- Joined
- Aug 24, 2017
- Messages
- 5,858
"To move, muscles need energy in the form of ATP, adenosine triphosphate. Most people think glucose, a sugar, supplies this energy, but during intense exercise, it's too little and too slow as an energy source, forcing muscles to rely on glycogen, a carbohydrate stored inside muscle cells"
"He postulated an "intracellular lactate shuttle" that transports lactate from the cytoplasm, where lactate is produced, through the mitochondrial membrane into the interior of the mitochondria, where lactate is burned. In 2000, he showed that endurance training increased the number of lactate transporter molecules in mitochondria, evidently to speed uptake of lactate from the cytoplasm into the mitochondria for burning."
https://www.sciencedaily.com/releas...tm_campaign=ScienceDaily_TMD_1&utm_source=TMD
It doesn't make sense that the body would rather make lactate just to transport it into the mitochondria to be used as energy, whereas pyruvate could have done it right away. And proper oxidative metabolism produces 13 times more ATP than lactate.
I have also seen a study that shows that during exercise at around 70% intensity, the body produces lactate even in the presence of enough oxygen.
I think this is because there is a lack of B1 and maybe biotin, so glucose cannot enter the TCA cycle fast enough, thus it converts to lactic acid which can enter the mitochondria without being inhibited by a nutritional deficiency?
I remember @haidut mentioning once that he recommended high dose B1 to a coworker that did endurance training and it really improved his performance when he used it. So much for lactic acid being a better or prefered fuel.
I think another reason the body might want to make lactic acid, is because it converts NADH back to NAD thus improving the redox status of the cell. Again, nutritional deficiency.
I just think it's ridiculous that more studies are showing how "beneficial" lactate is and that the body prefers it over glucose, which I think is just the cause of vitamin deficiencies.
"He postulated an "intracellular lactate shuttle" that transports lactate from the cytoplasm, where lactate is produced, through the mitochondrial membrane into the interior of the mitochondria, where lactate is burned. In 2000, he showed that endurance training increased the number of lactate transporter molecules in mitochondria, evidently to speed uptake of lactate from the cytoplasm into the mitochondria for burning."
https://www.sciencedaily.com/releas...tm_campaign=ScienceDaily_TMD_1&utm_source=TMD
It doesn't make sense that the body would rather make lactate just to transport it into the mitochondria to be used as energy, whereas pyruvate could have done it right away. And proper oxidative metabolism produces 13 times more ATP than lactate.
I have also seen a study that shows that during exercise at around 70% intensity, the body produces lactate even in the presence of enough oxygen.
I think this is because there is a lack of B1 and maybe biotin, so glucose cannot enter the TCA cycle fast enough, thus it converts to lactic acid which can enter the mitochondria without being inhibited by a nutritional deficiency?
I remember @haidut mentioning once that he recommended high dose B1 to a coworker that did endurance training and it really improved his performance when he used it. So much for lactic acid being a better or prefered fuel.
I think another reason the body might want to make lactic acid, is because it converts NADH back to NAD thus improving the redox status of the cell. Again, nutritional deficiency.
I just think it's ridiculous that more studies are showing how "beneficial" lactate is and that the body prefers it over glucose, which I think is just the cause of vitamin deficiencies.