lifespan

  1. F

    Calorie Restriction In Peat Thinking [Life Extension]

    I just read this: http://www.economist.com/news/briefing/21704788-fight-cheat-death-hotting-up-adding-ages It explores life extension through calorie restriction. Peating seems to involve a lot more calories than normal Explanation?
  2. tonto

    "Unsaturated Fats Linked To Longer Healthier Life" - Harvard Gazette

    I haven't read the JAMA article referenced, but wondering what people think of this... Unsaturated fats linked to longer, healthier life Consuming greater amounts of unsaturated fats is associated with lower mortality, according to a study from Harvard T.H. Chan School of Public Health. In a...
    • tonto
    • Thread
    • lifespan longevity pufa
    • Replies: 48
    • Forum: Cholesterol
  3. P

    NAD⁺ Repletion Improves Mitochondrial And Stem Cell Function And Enhances Life Span In Mice

    NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice. - PubMed - NCBI Adult stem cells (SCs) are essential for tissue maintenance and regeneration yet are susceptible to senescence during aging. We demonstrate the importance of the amount of the oxidized...
  4. P

    Hypoxia As A Therapy For Mitochondrial Disease

    Hypoxia as a therapy for mitochondrial disease. - PubMed - NCBI Defects in the mitochondrial respiratory chain (RC) underlie a spectrum of human conditions, ranging from devastating inborn errors of metabolism to aging. We performed a genome-wide Cas9-mediated screen to identify factors that...
  5. haidut

    Sun Avoidance Decreases Lifespan

    Ray said once that avoiding the sun is very carcinogenic, which is quite contrary to what the various skin cancer experts would like you to believe. This study seems to confirm Ray's point, at least when it comes to females. Sunbather Paradox: Sun Woshippers Live Longer Than Those Who Avoid The...
  6. haidut

    Possible Explanation Of The Obesity Paradox

    I recently posted a thread on the being overweight with a BMI or 27 associated with lower mortality than being lean. Taller People Have Higher Mortality From Cancer This study claims to have found a possible explanation, and it has to with the fact that the ability to accumulate fat is an...
    • haidut
    • Thread
    • accumulation fat increased lifespan obesity paradox overweight reduction stress tag triacylglycerol
    • Replies: 0
    • Forum: Scientific Studies
  7. haidut

    Taller People Have Higher Mortality From Cancer

    I am sure this will ignite a firestorm again, but that is not my intention. Last week, I posted this study that claimed overweight people have lower mortality. People With The Lowest Overall Mortality Are Overweight That relationship has been claimed to be explainable by a proportion of skinny...
  8. haidut

    HDAC Inhibitors Affect Every Function Of The Cell And May Extend Lifespan

    The use of HDAC inhibitors such as valproic acid or various butyrate salts for cancer treatment has been studied experimentally for decades. Until now, it was assumed that the process of histone acetylation and deacetylation affected mostly the processes associated with cell division and...
    • haidut
    • Thread
    • acetylation aging cell function hdac hdac inhibitor histone lifespan niacinamide sirtuins survival vital
    • Replies: 12
    • Forum: Scientific Studies
  9. haidut

    Tough / Rough Childhood Shortens Lifespan By Up To 75%

    The study was done with baboons, but given how closely related they are to humans I think the results are a lot more pertinent than rat stress studies, which btw have been shown to translate pretty well to humans. A wild baboon usually lives for up to 45 years. So, the fact that some of the...
    • haidut
    • Thread
    • adversity childhood healthspan lifespan rough short tough
    • Replies: 32
    • Forum: Scientific Studies
  10. E

    Uncoupling Mice Brain Mitochondria Extends Lifespan

    This study seems puzzling in light of what RP claims is one of the best indicators of general health. I'm trying to figure out how this study doesn't contradict RP but have not found an explanation yet. Anyone else? Cool mice live longer : Nature News
  11. haidut

    Aspirin Pro-Drug From Willow Bark Extends Yeast Lifespan By Almost 400%

    I don't know if the active ingredient in willow bark that is responsible for this lifespan extension is salicylic acid, but it is very likely given the increase in metabolism of yeast given the willow bark extract. It is worth noting that willow bark extract was the most potent of all 10,000+...
    • haidut
    • Thread
    • acid aspirin bark extension lifespan salicylic willow
    • Replies: 13
    • Forum: Scientific Studies
  12. haidut

    The Physics Of Life (active Matter)

    Ray has written many times about the spurious mind-matter duality dominating science for centuries. The same principles that govern "inanimate" matter also apply to living systems. Hans Selye and Albert Szent-Györgyi built up on work done by Russian scientists in the early 1900s and proposed...
    • haidut
    • Thread
    • active matter article lifespan
    • Replies: 39
    • Forum: Science
  13. haidut

    Intelligence And Lifespan Are Correlated

    Ray has written about this in several of his articles, and has mentioned it in a few of his interviews. One obvious explanation of the connection is that intelligent people make better lifestyle choices and this leads to better health and longer life. However, the more likely explanation is...
  14. haidut

    Blocking Serotonin Extends Lifespan By 40%, Triples Youthspan

    The amazing effects of blocking serotonin just keep piling on. I posted a study some time ago showing that anti-serotonin drugs like mianserin and cyproheptadine extended lifespan by 30%-40% while serotonergic drugs like SSRI shortened lifespan by as much as 80%! viewtopic.php?f=178&t=6451 Now...
    • haidut
    • Thread
    • lifespan pharmaceutical drugs serotonin ssri
    • Replies: 21
    • Forum: Articles
  15. charlie

    Frequent Blood Donors Live Longer Than Less Frequent Donors

    More at link: http://sciencenordic.com/frequent-blood ... ive-longer
    • charlie
    • Thread
    • article blood donation health lifespan
    • Replies: 1
    • Forum: Health
  16. haidut

    Pregnenolone Increases Maximum Lifespan By 60% (animal Model)

    The study also hints that other hormones from the same cluster may have similar effect. It is also worth noting that the study used a technique to stimulate increased endogenous pregnenolone synthesis rather than use external supplementation. http://www.ncbi.nlm.nih.gov/pubmed/17266678
  17. haidut

    DMSO extends lifespan

    The study was done in worms but I still think it has merit. DMSO was not as effective as caffeine in creasing maximum lifespan, but still did a pretty good job compared to other substances like caffeine. In fact, DMSO extends lifespan by the same amount as the anti-serotonin drugs I posted about...
  18. Y

    Study Says Coffee/caffeine Shortens Lifespan By Shortening Telomeres

    Hi all, Please refer to the study below. It basically says that coffee, decreases telomeres which are end parts of DNA. Which increases cellular death chance. And telomeres are associated with poor health, and shorter lifespan. alcohol on other hand, increased it. NOT saying i believe this...
  19. haidut

    Serotonin Antagonists Extend Lifespan, SSRI Dramatically Shorten It

    This study looked specifically at mianserin, but did compare it to other drugs (including cyproheptadine). The conclusion was that mianserin and cyproheptadine extend lifespan by up to 30% by mimicking the effects of caloric restriction. Interestingly, mianserin increases appetite just like...
  20. S

    Saturated Lipids Probably Survive Your Whole Life In The Eye

    No turnover in lens lipids for the entire human lifespan
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