Higher Intake Of Vitamin E As A Child May Prevent Liver Disease Later On

haidut

Member
Joined
Mar 18, 2013
Messages
17,548
Location
USA / Europe
I think most people on this forum know about the link between estrogen and liver disease. Peat has written at length about it and there is officially published data spanning more than century showing that (just like "autoimmune" conditions) liver disease has much higher incidence in women, thus exposing the role of estrogen. One of the most potent natural antagonists of estrogen, both at the receptor level and by inhibiting aromatase, is vitamin E. So, one would expect to find protective effect of vitamin E on the development and progression of liver disease.
This new study found exactly that, and more importantly, that the link between vitamin E and liver health begins in early childhood. Most doctors/pediatricians are squarely against vitamin E supplementation for kids, but given that not many foods are fortified with it any more I think this recommendation may have to change.

Association of Vitamin E Intake at Early Childhood with Alanine Aminotransferase Levels at Mid‐Childhood
https://www.healio.com/hepatology/s...ake-linked-to-liver-health-later-in-childhood

"...“Early and mid-childhood could be key windows of opportunity to prevent rising ALT levels. Moreover, identifying protective factors against elevated ALT levels could inform future interventions to prevent pediatric [non-alcoholic fatty liver disease (NAFLD)],” Jennifer A. Woo Baidal, MD, MPH, from the division of pediatric gastroenterology, hepatology and nutrition at Columbia University Medical Center and colleagues wrote. “Vitamin E is a prime candidate for protection against development of NAFLD. ... Identifying the prospective association of alpha-tocopherol intake during early childhood with later ALT levels could inform future efforts to prevent liver damage in children.”

"...“Our results extend the existing literature showing alpha-tocopherol treatment effect in established NAFLD to suggest that alpha-tocopherol intake early in childhood could have a protective role against liver injury later in childhood,” they wrote. “Modifiable risk factors, specifically intake of vitamin E, should be considered in future interventions to identify approaches to prevent pediatric NAFLD.”"
 

Tarmander

Member
Joined
Apr 30, 2015
Messages
3,508
It’s very tough to get the RDA of E without supplementing. It is always low when I put my diet into crono, especially because nuts are pretty much out. I guess you could try milling your own grains to get the natural E before it degrades?
 

haidut

Member
Thread starter
Joined
Mar 18, 2013
Messages
17,548
Location
USA / Europe
It’s very tough to get the RDA of E without supplementing. It is always low when I put my diet into crono, especially because nuts are pretty much out. I guess you could try milling your own grains to get the natural E before it degrades?

Grains may help but liver is probably a safer source of vitamin E, and it can be eaten once weekly and still provide enough vitamin E for up to 2 weeks.
 

RobertJM

Member
Joined
Sep 16, 2017
Messages
413
The cronometer says there is barely any vitamin E in 50g of lambs liver (0.35mg), especially with the amount of iron that comes with it. But who can say that the cronometer is anything accurate.

For me, it just seems that any food with higher amounts of vitamin E usually has a heavy load of PUFA along with it. Almost like Mother Nature put it there to protect (to some degree) against the PUFA poison.
 

Tarmander

Member
Joined
Apr 30, 2015
Messages
3,508
Grains may help but liver is probably a safer source of vitamin E, and it can be eaten once weekly and still provide enough vitamin E for up to 2 weeks.
That is interesting. Do you think freezing would damage the vitamin e at all?
 

haidut

Member
Thread starter
Joined
Mar 18, 2013
Messages
17,548
Location
USA / Europe
That is interesting. Do you think freezing would damage the vitamin e at all?

It should not. Prolonged cooking may do some damage but should still leave most of it intact.
 

haidut

Member
Thread starter
Joined
Mar 18, 2013
Messages
17,548
Location
USA / Europe
The cronometer says there is barely any vitamin E in 50g of lambs liver (0.35mg), especially with the amount of iron that comes with it. But who can say that the cronometer is anything accurate.

For me, it just seems that any food with higher amounts of vitamin E usually has a heavy load of PUFA along with it. Almost like Mother Nature put it there to protect (to some degree) against the PUFA poison.

I don't think cronometer takes into account all of the vitamin E isomers, I think it tracks only alpha tocopherol. Also, it does not take into account various metabolites of vitamin E like tocopheryl-quinone, which are metabolized back into vitamin E once ingested. Biopsies done on humans show much higher concentrations of vitamin E per gram of liver tissue. Not encouraging cannibalism in any way, but if this is true and grazing animals have even more vitamin E than us stored in their liver something is amiss with those numbers from cronometer.
 

RobertJM

Member
Joined
Sep 16, 2017
Messages
413
I don't think cronometer takes into account all of the vitamin E isomers, I think it tracks only alpha tocopherol. Also, it does not take into account various metabolites of vitamin E like tocopheryl-quinone, which are metabolized back into vitamin E once ingested. Biopsies done on humans show much higher concentrations of vitamin E per gram of liver tissue. Not encouraging cannibalism in any way, but if this is true and grazing animals have even more vitamin E than us stored in their liver something is amiss with those numbers from cronometer.

Wow that's interesting stuff. Thanks, Haidut.

Without meaning to digress too much, Ray (I'm fairly sure) once said that liver was one of the cleanest organs to eat? Not sure if I have that right. But it's not the main organ that detoxifies? How can it be the cleanest organ to eat? It's just one of a million questions I would love to ask Ray, but I am not lucky enough to have his email. Not sure if you have an opinion on it?
 

