Temperature alone is not a marker of metabolism. It's things like oxygen consumption, heat production that are used to determine metabolic rate. Heat production has not been measured in the experiment, but the the body temperature which is maintained through vasodilation or vasoconstriction in the skin and sweating, regulated by nerves and hormones.it seems by definition that metabolism of the body considered as a whole had to be slowed down (or their temps wouldn't have dropped).
Lower temperatures increase mitochondrial biogenesis.
Mitochondrial biogenesis is an adaptive process, a reaction to stress or stimuli. Exposure to cold has been shown to stimulate mitochondrial biogenesis in brown fat to tolerate the cold better (in other words: keep up the body temperature).So the higher body temperatures created by a RP approved healthy thyroid fueled metabolism actually simultaneously inhibits mitochondrial biogenesis because of the resultant higher body temps? Now I'm really confused!
Yes, and more is not always better. Efficiency rules first and foremost. Incidentally, stressful cardio creates mitochondria and angiogenesis.Mitochondrial biogenesis is an adaptive process, a reaction to stress or stimuli. Exposure to cold has been shown to stimulate mitochondrial biogenesis in brown fat to tolerate the cold better (in other words: keep up the body temperature).
So the higher body temperatures created by a RP approved healthy thyroid fueled metabolism actually simultaneously inhibits mitochondrial biogenesis because of the resultant higher body temps? Now I'm really confused!
It does not look puzzling to me. The problem with this article is there is no description of
Hi ejalrp, to answer this, Thyroid, and many other pro metabolic aspects stimulate mitochondria biogenesis:
“Environmental enrichment, learning, high altitude, and thyroid hormone promote the formation of new mitochondria, and stimulate stem cell proliferation.” [RP]
As you probably know, the body is unimaginaby complex, and every "marker" must be analyzed in relation to the whole. Context, they call it. High temp/high pulse don't necessarily imply good metabolism, with bad metabolism you can be suffering from pathological "good"temp/pulse
"The basal metabolic rate, which is mainly governed by thyroid, roughly corresponds to the average body temperature. However, in hypothyroidism, there is an adaptive increase in the activity of the sympathetic nervous system, producing more adrenalin, which helps to maintain body temperature by causing vasoconstriction in the skin."
"While the early morning body temperature will sometimes be low in hypothyroidism, I have found many exceptions to this. In protein deficiency, sodium deficiency, in menopause with flushing symptoms, and in both phases of the manic depression cycle, and in some schizophrenics, the morning temperature is high, corresponding to very high levels of adrenalin and cortisol. Taking the temperature before and after breakfast will show a reduction of temperature, the opposite of what occurs in simple hypothyroidism, because raising the blood sugar permits the adrenalin and cortisol to fall."
"In old people, who lose heat easily during the day, their extreme increase in the compensatory nervous and hormonal adrenalin activity causes their night-time heat regulation (vasoconstriction in the extremities) to rise to normal."
(My comment: This probably is comparable to the old mice in the study, therefore the uncoupling calmed their nervous system via an improvement in metabolism, thus revealing the real core temp?)
Thyroid, insomnia, and the insanities: Commonalities in disease
And an example that I love a lot to show that pathological increase in temp can be detrimental:
"Since a sudden increase in temperature will release increased amounts of the pro-inflammatory fats, things should be changed gradually. Increased salt is thermogenic, but increased magnesium is protective against hyperthermia, so increased magnesium (epsom salts baths, for example, coffee, fruits, some vegetables and meats) would be helpful."
"Since aspirin lowers temperature, is antiinflammatory, in some situations antiestrogenic, and is a powerful antioxidant, it is likely that it would alleviate symptoms and prevent progression of MS, as it does in other degenerative diseases. "
"Temperature regulation apparently involves some nerve cells that sense temperature very accurately, and change their activity accordingly. Water has a remarkably high heat capacity, meaning that it takes a relatively large amount of heat to change its temperature. The "disappearing heat" is being consumed by structural changes in the water. Proteins have the same sort of structural complexity as water, and together they can make effective temperature transducers, "thermometers." (Other substances tend to undergo major structural changes only as they melt or vaporize. The famous "liquid crystals" have a few distinct structural phases, but cytoplasm is like a very subtle liquid crystal.) The "thermostat cells" are actually responding to a degree of internal structure, not to the temperature in the abstract. [my comment: this implies that the goal is to offer the body the temperature that is cellular "structure" needs to not melt, not too much, not to little. In the mice study, this old animals probably weren't regulating temp very well and the uncoupling of the brain brought the temp it to match the real structure] So things that change their internal structure will modify their temperature "set-point." "
"If this is the situation in the nerves in MS, it explains the strange behavior, in which warming the nerve reduces its function. The implication is that internal structure (and energy) must be restored to the nerves. In experiments that I have described in previous newsletters, increasing sodium, ATP, carbon dioxide, and progesterone, and increasing the ratio of magnesium to calcium, have been found to increase cellular energy and structure. The thyroid hormone is ultimately responsible for maintaining cells' energy and structure, and responsiveness, but if it is increased suddenly without allowing all the other factors to adjust, it will raise the temperature too suddenly. It needn't take a long time, but all the factors have to be present at the same time."
"Serotonin, melatonin, estrogen, and polyunsaturated fats all tend to lower body temperature. Since estrogen and the unsaturated fats are cellular excitants, the actual decrease in body temperature helps to offset their excitatory effects."
Multiple sclerosis, protein, fats, and progesterone
I find this topic fascinating :)
(Mr. @haidut et. al. invited to comment)
I also think it is fascinating. Body temperature by itself can be very misleading. For instance, people with serotonin syndrome have very high fever and we would certainly not count them as hypermetabolic. High histamine will create very high surface temps but core temp will not change or even be lower. In those people, aspirin will lower temperature, so I think this is the context Peat is writing about. In normal folks, higher doses of aspirin raises core body temp. Just ask anybody with rheumatoid arthritis who is self-medicating with high dose aspirin - i.e. they often go out shirtless in the winter. I have tested it myself - 3g single dose aspirin gets me (and most of the people I know) sweating profusely and ear temps rise to 100 degrees. Caffeine does the same.
So, I think, like the other posts pointed out, there are a few extra factors that need to be measured. These include oxygen consumption, especially in the brain, lactate, urine output (as a biomarker of metabolism), blood CO2 levels, etc.
This is more like the opposite of ice baths, sensing a high temperature could be turning off adrenaline and brown fat, etc. it's basically similar to the reset from fixlowbodytemp.com
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