German University Researches B3 And Covid -Highly Peaty

[LeeLemonoil]

And also factor in ACE2 and Iron. Lots of peaty points here. Wait a bit until I link and translate.

 

[Drareg]

Tell that to general public and they think your a quack,even mentioning vitamin d and people think it’s strange and you might be quackish, even their doctor gets strange looks when mentioning said substances.

The mass subconscious masochism ,self loathing marathon running authoritarian personas require something more painful like aluminum phosphate to have any merit as a "cure"although calling it aluminum phosphate again makes it sound too vitaminy to be a "cure” ,all encompassing vague words like VACCINE are better.

 

[LeeLemonoil]

They started back in 2012 due to first SARS.
Noticed that in chronic inflammatory conditions the Tryptophan stela occurs. Meaning that Tryp does not get converted into Niacin but into excitatory and inflammation-promoting Mtabolites(as all Peaters know) This would alter the microbiome towards further inflamatory conditions.

ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. - PubMed - NCBI

ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation.

Abstract
Malnutrition affects up to one billion people in the world and is a major cause of mortality. In many cases, malnutrition is associated with diarrhoea and intestinal inflammation, further contributing to morbidity and death. The mechanisms by which unbalanced dietary nutrients affect intestinal homeostasis are largely unknown. Here we report that deficiency in murine angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (Ace2), which encodes a key regulatory enzyme of the renin-angiotensin system (RAS), results in highly increased susceptibility to intestinal inflammation induced by epithelial damage. The RAS is known to be involved in acute lung failure, cardiovascular functions and SARS infections. Mechanistically, ACE2 has a RAS-independent function, regulating intestinal amino acid homeostasis, expression of antimicrobial peptides, and the ecology of the gut microbiome. Transplantation of the altered microbiota from Ace2 mutant mice into germ-free wild-type hosts was able to transmit the increased propensity to develop severe colitis. ACE2-dependent changes in epithelial immunity and the gut microbiota can be directly regulated by the dietary amino acid tryptophan. Our results identify ACE2 as a key regulator of dietary amino acid homeostasis, innate immunity, gut microbial ecology, and transmissible susceptibility to colitis. These results provide a molecular explanation for how amino acid malnutrition can cause intestinal inflammation and diarrhoea.


Now in 2020 the german researchers from 2012 ju started a trial with Vitamin B3 and Covid-Patients:

UKSH startet bundesweite Ernährungsstudie zur Verbesserung des Verlaufs von COVID-19 (german)

COVit Studie (German)

Verhindert Vitamin B3 schwere COVID-19-Verläufe? (German)


The researchers were inteviewd her by Spiegel, I translate the good bits
Kieler Ernährungsstudie: Vitamin B3 bei Corona? - DER SPIEGEL - Wissenschaft

"We assume a B3 and/or Silicon defiency becuase of the inflamamtory processes caused by Covid, not due to a nutritional defiency in general. Our immunity reaches back to very early evolutionary patterns. Researches think that with many primitive organisms they alter their surfaces in - case of bacterial pathogens attack - in a way that they no longer "offer" nutrients that these bacteria would take in to replicate. Vitamins and Trace Elements. We have inherited this mechanism even though it hurts the organism in the long run

We call that "selective empoverishment" - In chronic inflammatory conditions the body for example breaks down Tryptophan into inflammatory metabolites.
Often you also see Anemia in chronic inflammation becuase Iron is figurativel thrown away by the body. You will handle infection poorer without adeqaute iron but we somehow have this reaction in our genetic cod


These are the meatiest pasages. I don't know if everything is correct what he sais but given that we discussed Anemia, ACE2 and stuff here before, this is an interesting trial.

Can we hope that we will see some of the basic rationale come back into medicine because of such an extraordinary situation like a worldwide pandemic? See the Losratan-Trials, the IV Vitamin C, now B3.
@haidut posted threads about mainstream medicine turning back to proven mechanisms because their muti-billion stuf doesnt work.

@Ella - this trial should be interesting to you

@Amazoniac @Terma

 

[LeeLemonoil]

He also thankfully makes clear that Typtophan supplementation is not advised since that can worsen the condition. That we would see that day.

 

[milkboi]

Tell that to general public and they think your a quack,even mentioning vitamin d and people think it’s strange and you might be quackish, even their doctor gets strange looks when mentioning said substances.

The mass subconscious masochism ,self loathing marathon running authoritarian personas require something more painful like aluminum phosphate to have any merit as a "cure"although calling it aluminum phosphate again makes it sound too vitaminy to be a "cure” ,all encompassing vague words like VACCINE are better.

