caffeine

  1. haidut

    Caffeine protects against breast cancer by lowering estrogen

    Given the studies I posted on caffeine increasing testosterone, DHT, pregnenolone and progesterone this study is not very surprising but it helps to see that caffeine is directly anti-estrogenic in human tissues. http://clincancerres.aacrjournals.org/content/21/8/1877 "...Moderate (2–4...
  2. haidut

    Caffeine Has Androgenic Effects On The Testes

    I posted several studies on low-ish doses of caffeine raising testosterone and DHT. The mechanism was increase in 5-AR activity. This study claims that substances that raise levels of cAMP have andromimetic properties on the testes. Of all natural substances caffeine is by far the most powerful...
  3. Velve921

    Good Source Of Caffeine

    Does anyone have any good sources of supplemental caffeine?
  4. Bluebell

    Caffeine Pills - Do we get used to them?

    I am taking a small amount of caffeine in addition to coffee. I always take it with lots of protein, sugar, and food, so I don't get jitters. I feel good from the caffeine, it is just an extra 50mg twice a day right now but I might increase it. I was thinking that for non-Peating people, they...
  5. K

    Caffeine Increases Autophagy

    I think this is a very interesting article: http://www.anti-agingfirewalls.com/2013 ... s-aging-2/ It talks about possible health benefits of caffeine by increasing autophagy. I've heard many good things about autophagy, but not really from Ray Peat. I wonder what you guys think about this. A...
    • Kasper
    • Thread
    • article autophagy caffeine supplemental
    • Replies: 3
    • Forum: Articles
  6. haidut

    Cytochrome C is a metabolic target of caffeine

    It seems that adenosine antagonism is the mechanism of action so other adenosine antagonists may be metabolically beneficial as well. http://www.ncbi.nlm.nih.gov/pubmed/18583456 "...Using mass spectroscopy, we found that Cox7c, a nuclear-encoded subunit of the mitochondrial enzyme cytochrome...
  7. haidut

    Caffeine stimulates electron flow, may uncouple respiration

    The drug used was a caffeine salt but in the body it is metabolized to caffeine and sodium benzoate, so the effects are pretty much like those of caffeine. The concentration used (6microM - 60microM) corresponds to in vivo human dose of 30mg-300mg. http://www.ncbi.nlm.nih.gov/pubmed/7456349...
  8. haidut

    Caffeine restores cytochrome C damaged by sepsis

    Animal study and it only looked at effects of sepsis on the heart, however I do not see why the results would not apply to other organs damaged by similar methods like endotoxin (which can be considered a milder version of sepsis). Human dose would be equal to one cup of coffee or about...
  9. haidut

    Caffeine As A Potential Cancer Treatment

    Yet another study that revisits the "novel" idea that improving cellular oxygenation can lead to a viable cancer treatment. In summary, high adenosine levels result in low oxygen levels inside the cell and that apparently prevents the immune system from recognizing and "killing" the cancer...
  10. haidut

    Coffee Consumption Protects DNA Integrity

    The study looked at coffee (750ml daily, which is about 3 cups), not caffeine, even though I suspect the benefits are mostly due to caffeine and the iron-reducing effects of chlorogenic acid. http://www.ncbi.nlm.nih.gov/pubmed/24740588
  11. P

    Caffeine Alters Proliferation Of Neuronal Precursors In The Adult Hippocampus

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743873/ Neurogenesis continues through adulthood in the hippocampus and olfactory bulb of mammals. Adult neurogenesis has been implicated in learning and memory, and linked with depression. Hippocampal neurogenesis is increased in response to a...
  12. haidut

    Topical Absorption Of Caffeine, Aspirin And Niacinamide

    Another study, which looked at absorption of these Peat-approved substances through human skin. http://www.nature.com/jid/journal/v54/n ... 18185a.pdf Niacinamide absorption in acetone (the solvent used in the study) was only about 10%, however as per another human study I posted some time...
  13. haidut

    Topical Caffeine As Sunscreen

    In support of the recently launched SolBan, here is an article in the popular press about caffeine's sunscreen effects and protection against skin cancer when applied topically. http://www.theguardian.com/science/2011 ... kin-cancer
    • haidut
    • Thread
    • body care caffeine sunscreen topical
    • Replies: 1
    • Forum: Body Care
  14. haidut

    Coffee Lowers Risk Of Endometrial Cancer

    The scientists say they don't know exactly how coffee lowers the risk but think that lower estrogen in coffee drinkers may be the mechanism. http://www.webmd.com/cancer/news/201502 ... ancer-risk "...The researchers also can't say for sure why coffee may lower the cancer risk. However, one...
    • haidut
    • Thread
    • abstract caffeine cancer endometrial health
    • Replies: 0
    • Forum: Cancer
  15. Peata

    Caffeine Dosing

    Is it best to take smaller doses throughout the day -- or -- one or two larger doses earlier in the day?
    • Peata
    • Thread
    • caffeine supplemental
    • Replies: 7
    • Forum: Caffeine
  16. haidut

    Low Dose Caffeine Effective For Premature Ejaculation

    Don't think many Peatarians struggle with this problem, but I thought that it may be an interesting study since the people who have this problem are generally told that there are no effective treatments except SSRI. The SSRI don't really treat anything but rather remove the desire for sex...
  17. haidut

    Coffee (caffeine) protects against melanoma

    The study supports once again Peat's statements, and even though it looked at coffee usage, it is likely that caffeine is the protective substance since decaffeinated coffee did not have much effect. The mechanism of action may be caffeine's effects of increasing levels of cAMP, which leads to...
  18. P

    caffeine can reduce respiratory quotient

    maybe if not taken with lot of carbs/sugar http://www.ncbi.nlm.nih.gov/pubmed/16076989 http://www.ncbi.nlm.nih.gov/pubmed/10584049 http://www.ncbi.nlm.nih.gov/pubmed/19176733 http://www.ncbi.nlm.nih.gov/pubmed/16366740 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2621121
  19. N

    Caffeine May Be More Evil Than You Think!

    Ray Peat is glorious and all but the one thing that I disagree with him on, is his promotion of caffeine. I have read Stephen Cherniske's "Caffeine Blues". It goes into great detail about how bad caffeine is. It's full of science. Now, Ray Peat is all about reducing stress - yet he recommends...
  20. haidut

    Caffeine Acts Like Supplemental Thyroid - It Suppresses TSH / GH

    Based on Ray's writings about caffeine being a surrogate for thyroid hormone, this study showed that caffeine suppresses both TSH and growth hormone (GH). Ingestion of Cynoplus or other equivalent product containing both T4 and T3 has been shown to have the same effects. The effective human...
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