Xylitol Prevents Growth Stunting Effect Of Endotoxin Injection

[Quelsatron]

(in chickens)
Effect of dietary concentration of xylitol on growth in male broiler chicks during immunological stress - ScienceDirect

"Two experiments were conducted to determine the effect of dietary xylitol concentration on growth performance, plasma (alpha1 acid glycoprotein (AGP), nitrite, and Fe concentration in male broiler chicks during immunological stress. Ten-day-old chicks were fed a corn-soybean diet containing 15% glucose and 6% xylitol or 15% xylitol with identical metabolizable energy and crude protein content for 12 d in Experiment 1. In Experiment 2, 12-d-old chicks were fed either the 15% glucose or 6% xylitol diet for 7 d. During the final 6 d of each experiment, half of the birds fed each diet were injected intraperitoneally with Escherichia coli lipopolysaccharide (LPS; 0127:B8) on Days 1, 3, and 5 and with Sephadex-G50 superfine on Days 2 and 4 to stimulate the immune system. The xylitol diets partially prevented reductions in body weight gain, feed intake, and feed efficiency caused by LPS and Sephadex injections, but the glucose diet did not. The injections of LPS and Sephadex increased plasma AGP and nitrite concentrations. Plasma AGP concentration on Days 2 and 6 in chicks fed the xylitol diets did not differ from that of chicks fed the glucose diet in both experiments. Nitric oxide production estimated by plasma nitrite concentration following immunological stress did not differ due to dietary treatments in Experiment 2. The LPS and Sephadex resulted in decreased plasma Fe concentration on Day 6 in Experiment 1 in chicks fed glucose but not xylitol. These results indicate that a beneficial effect of dietary xylitol on growth is obtained with 6% xylitol given to chicks 1 d before stimulating the immune system."
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I've read that xylitol can have an antibacterial effect locally and in the intestine, but it's interesting to see that it seems to also mitigate some damage by the endotoxin itself. It doesn't seem to be the fattening metabolic effect of things like corn that Ray has talked about and everyone here is familiar with, because they also made note of the food intake and feed efficiency, and so from table 2:

Feed intake before/after LPS of glucose diet: 437 / 389 (g/five days)
Feed efficiency before/after LPS of glucose diet: 0.68 / 0.64 (g gained/g eaten)
Feed intake before/after LPS of 6% xylitol diet: 440 /408 (g/five days)
Feed efficiency before/after LPS of 6% xylitol diet: 0.69 / 0.69 (g gained/g eaten)
Feed intake before/after LPS of 15% xylitol diet: 410 / 380 (g/five days)
Feed efficiency before/after LPS of 15% xylitol diet: 0.72 / 0.69 (g gained/g eaten)
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and as you can see the xylitol feed efficiency is basically the same as with glucose

 

[Grapelander]

Maybe take this with aspirin if we are in a situation where we are forced to stimulate our immune system. Good find.

 

[Quelsatron]

Maybe take this with aspirin if we are in a situation where we are forced to stimulate our immune system. Good find.

I mean, I would assume that it would help with chronic gut endotoxin exposure (ensposure?) as well