Mar 18, 2013
USA / Europe
I recently posted a thread on the being overweight with a BMI or 27 associated with lower mortality than being lean.
Taller People Have Higher Mortality From Cancer

This study claims to have found a possible explanation, and it has to with the fact that the ability to accumulate fat is an insulator against stress. When the cell is not allowed to accumulate fat in the presence of stress, it dies earlier. So, I suppose this is yet another piece of evidence that supports the view of being fat as an indication of stress levels rather than overall health.

'Obesity Paradox': New Study Reveals Obesity Paradox In Yeast Cells

"...A new study from Michigan State University researchers further supports the "obesity paradox," showing that cells with higher fat contents outlive lean cells. The results have implications for larger organisms, including humans, and support the current data showing that overweight people have the lowest-all cause mortality rates, while fit people have higher mortality rates that are similar to those seen in people labeled as slightly obese. "The obesity paradox baffles scientists across numerous disciplines," Min-Hao Kuo, lead author of the study, said in a press release. "But when it comes to yeast, which is an excellent model for the studies of human aging, increasing the cellular content of triacylglycerol, or fat, extends the lifespan."

"...Kuo and his team first found a positive correlation between triacylglycerol (TAG) content, a form of fat found in all eukaryotes including animals and plants, and lifespan. Although scientists know that TAG gives organisms the ability to store excessive amounts of energy, which can provide insulation to many stressors, the mystery lies in how it is connected to lifespan."

"...The results showed that in both cases, blocking TAG breakdown and increasing its production led to fatter yeast cells and a prolonged lifespan, contrary to lean yeast cells which did not have the ability to synthesize TAG and died early. Additionally, forced TAG in a normal strain leads to its breakdown, which also leads to a decreased lifespan. Another interesting finding of the study is that the yeast cells with increased TAG did not suffer from any noticeable growth defects and showed normal mating and standard resistance to environmental stresses. Kuo believes that this sort of pro-longevity function is present in humans as well, although its connection to TAG has yet to be proven."
Similar threads
Thread starter Title Forum Replies Date
alywest Losartan As Anti-coagulant, Possible Explanation For Success In COVID Patients? Viruses, Parasites, Fungus, Vaccines 1
T Potassium Ascorbate With Ribose For Cancer (With Cell Level Explanation Inside) Possible Treatment Cancer 32
G Possible mold exposure - I need to sleep Ask For Help or Advice 10
Alex Jaramillo Possible testicular torsion Male Issues 2
C Is It Possible To Safely Raise My TSH? Ask For Help or Advice 6
Bogdar Low PTH, Low D, High Calcium - How Is It Possible? Blood Work, Labs 12
Starship Is It Possible To Keep Metabolism High And MTOR Low? Metabolism 2
JanP How To Stop Inflammation Of The Nerves As Quickly As Possible Ask For Help or Advice 3
M Thoughts On PSSD And Possible Treatment Male Issues 4
Doludolu Teeth Enamel Worn Out. Why? Remineralization Possible? Oral Health 76
L Is Growing Taller As An Adult Possible? Male Issues 27
Velve921 What Are Things You Can Do Now That You Didn’t Believe Would Be Possible? Metabolism 1
L Possible To Improve Hearing? Eyes, Ears, Nose and Headaches/Migraines 5
P Thyroid Woes, Possible Viral Infection/desperate For Guidance Ask For Help or Advice 6
L Possible Skin Cancer Help :/ Skin 5
ScurveDream DHEA Or Pregnenolone To Combat Possible Caffeine-induced Stress? Ask For Help or Advice 8
D Possible Constipation Male Issues 9
R Is It Possible To Regenerate Herniated Spinal Disc ? Ask For Help or Advice 6
D Possible Ways To Lower Serotonin In Young Children Autism 10
D Is It Possible For Gynecomastia Go Away IF You Got It After Puberty? Male Issues 20
ddjd Buying Steroids From China: Any Possible Way To Verify Quality? Ask For Help or Advice 14
J Is It Possible To Grow Bone Structure At The Age Of 21? Ask For Help or Advice 14
G Lab Test Shows HIGH Trans Fats But I Consume Zero Trans Fats. How Is This Possible? Blood Work, Labs 2
F A Possible Solution To COVID-19 Viruses, Parasites, Fungus, Vaccines 3
dfspcc20 Possible Viral Symptoms? Maybe COVID-19? Symptoms, Causes 12
Mito SARS-COV-2 Infection: The Possible Preventative Role Of Methylene Blue Scientific Studies 38
Laurence Possible Inhibitors Of ACE2, The Receptor Of 2019-nCoV Scientific Studies 3
Mito Possible Biological Explanations For Kids’ Escape From COVID-19 Articles & Scientific Studies 0
N PCOS & Tumor On Thyroid - Possible Treatments Female Issues 6
JanP Possible To Overtax The Pancreas / Liver / Digestive System By Too Much Sugar? Ask For Help or Advice 4
T Is It Possible To Heal Hypothyroidism Without Medicine? Thyroid and Hormones 35
C Is It Possible To Supplement Female Cat Hormones After Spaying? Animals 1
R Is It Possible To Restore DHEAs Levels? Ask For Help or Advice 19
UltraSuperior How Do I Get Ripped As Fast As Possible? Weight 12
L Possible (but Painful) Way To Get Around The Accumulating Birth Control In Water Toxins, Detoxification 2
J Need To Boost Metabolism High As Possible For A Test Metabolism 19
Elchapchapchapo Tinnitus - Infared LLLT - Possible Cure Eyes, Ears, Nose and Headaches/Migraines 2
Watubi Branch Retinal Vein Occlusion. Is Reversal Possible The Ray Peat Way? Eyes, Ears, Nose and Headaches/Migraines 1
T Is It Possible To Test CD14? Labs 1
G Thyroid Synthetic T3 - Water Solution - Is It Possible ? Supplements, Pharmaceutical Drugs 2
R Possible Reasons For High Potassium On A Blood Test? Ask For Help or Advice 1
LuMonty Possible Aldi Mexican Coke Sale Soda (Mexican Coke, Pepsi, etc.) 6
C Possible Nonclassic Congenital Adrenal Hyperplasia ? Male Issues 12
JanP Diet Completely Free Of Salt? Possible To Survive / Thrive? Ask For Help or Advice 43
A Orange Light Plus β-Lapachone Derivative As Possible Skin Cancer Treatment Scientific Studies 5
HealthisWealth Is It Possible To Digest Vegetable And No Leafy Stool? Vegetables, Grains, Legumes, Fiber 0
bboone Possible Iron Overload Supplements, Pharmaceutical Drugs 31
Amazoniac Getting Plenty Of Magnesium Without Supplements: Tough But Possible Magnesium 52
R Possible Goiter? Natural Dessicated Thyroid 3
M White Moons On Nails - Possible Iron Overload? Health 13

Similar threads