Tenacity

Member
Joined
Mar 12, 2016
Messages
781
@haidut On Danny Roddy's Generative Energy podcast regarding autoimmunity, you said that liver disease is a common co-morbidity of autoimmune disease. Do you think this mean that vitamin E would help with autoimmune conditions, too?
 
Similar threads
Thread starter Title Forum Replies Date
haidut Higher vitamin K intake reduces all-cause mortality risk Scientific Studies 0
haidut Higher intake of vitamin K inversely tied to mortality risk Scientific Studies 2
Amazoniac Ideal Copper Intake May Be Higher Than What's Currently Recommended Minerals 33
Fractality Other Minerals To Balance A Higher Than Normal Calcium Intake? Ask For Help or Advice 6
R High Carbohydrate Intake Was Associated With Higher Risk Of Total Mortality Scientific Studies 15
M Higher Fructose Intake Is Inversely Associated With Risk Of Nonalcoholic Fatty Liver Disease In Olde Scientific Studies 5
S BMIs Are Higher When Added Sugars Intake Is Less Than 10% The Ray Peat Forum Lounge 0
haidut Optimal Sodium Intake Is At Least 230% Higher Than RDA Sodium 84
R May need higher dose of glycine (10g)? Amino Acids 0
haidut Compared to meat eaters, vegans / vegetarian / pescatarians have higher risk of fractures Scientific Studies 15
Hans Outstanding stack for higher libido (and bigger balls) Articles & Scientific Studies 92
U What's Worse High Fat No Starch Or Low Fat Higher Starch? Diet 14
Mito 7-fold Higher COVID-19 Mortality In Vitamin D Deficient Subjects D 3
koreus Feel Warm But Temps Not Higher Than Usual Metabolism 3
B Crickets Fed Low Dose Aspirin Live 143% Longer, Have Longer Childhoods And Higher Metabolic Rates Scientific Studies 7
C Higher Carb To Protein Ratio Results In Higher Testosterone And Lower Cortisol In Men (1987) Scientific Studies 5
lvysaur Thymus Function: Higher In The Young/fat/female/Asian Scientific Studies 9
F Bald Men At Higher Risk Of Severe Covid-19 Viruses, Parasites, Fungus, Vaccines 9
E New Evidence That Higher Caffeine And Urate Levels Are Protective Against Parkinson's Disease Scientific Studies 2
Mito New Evidence That Higher Caffeine And Urate Levels Are Protective Against Parkinson’s Articles & Scientific Studies 0
Drareg Higher Tax Coming But You Can Afford It! Society 0
GorillaHead How Does AAS Use Lead To Higher Plaque Buildup ? Supplements, Pharmaceutical Drugs 2
yerrag Global Coronavirus Death Toll Could Be 60% Higher Than Reported Viruses, Parasites, Fungus, Vaccines 29
Drareg Global Coronavirus Death Toll Could Be 60% Higher Than Reported Viruses, Parasites, Fungus, Vaccines 6
P What Kind Of Carb Is Best When Eating Higher Saturated Fats Metabolism 3
cyclops Optimal Way To Dose Higher Amounts Of Supplemental Thyroid? Thyroid and Hormones 11
Y Should One Aim For Higher Than 98.6 F Under NDT (a Little Hyperthyroid)? Supplements, Pharmaceutical Drugs 3
Peatogenic Higher Blood Counts In PTSD Scientific Studies 0
N Maintaining A Higher Level Of Metabolism Health 4
cyclops Chickens Have A Higher Body Temp Than Cows? Diet 6
haidut Lowering DHT Synthesis Causes Severe Hypothyroidism, Despite Higher T Levels Scientific Studies 21
cyclops Temps Higher Without Thyroid? T3 11
Cameron Higher Dht And Testosterone And Less Toxic Trt Male Issues 149
AlphaCog Higher BMI May Be Better For Older Adults Scientific Studies 0
haidut Vegans And Vegetarians Have A Higher Risk Of Stroke Scientific Studies 6
Razvan How To Het Higher Waking Temperature? Ask For Help or Advice 3
B Higher Testosterone Levels Are Associated With Unfaithful Behavior In Men Ask For Help or Advice 41
P Fructose/Sucrose With Higher Protein Effects On Erection And Libido Male Issues 26
Hans Breakfast Skippers Might Be At Higher Risk Of Metabolic Inflexibility And Inflammation Scientific Studies 21
Mito Low Vitamin D At Birth Raises Risk Of Higher Blood Pressure In Kids D 0
P Higher Altitude - Greater Depression/Suicide Mental Issues 27
AlphaCog Higher Bone Mineral Density In Older Men With Diabetes And Impaired Fasting Glucose Scientific Studies 0
L Drinking Skim Milk Can Contribute To Having Higher-than-desirable Estrogen Levels Dairy 46
B Testosterone Linked To Higher Risk Of Heart Disease Heart, Heart Rate, Blood Pressure 6
W Nutritonal Optimization @ Higher Altitude Thyroid and Hormones 4
charlie High Energy Angstrom Foods, Electrical Universe, Higher Consciousness Health 148
Nicolas Noyola Sulfated Steroids Are Higher In Healthier People; Non-Sulfated Steroids Lower Blood Work, Labs 1
D Study Found Positive Correlation Between Iron And Total +free Testosterone, Higher T3, DHT Scientific Studies 20
T Higher Metabolism = Hair Loss Hair & Nails 84
alywest Higher Testosterone In Boys Reflective Of Lower Executive Function Hormones 7

Similar threads

Top