Amazoniac
Member
http://ndt.oxfordjournals.org/content/e ... l.pdf+html - worth reading before
http://www.ncbi.nlm.nih.gov/pubmed/1564572
"We hypothesize that inadequacy of dietary protein may result in lowered antioxidative enzyme activities and enhanced tissue lipid peroxidation. These effects of a low protein diet may not be significant at low polyunsaturated fat intake but may be manifested and aggravated when dietary polyunsaturated fat level is gradually increased."
"In the normal protein diet groups, TBARS in RBC were not significantly different between the high soybean oil (N20) and the low soybean oil (N5) groups (Table 3). However, in rats fed the low protein diet, TBARS in RBC increased significantly with the increase of dietary soybean oil level."
"The results indicated that even at normal protein intake, high polyunsaturated fat intake may increase TBARS in plasma, but not in RBC. The L15E group had significantly lower plasma TBARS than in the L15 group, suggesting that supplementation of vitamin E effectively reduced plasma TBARS, but not RBC TBARS, in rats fed low protein-high soybean oil diet."
"Unlike the SOD activity, RBC catalase activity was lowered either by high soybean oil or low protein diet alone."
"Supplementation of vitamin E to the L15 diet significantly reversed the reduced RBC SOD and catalase activities to a level comparable to those of the L2 and L5 [% of soybean oil, L for low-protein] groups."
"Supplementation of vitamin E to the LI5 diet significantly reduced the elevated TEARS in liver and heart to a level comparable to those of the N20 group." So, even in a diet deficient in antioxidants that depend on protein, supplementing vit E greatly attenuates the damage induced by PUFA.
"These data suggest that rats fed a low protein diet might be more susceptible to peroxidative tissue damage under the challenge of oxidative stress such as a high soybean oil intake."
"Protein malnutrition, resulting from low quality or quantity of dietary protein, not only retards animal growth but also changes the metabolism via modification of the hormonal profile. As a result, turnover of some enzyme protein could be specifically altered. For example, the liver microsomal detoxification enzyme activities and inducibility were shown to be lowered by low protein (29, 30) and low quality protein (31) diets. Iritani et al. (32) reported decreased lipogenic enzyme activities including G6PDH in rats fed soybean protein or gluten diets compared with rats fed casein or fish protein diets."
"Although rats fed low protein diets consumed less food (grams per rats) than the N5 group, the food intake/body weight of these groups was, in fact, higher than that of rats fed the normal protein diet. It seems that inadequacy of dietary protein per se rather than lowered food intake is associated with higher susceptibility to tissue lipid peroxidation. Chipalkatti et al. (33) demonstrated that when mice were fed a normal diet, but their food intake was restricted to 50% of the ad libitum-diet group, lower heart lipofusin content and lower liver lipid peroxidation were observed."
http://www.ncbi.nlm.nih.gov/pubmed/1564572
"We hypothesize that inadequacy of dietary protein may result in lowered antioxidative enzyme activities and enhanced tissue lipid peroxidation. These effects of a low protein diet may not be significant at low polyunsaturated fat intake but may be manifested and aggravated when dietary polyunsaturated fat level is gradually increased."
"In the normal protein diet groups, TBARS in RBC were not significantly different between the high soybean oil (N20) and the low soybean oil (N5) groups (Table 3). However, in rats fed the low protein diet, TBARS in RBC increased significantly with the increase of dietary soybean oil level."
"The results indicated that even at normal protein intake, high polyunsaturated fat intake may increase TBARS in plasma, but not in RBC. The L15E group had significantly lower plasma TBARS than in the L15 group, suggesting that supplementation of vitamin E effectively reduced plasma TBARS, but not RBC TBARS, in rats fed low protein-high soybean oil diet."
"Unlike the SOD activity, RBC catalase activity was lowered either by high soybean oil or low protein diet alone."
"Supplementation of vitamin E to the L15 diet significantly reversed the reduced RBC SOD and catalase activities to a level comparable to those of the L2 and L5 [% of soybean oil, L for low-protein] groups."
"Supplementation of vitamin E to the LI5 diet significantly reduced the elevated TEARS in liver and heart to a level comparable to those of the N20 group." So, even in a diet deficient in antioxidants that depend on protein, supplementing vit E greatly attenuates the damage induced by PUFA.
"These data suggest that rats fed a low protein diet might be more susceptible to peroxidative tissue damage under the challenge of oxidative stress such as a high soybean oil intake."
"Protein malnutrition, resulting from low quality or quantity of dietary protein, not only retards animal growth but also changes the metabolism via modification of the hormonal profile. As a result, turnover of some enzyme protein could be specifically altered. For example, the liver microsomal detoxification enzyme activities and inducibility were shown to be lowered by low protein (29, 30) and low quality protein (31) diets. Iritani et al. (32) reported decreased lipogenic enzyme activities including G6PDH in rats fed soybean protein or gluten diets compared with rats fed casein or fish protein diets."
"Although rats fed low protein diets consumed less food (grams per rats) than the N5 group, the food intake/body weight of these groups was, in fact, higher than that of rats fed the normal protein diet. It seems that inadequacy of dietary protein per se rather than lowered food intake is associated with higher susceptibility to tissue lipid peroxidation. Chipalkatti et al. (33) demonstrated that when mice were fed a normal diet, but their food intake was restricted to 50% of the ad libitum-diet group, lower heart lipofusin content and lower liver lipid peroxidation were observed."
