Beefcake
Member
- Joined
- Apr 13, 2019
- Messages
- 290
Stumbled across two interesting studies regarding allopregnanolone.
Allopregnanolone and puberty: modulatory effect on glutamate and GABA release and expression of 3α-hydroxysteroid oxidoreductase in the hypothalamus ... - PubMed - NCBI
These results suggest an important physiological function of allopregnanolone in the hypothalamus of the P rat where it might be involved in the 'fine tuning' of neurosecretory functions related to the biology of reproduction
Allopregnanolone induces LHRH and glutamate release through NMDA receptor modulation. - PubMed - NCBI
These results suggest an important physiologic function of allopregnanolone on the regulation of neuroendocrine function in female adult rats. Not only appears to be involved in enhancing LHRH release through modulation of NMDA receptors but also in the release of glutamate which is critical in the control of LHRH release.
This would mean that you could possibly cure low hormone output or weak hypothalamus function by boosting allopreg. Haiduts 5a-dhp and also pure pregnenolone seems to be a good place to start.
I’m interested more in how the body decides that now its time for puberty and how it decides to stop it? Do we know that it even stops? Or is it just a gradual decline in health after? Anyone got the answer as to how the body knows its in its teens?
All I know from googling this is that at a certain age your body starts making more LHRH. Well why would not allopreg be the initiator of this? Allopregnenolone could be responsible for the start of puberty? How does allopreg get increased?
Allopregnanolone and puberty: modulatory effect on glutamate and GABA release and expression of 3α-hydroxysteroid oxidoreductase in the hypothalamus ... - PubMed - NCBI
These results suggest an important physiological function of allopregnanolone in the hypothalamus of the P rat where it might be involved in the 'fine tuning' of neurosecretory functions related to the biology of reproduction
Allopregnanolone induces LHRH and glutamate release through NMDA receptor modulation. - PubMed - NCBI
These results suggest an important physiologic function of allopregnanolone on the regulation of neuroendocrine function in female adult rats. Not only appears to be involved in enhancing LHRH release through modulation of NMDA receptors but also in the release of glutamate which is critical in the control of LHRH release.
This would mean that you could possibly cure low hormone output or weak hypothalamus function by boosting allopreg. Haiduts 5a-dhp and also pure pregnenolone seems to be a good place to start.
I’m interested more in how the body decides that now its time for puberty and how it decides to stop it? Do we know that it even stops? Or is it just a gradual decline in health after? Anyone got the answer as to how the body knows its in its teens?
All I know from googling this is that at a certain age your body starts making more LHRH. Well why would not allopreg be the initiator of this? Allopregnenolone could be responsible for the start of puberty? How does allopreg get increased?