Idealabs Comments And Suggestions

Discussion in 'IdeaLabs' started by Ras, Feb 25, 2016.

  1. haidut

    haidut Member

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    Yep, thanks for saying this. One of the reasons I have reservations about this chemical and other highly specific 5-Ht1A antagonists. Many other 5-HT1A receptor antagonists were dropped from considerations due to issued with side effects. In fact, one of them was specifically tested for reversing the effects of SSRI but the clinical trial failed.
    Robalzotan - Wikipedia

    The ones that look more promising are these:
    NAN-190 - Wikipedia
    Isamoltane - Wikipedia
    Dotarizine - Wikipedia
     
  2. Brooks Esq.

    Brooks Esq. Member

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    All of these have been looked into before, NAN-190 was actually used in an experiment; none of these substances affect the 5ht1a post synaptic receptor, and they are no benefit to PSSD research or cognitive enhancement; NAN-190 is actually extremely dangerous and our test subject ended up getting admitted to hospital. Lecozotan and WAY are the only two that are safe for research, they have been used on humans for years and Lecozotan even made it through phase III clinical trials in humans. So it is best for our research purposes.

    And to the concern about excitotoxic effects at parasympathetic, that effect is actually of great benefit to PSSD sufferers and is what we need to do! It's what makes Lecozotan perfect. Whatever 5ht1a antagonist we decide on, I would like to see a pubmed study verifying it's effects at the 1a post synaptic. I have looked all over and have ALWAYS come back to WAY 100635 or Lecozotan; there really is no short cut.
     
  3. Brooks Esq.

    Brooks Esq. Member

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    Honestly, this is exactly was is needed to combat the brain fog and cognitive effects associated with PSSD; this is exactly what we want to some degree. It's what makes Lecozotan so perfect
     
  4. haidut

    haidut Member

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    Have you considered this?
    New Drug Treats Depression in Less Than 24 Hours With Minimal Side Effects
     
  5. Brooks Esq.

    Brooks Esq. Member

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    Yes we have reviewed that before. We believe PSSD is caused by a desensitation of the 5ht1a post synaptic receptor at its core, and all the resulting issues such as Gaba, sodium ion channels, hormones, etc are all secondary effects. So the effects that new drug is treating will all be solved with the administration of a potent 5ht1a antagonist.
     
  6. haidut

    haidut Member

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    OK, noted. I am looking into this.
     
  7. DaveFoster

    DaveFoster Member

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    I'd really like famotidine; it has a ton of benefits, including safeguarding against ulcers in favor of the most powerful drug ever, aspirin.

    Famotidine is very slightly water-soluble, and moreso in acetic acid, but when I dissolve it, I always get some of the nasty excipients in the pill no matter what, so it would be nice to have a pure supplement.
     
  8. charlie

    charlie The Law & Order Admin

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    :+1
     
  9. DaveFoster

    DaveFoster Member

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    @haidut

    In addition to the famotidine, mildronate would be very interesting to try. It's on the market, but it's ridiculously expensive and maybe a topical version would be more cost effective.

    CO2 elevation, focus, clarity, performance enhancement, and protection against vascular disease sounds pretty Peaty to me.
     
  10. High_Prob

    High_Prob Member

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    Homotaurine...
     
  11. haidut

    haidut Member

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    I am actually looking at another fatty acid oxidation inhibitor similar to Mildronate, which uses much lower doses to achieve the same.
     
  12. Koveras

    Koveras Member

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  13. haidut

    haidut Member

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  14. Such_Saturation

    Such_Saturation Member

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  15. Amazoniac

    Amazoniac Member

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    Absolutely!
    Read here so you can grasp the discussion, if you haven't yet.
    The guys from tissue mineral analysis constantly mention zinc as one of the few minerals that they often recommend supplementing; that says a lot because they are fixated on trace minerals. Zinc picolinate is the form used as far as I know.
    A release like that would definitely throw a haiduken on the other questionable products available.

    Wish you both a nice christmas. :grouphug
     
  16. DaveFoster

    DaveFoster Member

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    I would certainly try it out. Hopefully it will be easier on the liver than high-dose niacinamide.
     
  17. Koveras

    Koveras Member

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  18. Makrosky

    Makrosky Member

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    @haidut

    I realized that with the USPS mailing option you are using, I can track the package the whole way from DC to my home in Spain. This always worked for packages sent by DHL, FedEx, etc. that are always in the custody of the package but it NEVER happened with USPS because packages sent by USPS, once the package reaches Spain, it is handled to public national mail company, which somehow never crossed delivery status with USPS, so once the package reached Spain, there was no way to know where that package was. Now it works. Thy somehow communicate to each other so I can follow the package door to door. GREAT!!! Thanks!
     
  19. johnwester130

    johnwester130 Member

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    all the plastic bottles should be replaced with glass ones, with users using their own dropper.
     
  20. haidut

    haidut Member

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    Yes, the tracking should cover the entire route but it is not always very detailed. But at least you will know when it reached your country and then it was delivered.
     
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