Therapeutic Role Of PPAR–α For Increase Allopregnanolone

Discussion in 'Hormones' started by alex mas, Jul 30, 2019.

  1. alex mas

    alex mas Member

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    Hi people,
    I became involved in several (very recent) studies to find a solution to my PTSD. I found these very recent studies that show that the activation of the PPAR-α receptor stimulates the endogenous synthesis of allopregnanolone. The nice thing is that there are already drugs on the market, in addition to the natural endocannabinoids, which activate PPAR-α. for example fibrates. from the study it emerges that they could have a new role in the treatment of many mental disorders.
    @haidut what do you think about it? could fibrates help people with PTSD ?

    Emerging Therapeutic Role of PPAR–α in Cognition and Emotions
    Stimulation of Peroxisome Proliferator-Activated Receptor-α by N-Palmitoylethanolamine Engages Allopregnanolone Biosynthesis to Modulate Emotional ... - PubMed - NCBI
     
  2. ecstatichamster

    ecstatichamster Member

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  3. LeeLemonoil

    LeeLemonoil Member

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    Retinol is a PPR-a agonist
     
  4. OP
    alex mas

    alex mas Member

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    still not tried either. only small dose of pregnenolone. and immune system's dysregulation is secure involved in maintaining the ptsd but i think minocycline is dangerous for microbiome. it may help but for short time but not restore neurosteroides homosteasy. Fibrates should be a safe drugs used since many years and they can be taken for long term. secure i will look in big dose of pregnanolone. what dosage do you mean ?
     
  5. ecstatichamster

    ecstatichamster Member

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    50mg of minocycline a day is probably safe over the long term.

    For pregnenolone, 100mg - 300mg per day is what I was thinking.
     
  6. High_Prob

    High_Prob Member

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    How about Palmitoylethanolamine (PEA) (which alex mas referenced above), which is readily available as a supplement...
     
  7. OP
    alex mas

    alex mas Member

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    I tried but 0 result...PEA is endocannabinoid broken by FAAH enzyme. In chronic stress FAAH become hyperactive and degrades much faster endocannabinoids like PEA and anandamide. I Think i got weak result with PEA for this. FAAH inhbitor would like the light for PTSD. But for Now these drug are under devolpment.
     
  8. Sativa

    Sativa Member

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    I copied this list of PPAR alpha activators from a selfhacked.com page. He advocates fish oils/pufas, but, just use your common sense and ray peats insight to clarify these suggestions:

     
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