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@Astolfo
This idea might be interesting to you because you took a glucocorticoid and fluoxetine - a 5-HT2c antagonist - at the same time. It might have left you with upregulated 5-HT2c after you went off it while simultaneously GR insensitivity makes it impossible for cortisol to lower your serotonin levels:
Chronic citalopram and fluoxetine treatments upregulate 5-HT2c receptors in the rat choroid plexus. - PubMed - NCBI
The changes in receptor characteristics were not observed consistently after the 68-hour withdrawal from fluoxetine
Here is another aspect you can tie into that loop and into PTSD: the Dynorphin/KOR system is probably evolutionarily important because it helps organisms learn from mistakes and avoid future ones. It may help avoid energetically costly bad decisions and especially detect futile attempts to defeat stressors.
I make a bet that the KOR system is involved in the wiring of dopamine and 5-HT receptors, because it's already known to ablate dopamine and serotonin levels, but I'm not sure about the details.
KOR activation seems to be a failure "result" response following a period of stressful serotonin activation: 5HT receptors stimulated on threats release cortisol and stimulate CRH, which releases dynorphin, which stimulates KOR and lowers both dopamine and serotonin (disclaimer: may depend on brain area). It seems to be what signals a failure in an attempt to deal with a stressor or achieve something. In other words, KOR is normally the thing that stops the stress loop, because it has the power to restrain both catecholamines and serotonin. It allows you to stop so you can try something else later. It helps implement persistence. In nature, many predators fail the large majority of their hunts, but they learn from it and try again ad infinitum. This system could have evolved from such situations. KOR might be the "fishing" receptor. Not a lot of dopamine in fishing. Think about how incredibly persistent predators must be in nature in order to survive - sometimes it's mind-boggling. This is why we have things like KOR that we needed but make us feel like crap.
Its curious property is that you can benefit from both agonism for fear extinction and from antagonism to increase dopamine (as well as for upregulation).