One time I took 2 drops of Progestene and I got so euphoric, maybe I got that feeling 2-3 times actually. That was like 2 years ago. Since then I never felt anything using it again, despite taking long breaks. Weird.
I've had the same effect with pregnenolone. I could take 10mg of the stuff and feel a euphoric effect. Now I can take 200mg and nothing happens, despite extended breaks.