Triiodothyronine (T3) enhances lifespan/ protects vs. ox-stress via activation of Klotho in C. elegans

[LeeLemonoil]

Triiodothyronine (T3) enhances lifespan and protects against oxidative stress via activation of Klotho in Caenorhabditis elegans - Biogerontology

Age predisposes individuals to significant diseases, and the biological processes contributing to aging are currently under intense investigation. Klotho is an anti-aging protein with multifaceted roles and is an essential component of the endocrine fibroblast growth factor. In Caenorhabditis...

link.springer.com

• Research Article
• Published: 13 April 2021

Triiodothyronine (T3) enhances lifespan and protects against oxidative stress via activation of Klotho in Caenorhabditis elegans​

Biogerontology (2021

 

[LLight]

Interesting since these seem to imply the opposite:

Downregulation of Klotho expression by dehydration - PubMed

Klotho, a transmembrane protein, protease, and hormone mainly expressed in renal tissue counteracts aging. Overexpression of Klotho substantially prolongs the life span. Klotho deficiency leads to excessive formation of 1,25(OH)(2)D(3), growth deficit, accelerated aging, and early death. Aging...

pubmed.ncbi.nlm.nih.gov

Water sensor ppk28 modulates Drosophila lifespan and physiology through AKH signaling

Sensory inputs are known to control aging. The underlying circuitry through which these cues are integrated into regulatory physiological outputs, however, remains largely unknown. Here, we use the taste sensory system of the fruit fly Drosophila melanogaster to detail one such circuit...

www.pnas.org

Detoxification-related gene expression accompanies anhydrobiosis in the foliar nematode (Aphelenchoides fragariae)

The foliar nematode (Aphelenchoides fragariae) is a quarantined pest that infects a broad range of herbaceous and woody plants. Previous work has demonstrated its remarkable ability to survive rapid and extreme desiccation, although the specific molecular ...

www.ncbi.nlm.nih.gov

Reminds me the experience on the rats, which seemed to extend the maximal lifespan quite significantly.

Also, vitamin K is an agonist to the SXR/PXR receptor which is involved in detoxification.

 

[Mauritio]

So androgens and T3 boost klotho .

But does klotho also boost androgens and T3 ?