I got some heated comment after my first show with Danny. The comments were about PUFA increasing cortisol synthesis. I was told that there is no study showing such connection. Well, here is one. As you can see high PUFA diet (70% PUFA) increases expression of 11b-HSD1, which is the enzyme responsible for cortisol synthesis. Also, high PUFA diet had the same effects as aging but the effects were stronger in the high PUFA group.
http://www.ncbi.nlm.nih.gov/pubmed/22033707
"...Hsd11b1 mRNA levels in the 12C, 6F and 12F groups were 170, 114 and 218% of that in the 6C group, respectively, with a significant increase in the 12F group. Hence, the liver mRNA levels of Hsd11b1 and Rbp4 were increased by aging, and increased further by a high-fat diet. This suggests that a high-fat diet accelerates aging, and that hyperinsulinemia and lipid accumulation in the liver are promoted by increased expression of these genes."
"...Overall, our results show that intake of a high-fat diet accelerated aging, increased the expression level of Hsd11b1, increased insulin secretion, and promoted lipid accumulation in the liver of SAMP10 mice. This suggests that repression of Hsd11b1 mRNA level is important for prevention of diseases such as hyperinsulinemia and fatty liver caused by a high-fat diet and aging. Since the expression of these genes increases with aging, a long-term approach to repression of the genes is required, and this might be achieved through control of food intake."
Two of the most powerful supplements for suppressing 11b-HSD are DHEA and retinol (vitamin A). Animal studies show that DHEA as little as 5mg can inhibit 11b-HSD and dose of about 20,000 IU retinol can do the same.
http://www.ncbi.nlm.nih.gov/pubmed/22033707
"...Hsd11b1 mRNA levels in the 12C, 6F and 12F groups were 170, 114 and 218% of that in the 6C group, respectively, with a significant increase in the 12F group. Hence, the liver mRNA levels of Hsd11b1 and Rbp4 were increased by aging, and increased further by a high-fat diet. This suggests that a high-fat diet accelerates aging, and that hyperinsulinemia and lipid accumulation in the liver are promoted by increased expression of these genes."
"...Overall, our results show that intake of a high-fat diet accelerated aging, increased the expression level of Hsd11b1, increased insulin secretion, and promoted lipid accumulation in the liver of SAMP10 mice. This suggests that repression of Hsd11b1 mRNA level is important for prevention of diseases such as hyperinsulinemia and fatty liver caused by a high-fat diet and aging. Since the expression of these genes increases with aging, a long-term approach to repression of the genes is required, and this might be achieved through control of food intake."
Two of the most powerful supplements for suppressing 11b-HSD are DHEA and retinol (vitamin A). Animal studies show that DHEA as little as 5mg can inhibit 11b-HSD and dose of about 20,000 IU retinol can do the same.