Pentoxifylline Explores New Horizons In Treatment Of Hashimoto Thyroiditis

Discussion in 'Articles & Scientific Studies' started by paymanz, Feb 12, 2017.

  1. paymanz

    paymanz Member

    Jan 6, 2015

    Hashimoto Thyroiditis is an autoimmune disease and the most common cause of hypothyroidism in developed countries. As the disease initiates unusual thyroidal antigens are exposed to the immune system. The immune system sensitizes to those antigens and creates a cell mediated autoimmune response against thyroid gland. Inflammatory cells infiltrate within thyroid follicles and destruct the follicles by inflicting oxidative stress and inducing apoptosis. The inflammatory process also reduces sensitivity of thyrocytes to Thyroid Stimulating Hormone (TSH). As the disease progresses and the follicles degrade, fibrotic tissue replaces the follicles until the whole gland becomes fibrotic. Pentoxiflline could inhibit autoimmune destruction of thyrocytes, suppress cell mediated immune response against thyroid, decrease oxidative damage to thyrocytes, increase sensitivity of thyrocytes to TSH and hinder fibrotic degeneration of thyroid. Thereby PTX could cure HT and alleviate symptoms of hypothyroidism.

    All clues together, PTX is an anti-inflammatory/anti-oxidant agent and it may reduce inflammation and aberrant apoptosis of thyroid epithelial cells. It may reduce exposure of intra cellular/follicular components to immune system and decrease infiltration of leukocytes within thyroid follicles. It may ameliorate decreased responsiveness of throcytes to TSH. PTX may accelerate regeneration of damaged thyrocytes as it suppresses IFN-γ and up-regulates production of IL-10 and it also inhibits fibrosis of the gland. All in all PTX may have curative effects on HT and may have the potential to become an alternative treatment. Evaluation of the issue with clinical researches and cohort large studies are necessarily needed to validate/invalidate the hypothesis.