ebs
Member
Increasing dopamine has been shown to help. A lower dose of a GABA agonist like progesterone may also work by reducing anxiety.
There's probably nothing better for public speaking than Phenibut.
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Increasing dopamine has been shown to help. A lower dose of a GABA agonist like progesterone may also work by reducing anxiety.
How about androsterone as the GABA agonist for these situations? I wonder if the social reactions would be positive or negative for me in a (sales) presentation. I suppose it would depend on the hormonal status of the people attending. It would probably be too much of a wildcard. What are your thoughts?
im sorry if this has been asked before, but is there a product of yours that you would specifically use for adrenal hyperacativity? like to tame the adrenals if you will? @haidut
Sweet. i ordered gonadin a few days ago, really excited to try it. and is there a "wrong" way treat it too?Adrenals are usually overactive when thyroid is low. So, the "right" way to tame them would be to improve thyroid function. If the person has excess cortisol due to Cushing or high estrogen then something like progesterone/DHEA, aspirin, cyproheptadine or even Gonadin may help.
Sweet. i ordered gonadin a few days ago, really excited to try it. and is there a "wrong" way treat it too?
Just wanted to say thanks for the quick shipment Haidut. I placed the order Sunday night and got it today. I am excited to try these products and will give feedback on them.
JAK inhibitor for hair regrowth ??
It's the latest trend
JAK inhibitor for hair regrowth ??
It's the latest trend
Btw @haidut I was browsing this thread, and came across a portion discussing 5-HT1A antagonists. Did you ever look further into those (or 5-HT4 agonists, 5-HT7 antagonists, 5-HT6 agonists/antagonists, etc. — the popular stuff being researched)? Selective (or just without 5-HT1D activity) 5-HT1B agonists look equally interesting (for depression, especially).
I am not interested in selectivity. Non-selectivity is usually a sign of a beneficial chemical. Be that as it may, both cyproheptadine and metergoline are 5-HT1 antagonists.
@haidut
I realized that with the USPS mailing option you are using, I can track the package the whole way from DC to my home in Spain. This always worked for packages sent by DHL, FedEx, etc. that are always in the custody of the package but it NEVER happened with USPS because packages sent by USPS, once the package reaches Spain, it is handled to public national mail company, which somehow never crossed delivery status with USPS, so once the package reached Spain, there was no way to know where that package was. Now it works. Thy somehow communicate to each other so I can follow the package door to door. GREAT!!! Thanks!
Yes, the tracking should cover the entire route but it is not always very detailed. But at least you will know when it reached your country and then it was delivered.
So far it's looking like Makrosky's previous experience. My package was due a week ago. Our post office here in South Africa doesn't recognize the tracking number, suggests I look it up on USPS which I did, and got a very detailed list of the many places it went through in the US before leaving on the 23rd of May, after which, silence. I only have a call centre option here for queries, that's what I'll do tomorrow probably.
That is encouraging! Thanks. I should have clarified that it is the Post Office website that doesn't recognize the tracking number, but it's very likely to be out of date.I had a few packages to SA eventually show up in the tracking system even though the postal people claim their system does not recognize the numbers. So, hopefully yours shows up soon too.
Any chance of a follow up to this?Is there any good info on the safety of SFA esters? Do they all share similar safety levels? I understand that you don't want people copying the products, but I know personally the only thing stopping me from buying them is not knowing the specific SFA ester. the ideas behind all the combinations are novel and good, some of the products I can't easily get elsewhere (like concentrated emodin)... but it's just not being able to know what I ingest that is keeping me from pulling the trigger and buying a bunch of these products
Any chance of a follow up to this?
Yes, there is a follow up. The SFA esters we use are a combination of isopropyl myristate (IPM) and stearyl alcohol. The stearyl alcohol is well known to the forum and so is myristic acid. IPM is perhaps one of the most widely used transdermal enhancers for creams and pharmaceuticals. There is a lot of information about it on Pubmed. It seems especially well-suited for transdermal formulations involving steroids.
Isopropyl myristate - Wikipedia
IPM is just the ester of isopropyl alcohol with myristic acid. Myristic acid is an SFA found in coconut oil while isopropyl alcohol is commonly known as "rubbing alcohol". I don't think the safety of stearyl alcohol or myristic acid need any explanations, so I will focus on isopropyl alcohol. Each drop of one of the products using the SFA esters + ethanol solvent has about 2mg isopropyl alcohol (from the IPM). Here is a document describing the safety profile of isopropyl alcohol by transdermal, oral, ocular, etc routes. To experience any toxicity symptoms, humans typically needed to get exposed to multigram amounts.
ISOPROPYL ALCOHOL - Emergency and Continuous Exposure Limits for Selected Airborne Contaminants - NCBI Bookshelf
Here is a human study showing that actual ingestion of pure isopropyl alcohol in doses up to 6.4mg/kg for 6 weeks did not produce any toxic effects. This amounts to daily ingestion of 400mg-800mg isopropyl alcohol for more than a month.
Effects on man of daily ingestion of small doses of isopropyl alcohol - ScienceDirect
Moreover, isoropyl alcohol is used as food ingredient in many foods and drinks we consume on a daily basis, especially sodas. See below.
Isopropyl Alcohol in Soft Drinks - SourceWatch
"...In September 2005, a "panel of scientific experts" at the European Food Safety Authority concluded, "after examining a dossier on propan-2-ol (isopropanol, IPA) put forward by the European Flavour and Fragrance Association (EFFA), [that] soft drink makers should propose limits for heavy metals and aromatic hydrocarbons used as carrier solvents for flavouring preparations in soft drinks." [1]The EFSA said that the Acceptable Daily Intake (ADI) of "2.4 mg/kg bw would be reached for a 60 kg [approximately 132-pound] adult by the daily consumption of 240 ml of soft drink which is less than a normal sized can or bottle." [2]The EFSA stated that an "estimate has been made of the potential intake of propan-2-ol from all sources for UK adult consumers, including the assumption that it is used in soft drinks at 600 mg/l. The mean potential intake was estimated to be 1.3 mg/kg bw/day, i.e. below the ADI. However, the estimated 97.5th percentile of potential intake from all sources in consumers was 5.4 mg/kg bw/day, exceeding the ADI. Exposure estimates based only on the consumption of regular carbonated drinks in teenagers from 5 EU cities, assuming a concentration of 600 mg/l, lead to potential intake of 1.4 mg/kg bw/day at the mean and up to 10 mg/kg bw/day at the 97.5th percentile." [3]"
So, the daily internal exposure (ingestion) most people get from food/drinks and other sources is in the 350mg-700mg range (i.e. about 5.4mg/kg as study above says).
For comparison, an entire bottle of say Calricol has about 500mg isopropyl alcohol in it, and a bottle of Pansterone has about 720mg. A daily usage of our products would provide exposure to anywhere from 2mg (1 drop) to 25mg (12 drops). This is an order of magnitude lower than the oral exposure in humans, which has not been shown to cause any issues. Anybody using rubbing alcohol on their skin gets an order of magnitude higher exposure to isopropyl alcohol than what they would get from the supplements. Of course, there could be people who are especially sensitive to IPM but so far I have not received any reports on irritation of other toxicities.
I hope that helps.