Therapeutic Role Of PPAR–α For Increase Allopregnanolone

[alex mas]

Hi people,
I became involved in several (very recent) studies to find a solution to my PTSD. I found these very recent studies that show that the activation of the PPAR-α receptor stimulates the endogenous synthesis of allopregnanolone. The nice thing is that there are already drugs on the market, in addition to the natural endocannabinoids, which activate PPAR-α. for example fibrates. from the study it emerges that they could have a new role in the treatment of many mental disorders.
@haidut what do you think about it? could fibrates help people with PTSD ?

Emerging Therapeutic Role of PPAR–α in Cognition and Emotions
Stimulation of Peroxisome Proliferator-Activated Receptor-α by N-Palmitoylethanolamine Engages Allopregnanolone Biosynthesis to Modulate Emotional ... - PubMed - NCBI

 

[ecstatichamster]

Have you tried minocycline?
Early post-stressor intervention with minocycline, a second-generation tetracycline, attenuates post-traumatic stress response in an animal model o... - PubMed - NCBI

Have you tried high dose pregnenolone?

 

[LeeLemonoil]

Retinol is a PPR-a agonist

 

[alex mas]

Have you tried minocycline?
Early post-stressor intervention with minocycline, a second-generation tetracycline, attenuates post-traumatic stress response in an animal model o... - PubMed - NCBI

Have you tried high dose pregnenolone?

still not tried either. only small dose of pregnenolone. and immune system's dysregulation is secure involved in maintaining the ptsd but i think minocycline is dangerous for microbiome. it may help but for short time but not restore neurosteroides homosteasy. Fibrates should be a safe drugs used since many years and they can be taken for long term. secure i will look in big dose of pregnanolone. what dosage do you mean ?

 

[ecstatichamster]

still not tried either. only small dose of pregnenolone. and immune system's dysregulation is secure involved in maintaining the ptsd but i think minocycline is dangerous for microbiome. it may help but for short time but not restore neurosteroides homosteasy. Fibrates should be a safe drugs used since many years and they can be taken for long term. secure i will look in big dose of pregnanolone. what dosage do you mean ?

50mg of minocycline a day is probably safe over the long term.

For pregnenolone, 100mg - 300mg per day is what I was thinking.

 

[High_Prob]

How about Palmitoylethanolamine (PEA) (which alex mas referenced above), which is readily available as a supplement...

 

[alex mas]

How about Palmitoylethanolamine (PEA) (which alex mas referenced above), which is readily available as a supplement...

I tried but 0 result...PEA is endocannabinoid broken by FAAH enzyme. In chronic stress FAAH become hyperactive and degrades much faster endocannabinoids like PEA and anandamide. I Think i got weak result with PEA for this. FAAH inhbitor would like the light for PTSD. But for Now these drug are under devolpment.

 

[Sativa]

I copied this list of PPAR alpha activators from a selfhacked.com page. He advocates fish oils/pufas, but, just use your common sense and ray peats insight to clarify these suggestions:

• Pathways to activate PPAR alpha: SIRT1 [19], PGC-1a [20]
• Cold [21]
• Exercise [12]
• Sun/UVB (skin) [22]
• Fasting [23] – fasting increases SIRT1 via activation of PPAR-alpha in mice [24].
• DHEA [25]
• Zinc [26]
• R-Lipoic Acid [28]
• Hydroxytyrosol [29]
• Cinnamon [31]
• EGCG [32, 33]
• Bitter melon [34]
• Epimedium/Icariin [35]
• Nicotinamide Riboside – NAD+ helps activate both PPAR-alpha and SIRT1[24].
• Oregano – carvacrol [36], Biochanin A [30]
• Naringenin [38]
• PQQ [39]
• Palmitoylethanolamide (PEA) [40]
• Lion’s Mane [41]
• Leukotriene B4
• Gynostemma [42]
• Anandamide [43]