Excess nicotinamide increases plasma serotonin and histamine levels

[Hgreen56]

Excess nicotinamide increases plasma serotonin and histamine levels - PubMed

Methylation, a methyl group-consuming reaction, plays a key role in the degradation (i.e., inactivation) of monoamine neurotransmitters, including catecholamines, serotonin and histamine. Without labile methyl groups, the methylation-mediated degradation cannot take place. Although high niacin...

pubmed.ncbi.nlm.nih.gov

 

[Belsazar]

After an
overnight fasting, urine was collected and quantitated
1 h before, and 1, 2, 3, 4 and 5 h after oral loading with
100 mg nicotinamide (Lisheng Pharma, Tianjin, China).

The subjects had to fast overnight, it has been noticed in the forum that you need to be well-fed especially with carbohydrates otherwise it can cause a stress reaction. It would be interesting to know how their tested markers behave in combination with carbohydrates.

For example, an increase in nicotinamide
intake can lead to an increase in urinary excretion of
5-hydroxyindoleacetic acid, a metabolite of serotonin [10] ,
suggesting an increase in tryptophan degradation
through tryptophan-serotonin pathway (i.e., an increase
in serotonin synthesis). Moreover, nicotinamide may
affect methylation-mediated serotonin degradation by
competing for methyl groups. Therefore, high nicotinamide
intake may increase serotonin levels by a mechanism
of increased synthesis and decreased degradation.

Interesting, hasn't Peat said that Plasma Serotonin is not a good Serotonin marker? What about Plasma Histamine?

 

[Mito]

That study was posted on the forum already.

100mg Niacinamide Increase Plasma Serotonin And Histamine

Excess nicotinamide increases plasma serotonin and histamine levels.

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