Manganese acts centrally to activate reproductive hormone secretion and pubertal development in male rats

[Lucenzo01]

Abstract​

Manganese (Mn) is an important element for normal growth and reproduction. Because Mn accumulates in the hypothalamus and is capable of stimulating puberty-related hormones in female rats, we assessed whether this metal could cause similar effects in male rats. We have demonstrated that MnCl2, when administered acutely into the third ventricle of the brain, acts dose dependently to stimulate luteinizing hormone (LH) release. Furthermore, there was a dose dependent stimulation in the secretion of LH-releasing hormone (LHRH) from the medial basal hypothalamus in vitro, and administration of an LHRH receptor antagonist in vivo blocks Mn-induced LH release. To assess potential chronic effects of the metal, male pups were supplemented with 10 or 25 mg MnCl2 per kg by gastric gavage from day 15 until days 48 or 55, at which times developmental signs of spermatogenesis were assessed. Results demonstrate that while significant effects were not observed with the 10 mg/kg dose, the animals receiving the 25 mg/kg dose showed increased LH (p<0.05), FSH (p<0.01) and testosterone (p<0.01) levels at 55 days of age. Furthermore, there was a concomitant increase in both daily sperm production (p<0.05) and efficiency of spermatogenesis (p<0.05), demonstrating a Mn-induced acceleration in spermatogenesis. Our results suggest Mn is a stimulator of prepubertal LHRH/LH secretion and may facilitate the normal onset of male puberty. These data also suggest that the metal may contribute to male precocious pubertal development should an individual be exposed to low but elevated levels of Mn too early in life.

 

[Rinse & rePeat]

“Manganese. This mineral has well documented aphrodisiac effects, first observed on a large scale amongst manganese miners in Chile. Unfortunately, the miners, who inhaled the ore dust in the course of their work were pleased by their enhanced sexual powers and kept on mining. Ultimately the toxic overload of manganese caused damage to nerve cells, rendering some of the men impotent and suffering with permanent nerve damage and parkinsonism. Nevertheless, taking manganese supplements by mouth is not dangerous and the likelihood of improved libido and sexual performance is so high that manganese is worth a try in all who feel that they need a "lift."”

Sex and Nutrition

Health and sex go together. In fact, loss of sexual desire and function is a sign of physical illness and mental depression. Anyone afflicted with loss of sexual responsiveness should seek a medical evaluation. While illness is not commonly found in cases where loss of libido is the sole presenting

www.olaloa.com

 

[ecstatichamster]

I think boron is perhaps a bit safer. But I’ve been experimenting with metals lately, so I’m going to try 8mg a day of manganese.

Thank you for the study!

 

[ecstatichamster]

You don’t want too much.

Manganese-Stimulated Kisspeptin Is Mediated by the IGF-1/Akt/Mammalian Target of Rapamycin Pathway in the Prepubertal Female Rat

Low-dose administration of manganese chloride (MnCl[2] ) causes release of hypothalamic LH-releasing hormone (LHRH) and advances puberty in rat. Recently, this element was shown to up-regulate mammalian target of rapamycin (mTOR), kisspeptin gene (KiSS-1), ...

www.ncbi.nlm.nih.gov

Low-dose administration of manganese chloride (MnCl2) causes release of hypothalamic LH-releasing hormone (LHRH) and advances puberty in rat. Recently, this element was shown to up-regulate mammalian target of rapamycin (mTOR), kisspeptin gene (KiSS-1), and LHRH gene expressions in the brain preoptic area (POA)/anteroventral periventricular (AVPV) nucleus. Because these genes are critical for puberty, this study was conducted to identify the upstream mechanism by which Mn activates the mTOR/KiSS-1 pathway. On day 12, immature female rats began receiving a daily supplemental dose of 10 mg/kg of MnCl2 or saline by gavage, and POA/AVPV tissues were collected on day 29 for specific protein assessments. Another experiment assessed in vitro IGF-1 release in response to Mn and assessed signal transduction pathways in the POA/AVPV region after Mn delivery into the third ventricle. Chronic Mn exposure increased (P < .05) basal expressions of mTOR and kisspeptin proteins. Mn increased protein kinase B (Akt) and Ras homolog enriched in brain, both capable of activating mTOR. Central Mn delivery increased expressions of phosphorylated IGF-1 receptor (IGF-1R) (P < .05) and Akt (P < .01) in the POA/AVPV region. The previous central delivery of JB1, an IGF-1R antagonist, blocked Mn-induced expressions of both phosphorylated IGF-1R and Akt. Downstream to Akt, centrally administered Mn increased tuberous sclerosis complex 2 (P < .05), Ras homolog enriched in brain (P < .01), mTOR (P < .05), and kisspeptin (P < .05). Finally, we observed that the early puberty induced by Mn was blocked by the administration of an mTOR inhibitor. These results suggest that Mn acts, at least in part, through the IGF-1/Akt/mTOR pathway to influence prepubertal kisspeptin and LHRH.

 

[David PS]

You don’t want too much.

I agree. I get my Mn from maple syrup.

 

[Rinse & rePeat]

I agree. I get my Mn from maple syrup.

I eat a lot of maple syrup. It goes well on cottage cheese topped with marmalade, with a pinch of salt, in coffee, and on butter fried and salted eggs. I use maple sugar in my baked custard, and am going to try it on sprouted oatmeal, with fresh orange peel cooked into it too.