Theacrine

[High_Prob]

For anyone that has tried this substance, can you please post your experiences (positive and/or negative).

 

[dookie]

BUMP. Also interested in this. And if people have experience with other substances similar to caffeine, like pentoxyfilline or lisofylline

 

[golder]

Bump round 2, 2 years later.

 

[Experienced]

Bump round 2, 2 years later.

Bump

 

[matisvijs]

Should have a similar effect to caffeine, supposedly with less jitters (or that's what people report at least), with lower dosage needs. Never taken it myself though.

 

[Experienced]

Should have a similar effect to caffeine, supposedly with less jitters (or that's what people report at least), with lower dosage needs. Never taken it myself though.

Increase in adenosine receptors?

 

[matisvijs]

Increase in adenosine receptors?

Yes, as well as the dopaminergic action of caffeine, though you have to remember that increased receptor density usually means that it is an antagonist to the adenosine (which both caffeine and theacrine are):

Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine: Involvement of adenosine and dopamine receptors - ScienceDirect - dopamine agonist, adenosine antagonist
Redirecting - appears to have anti-inflammatory effects where caffeine doesn't

 

[Experienced]

So theacrine is adenosine antagonist?

 

[Experienced]

Yes, as well as the dopaminergic action of caffeine, though you have to remember that increased receptor density usually means that it is an antagonist to the adenosine (which both caffeine and theacrine are):

Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine: Involvement of adenosine and dopamine receptors - ScienceDirect - dopamine agonist, adenosine antagonist
Redirecting - appears to have anti-inflammatory effects where caffeine doesn't

 

[matisvijs]

So theacrine is adenosine antagonist?

Yeah, one of the net effects is adenosine antagonism.

 

[Experienced]

adenosine antagonism.

It's so hard to get my hands on Theacrine.

 

[matisvijs]

It's so hard to get my hands on Theacrine.

It's not that hard ime - here's one on Amazon, 60 capsules for under 20$: https://amzn.to/2XWr7mD
Also, most nootropics shops have it, if you don't want to buy this one.