Ibuprofen Shrinks Testicles, Lowers Testosterone, Linked To Infertility
herculeanstrength.com
In 2018, it was estimated that 15% of Americans take too much Ibuprofen — with the recommended daily limit being 3200mg per day. Additionally, Americans take an estimated 30 billion doses of painkillers similar to and including Ibuprofen which totals 16.5 million prescriptions.
Researchers from Denmark and France found in the paper Proceedings of the National Academy of Sciences that prolonged use of the commonly consumed painkiller could have some nasty side effects.
Net Doctor reported: “The small study, made up of just 31 male participants aged 18 to 35 years old, showed that taking ibuprofen increased the risk of compensated hypogonadism – a hormone imbalance whereby an individual has higher levels of luteinizing hormone (LH) than testosterone.
“For the research, participants were split into two groups. one group received 600mg or ibuprofen twice a day two weeks before and 30 days after an exercise session while the other acted as a control group. For the ibuprofen group, blood tests showed an 18% decrease in testosterone after 14 days, rising to a 23% decrease after 44 days.”
What is particularly alarming about the study is the participants were consuming around a third of what is considered a safe daily dose.
Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism
pubmed.ncbi.nlm.nih.gov
Abstract
Concern has been raised over increased male reproductive disorders in the Western world, and the disruption of male endocrinology has been suggested to play a central role. Several studies have shown that mild analgesics exposure during fetal life is associated with antiandrogenic effects and congenital malformations, but the effects on the adult man remain largely unknown. Through a clinical trial with young men exposed to ibuprofen, we show that the analgesic resulted in the clinical condition named "compensated hypogonadism," a condition prevalent among elderly men and associated with reproductive and physical disorders. In the men, luteinizing hormone (LH) and ibuprofen plasma levels were positively correlated, and the testosterone/LH ratio decreased. Using adult testis explants exposed or not exposed to ibuprofen, we demonstrate that the endocrine capabilities from testicular Leydig and Sertoli cells, including testosterone production, were suppressed through transcriptional repression. This effect was also observed in a human steroidogenic cell line. Our data demonstrate that ibuprofen alters the endocrine system via selective transcriptional repression in the human testes, thereby inducing compensated hypogonadism.
Ibuprofen Shrinks Testicles, Lowers Testosterone, Linked to Infertility
The commonly prescribed painkiller and anti-inflammatory, ibuprofen, has been linked to shrinking testicles, lowered testosterone levels and infertility issue in a shocking study. With plummeting testosterone levels and skyrocketing infertility levels, the revelation adds fuel to the fire, as...
herculeanstrength.com
In 2018, it was estimated that 15% of Americans take too much Ibuprofen — with the recommended daily limit being 3200mg per day. Additionally, Americans take an estimated 30 billion doses of painkillers similar to and including Ibuprofen which totals 16.5 million prescriptions.
Researchers from Denmark and France found in the paper Proceedings of the National Academy of Sciences that prolonged use of the commonly consumed painkiller could have some nasty side effects.
Net Doctor reported: “The small study, made up of just 31 male participants aged 18 to 35 years old, showed that taking ibuprofen increased the risk of compensated hypogonadism – a hormone imbalance whereby an individual has higher levels of luteinizing hormone (LH) than testosterone.
“For the research, participants were split into two groups. one group received 600mg or ibuprofen twice a day two weeks before and 30 days after an exercise session while the other acted as a control group. For the ibuprofen group, blood tests showed an 18% decrease in testosterone after 14 days, rising to a 23% decrease after 44 days.”
What is particularly alarming about the study is the participants were consuming around a third of what is considered a safe daily dose.
Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism
Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism - PubMed
Concern has been raised over increased male reproductive disorders in the Western world, and the disruption of male endocrinology has been suggested to play a central role. Several studies have shown that mild analgesics exposure during fetal life is associated with antiandrogenic effects and...
pubmed.ncbi.nlm.nih.gov
Abstract
Concern has been raised over increased male reproductive disorders in the Western world, and the disruption of male endocrinology has been suggested to play a central role. Several studies have shown that mild analgesics exposure during fetal life is associated with antiandrogenic effects and congenital malformations, but the effects on the adult man remain largely unknown. Through a clinical trial with young men exposed to ibuprofen, we show that the analgesic resulted in the clinical condition named "compensated hypogonadism," a condition prevalent among elderly men and associated with reproductive and physical disorders. In the men, luteinizing hormone (LH) and ibuprofen plasma levels were positively correlated, and the testosterone/LH ratio decreased. Using adult testis explants exposed or not exposed to ibuprofen, we demonstrate that the endocrine capabilities from testicular Leydig and Sertoli cells, including testosterone production, were suppressed through transcriptional repression. This effect was also observed in a human steroidogenic cell line. Our data demonstrate that ibuprofen alters the endocrine system via selective transcriptional repression in the human testes, thereby inducing compensated hypogonadism.
