rand. “We've found that a novel product derived from the metabolism of omega-6 fatty acids stimulates angiogenesis, which may contribute to enhanced tumor growth by providing tumors with oxygen and nutrients.”

"...“As a highly regulated process, angiogenesis is critical for wound healing and development, but many diseases result in unregulated angiogenesis, including cancer,” explained Rand, a postdoctoral fellow in the lab of Bruce Hammock, a distinguished professor who holds a joint appointment with UC Davis Department of Entomology and Nematology and the UC Davis Comprehensive Cancer Center. “We may be able to control angiogenesis to stimulate wound healing when necessary, but also block tumor growth in patients. Diseases that rely on angiogenesis may be able to be treated in part by changes in dietary lipid exposure or by controlling levels of these metabolites through enzyme inhibitors that block their formation.”

"...The research, published April 10 in the Proceedings of the Natural Academy of Sciences (PNAS), explains, in part, why inhibiting the soluble epoxide hydrolase (sEH) in some systems is angiogenic whereas combining sEH inhibition with the inhibition of cyclooxygenase (COX) enzymes is dramatically antiangiogenic, which in turn may suppress tumor growth."
 
Similar threads
Thread starter Title Forum Replies Date
H PUFA experiences Polyunsaturated Fats, Seed Oils 2
metabolizm Is Google pro-PUFA? Polyunsaturated Fats, Seed Oils 8
haidut PUFA promote torpor / hibernation, decrease lifespan Scientific Studies 10
haidut PUFA are potent immunosuppresive agents Scientific Studies 0
haidut Blocking PUFA/prostaglandins restores metabolism and reverses brain aging Scientific Studies 0
V Comparing PUFA in beans. Not so bad? Diet 9
Brandin vitamin e to balance eggs pufa. Polyunsaturated Fats, Seed Oils 15
M Organic Milk Contains More PUFA? Diet 3
I 2004 patent for low PUFA eggs Dairy, Eggs 24
Atma Ray Peat Interview #30: LSD, Serotonin, and Hallucinations | PUFA and Lipofuscin | Strategy of Tension | William Blake Interviews 4
ursidae >70 g of PUFA a day | Does diet even matter? Diet 72
haidut PUFA is catabolic, SFA is anti-catabolic (anabolic) Scientific Studies 0
DANIEL Anti-Peat Peat Wrong About PUFA? Debate - Anti-Peat 46
GelatinGoblin Which fish is best to eat in-terms of PUFA, Mercury? And maybe pollution, nuclear waste... Seafood 4
johnwester130 did my face change from k2 and avoiding PUFA? Health 84
lvysaur The Asian-Caucasoid PUFA dichotomy Scientific Studies 4
A PUFA (omega-7 Unsaturated Fatty Acids) Cause Of 'old People Smell' Polyunsaturated Fats, Seed Oils 3
Lokzo An Interview With Haidut (Georgi Dinkov) About PUFA's haidut 9
P Anti-Peat What Does Peat Have To Say About Tribal/indigenous Peoples Eating Pufa? Debate - Anti-Peat 22
A Pufa Detox - Vitamin E Polyunsaturated Fats, Seed Oils 6
Harryedgar Pufa Seems More Anabolic Than SAT Here - What Do Y’all Think? Polyunsaturated Fats, Seed Oils 4
johnwester130 Malassezia Turn Sebum Into PUFA - Is This Theory True? Hair & Nails 5
S Feeling Good After PUFA Polyunsaturated Fats, Seed Oils 5
haidut Dietary PUFA In Childhood Causes Diabetes And Irreversible (male) Infertility Scientific Studies 4
haidut PUFA Exacerbate, Saturated Fats (SFA) / Albumin / Calcium Ameliorate COVID-19 Scientific Studies 2
Razvan Pufa Deplition Is Amazing Mental Issues 82
Korven German Doctor Treats MS With Low PUFA Diet (Stops Disease In 84% Of Patients) Cancer, Degenerative Diseases 25
jamies33 Is Conjugated Linoleic Acid A PUFA? Milk 0
ecstatichamster Ray Peat Interview #35: CO2, Ketosis, And Mitochondria | PUFA, Sugar, Iron, And AGEs | Progesterone And Cell Stabil Danny Roddy 21
Harryedgar Fat Loss, PUFA, Estrogen Detox And Increased Metabolism Weight 0
haidut Dietary PUFA Causes (reversible) Male Infertility And Androgen Deficiency Scientific Studies 4
N Anti-Peat Saturated Fat TERRIBLE For Liver Health & Diabetes. Compared To PUFA Debate - Anti-Peat 140
lyfe Does Conventional Milk Contain PUFA? Diet 4
koreus Tearful After Reducing Stress And Cortisol By Removing PUFA Cortisol, Serotonin, Histamine 11
D Firebrand Meats - Low PUFA Pork Meat 5
D Low Pufa, Plant Based + Lean Wild Meat? Better Metabolism? Diet 10
N PUFA Chart? Ask For Help or Advice 4
wealthofwisdom What Specific PUFA Foods Did You Remove From Your Diet? Diet 49
L PUFA Detox? Metabolism 3
T Is There Are An Effective Way Clean PUFA Oil From Canned Oysters? Meat, Organ Meat, Gelatin, Seafood 5
J Why Does Peat Say Beef Is Low PUFA? Studies Are Contrary. I Don't Get It Meat 6
haidut PUFA Are Toxic/carcinogenic, And That Has Been Known For Decades Scientific Studies 5
haidut Striking Accumulation Of PUFA In Aged Cells Scientific Studies 10
haidut PUFA May Be A Major Factor In Sterility Scientific Studies 0
haidut PUFA Increases Risk Of All Cancers, Especially Prostate Scientific Studies 0
haidut Diet (PUFA) Causes Inflammatory Bowel Disease (IBD) Scientific Studies 0
haidut PUFA Is A Cancer "sensitizer" Scientific Studies 0
haidut PUFA Makes Girls Fat / Lazy / Diabetic And Exercise Futile Scientific Studies 13
haidut Nut (PUFA) Consumption May Cause Diabetes Even Without Obesity Scientific Studies 0
haidut PUFA Increases Risks Of Skin Cancers Scientific Studies 0

Similar threads

Top