Haha well said

 

[Motif]

Why not a b-complex?

 

[yerrag]

Is The World About To Panic Hoard Nicotine Products After France's Promising Coronavirus Study?

 

[Drareg]

Just to confuse the public even more and induce hyper hysteria WHO will in a matter of words recommend smoking for prevention of severe acute respiratory syndromes......

Will the deaths now correlate with non smokers being more susceptible to covid19?

 

[Drareg]

They started back in 2012 due to first SARS.
Noticed that in chronic inflammatory conditions the Tryptophan stela occurs. Meaning that Tryp does not get converted into Niacin but into excitatory and inflammation-promoting Mtabolites(as all Peaters know) This would alter the microbiome towards further inflamatory conditions.

ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. - PubMed - NCBI

ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation.

Abstract
Malnutrition affects up to one billion people in the world and is a major cause of mortality. In many cases, malnutrition is associated with diarrhoea and intestinal inflammation, further contributing to morbidity and death. The mechanisms by which unbalanced dietary nutrients affect intestinal homeostasis are largely unknown. Here we report that deficiency in murine angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (Ace2), which encodes a key regulatory enzyme of the renin-angiotensin system (RAS), results in highly increased susceptibility to intestinal inflammation induced by epithelial damage. The RAS is known to be involved in acute lung failure, cardiovascular functions and SARS infections. Mechanistically, ACE2 has a RAS-independent function, regulating intestinal amino acid homeostasis, expression of antimicrobial peptides, and the ecology of the gut microbiome. Transplantation of the altered microbiota from Ace2 mutant mice into germ-free wild-type hosts was able to transmit the increased propensity to develop severe colitis. ACE2-dependent changes in epithelial immunity and the gut microbiota can be directly regulated by the dietary amino acid tryptophan. Our results identify ACE2 as a key regulator of dietary amino acid homeostasis, innate immunity, gut microbial ecology, and transmissible susceptibility to colitis. These results provide a molecular explanation for how amino acid malnutrition can cause intestinal inflammation and diarrhoea.


Now in 2020 the german researchers from 2012 ju started a trial with Vitamin B3 and Covid-Patients:

UKSH startet bundesweite Ernährungsstudie zur Verbesserung des Verlaufs von COVID-19 (german)

COVit Studie (German)

Verhindert Vitamin B3 schwere COVID-19-Verläufe? (German)


The researchers were inteviewd her by Spiegel, I translate the good bits
Kieler Ernährungsstudie: Vitamin B3 bei Corona? - DER SPIEGEL - Wissenschaft

"We assume a B3 and/or Silicon defiency becuase of the inflamamtory processes caused by Covid, not due to a nutritional defiency in general. Our immunity reaches back to very early evolutionary patterns. Researches think that with many primitive organisms they alter their surfaces in - case of bacterial pathogens attack - in a way that they no longer "offer" nutrients that these bacteria would take in to replicate. Vitamins and Trace Elements. We have inherited this mechanism even though it hurts the organism in the long run

We call that "selective empoverishment" - In chronic inflammatory conditions the body for example breaks down Tryptophan into inflammatory metabolites.
Often you also see Anemia in chronic inflammation becuase Iron is figurativel thrown away by the body. You will handle infection poorer without adeqaute iron but we somehow have this reaction in our genetic cod


These are the meatiest pasages. I don't know if everything is correct what he sais but given that we discussed Anemia, ACE2 and stuff here before, this is an interesting trial.

Can we hope that we will see some of the basic rationale come back into medicine because of such an extraordinary situation like a worldwide pandemic? See the Losratan-Trials, the IV Vitamin C, now B3.
@haidut posted threads about mainstream medicine turning back to proven mechanisms because their muti-billion stuf doesnt work.

@Ella - this trial should be interesting to you

@Amazoniac @Terma

Is it niacin or niacinamide form they are using?

 

[TheSir]

Is it niacin or niacinamide form they are using?

They mention nicotinamide, B3 and niacin in the study, but no niacinamide.
ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation

 

[milkboi]

They mention nicotinamide, B3 and niacin in the study, but no niacinamide.
ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation

Nicotinamide = niacinamide

 

[Motif]

How much of it?

 

[Terma]

Thanks, I plan to take B3 for reasons alluded in Diokine's thread (but probably not the mechanism I emphasized - doesn't seem to apply in these dosages, didn't get back to it) but especially a minimum to prevent fibrosis. It's so generic you can probably link it to anything including the other explanations (even niacin for phospholipids, maybe even) until someone validates the most contributing mechanisms.

 

[RealNeat]

What would be a good everyday dose?

 

[haidut]

Often you also see Anemia in chronic inflammation becuase Iron is figurativel thrown away by the body.

Thanks. Just want to point out that the so-called "anemia in chronic inflammation" is not an actual anemia. I think they are referring to what in the US is called "anemia of chronic disease", and yes, it is related to chronic inflammation.
Anemia of Chronic Disease - Hematology and Oncology - Merck Manuals Professional Edition

But the key point here is that it is not actually an anemia but iron overload instead! Serum iron is often low but ferritin is high so the cells are overloaded with iron. It is thought that the body is trying to sequester iron from the blood to limit the inflammatory response. Hence the high ferritin and high iron content of liver, and other tissues. As such, this condition is NOT treatable by iron supplementation (unlike regular iron-deficiency anemia) but rather by iron chelation / depletion. They allude to this iron overload by saying the "Iron is figurativel thrown away by the body". So, aspirin, vitamin E, tetracycline antibiotics, milk, etc should all help as they tend to lower ferritin and thus iron stores.

 

[Drareg]

Thanks. Just want to point out that the so-called "anemia in chronic inflammation" is not an actual anemia. I think they are referring to what in the US is called "anemia of chronic disease", and yes, it is related to chronic inflammation.
Anemia of Chronic Disease - Hematology and Oncology - Merck Manuals Professional Edition

But the key point here is that it is not actually an anemia but iron overload instead! Serum iron is often low but ferritin is high so the cells are overloaded with iron. It is thought that the body is trying to sequester iron from the blood to limit the inflammatory response. Hence the high ferritin and high iron content of liver, and other tissues. As such, this condition is NOT treatable by iron supplementation (unlike regular iron-deficiency anemia) but rather by iron chelation / depletion. They allude to this iron overload by saying the "Iron is figurativel thrown away by the body". So, aspirin, vitamin E, tetracycline antibiotics, milk, etc should all help as they tend to lower ferritin and thus iron stores.

Similar to Alzheimer’s where blood iron shows up low as the disease progresses, it’s getting stored in the brain.

 

[Drareg]

They mention nicotinamide, B3 and niacin in the study, but no niacinamide.
ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation

As mentioned they are the same,nicotine similar.
It’s going to be interesting to run a correlation between moderate smokers and covid19 infection/deaths.

 

[haidut]

Similar to Alzheimer’s where blood iron shows up low as the disease progresses, it’s getting stored in the brain.

Not just Alzheimer's - this "anemia" of chronic disease (ACD) is also seen in cancer, "autoimmune" conditions (especially IBD), Lyme disease, etc. Basically, supporting Peat's point that iron overload is at the root of many chronic diseases.
Endotoxin And Iron Finally Recognized As Potential Causes Of Many Diseases

I think that since iron synergizes greatly with endotoxin to promote inflammation, the sequestering of iron seen in ACD is basically a defense/adaptive reaction of the organism to endotoxin excess. It corroborates the many published cases studies of antibiotics relieving ACD even if they have no known iron-chelation properties.
And of course, it implicates endotoxin as perhaps the main mechanism through which this coronavirus causes damage. Truly, not much different than the flu
The "Flu" May Be Simply A Sign/Symptom Of Elevated Endotoxin

 

[LeeLemonoil]

Thanks. I admit I haven’t followed the iron and endotoxin interplay much. I don’t quite understand too. Why does the organism removes iron from blood (blood cells?) into other cells? How would Iron remaining in blood interact with endotoxins and increase inflammatio?

Sorry for asking, I’m sure Haidut has explained that all before in detail in the respective threads

 

[LeeLemonoil]

I have his reread the protocol of standard intensive care in Germany for Covid-patients. As early as 1.3. they said that Short terms of cortisone shots should be applied with patients that no longer show active herds of virus or bacteria - to prevent fibrosis of the lungs.
Isn’t that what Niacinamide would help do, maybe in place of cortisone - prevent fibrosis

“The inflammatory factors that can promote cell growth can, with just slight variation, deplete cellular energy to the extent that the cells die from the energetic cost of the repair process, or mutate from defective repairs. Niacinamide can have an “anti-inflammatory” function, preventing death from multiple organ failure, by interrupting the reactions to nitric oxide and peroxynitrile“