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Reports suggest the therapeutic threshold for some people is above 35 grams.
Thank you. Based on what I've read, if you reach a therapeutic dose and stay at that level for a few days you can then move down to a much lower maintenance dose.You are going to take doses well above RDA (something like RDA times 1000) and will be in pharmacological territory.
Even if it works (until you stop taking it?), it probably won't be treating the root cause of your issue, which is probably not niacin deficiency based on your previous experiments.
Once again I stand to be corrected by your results and wish you to have good results and be able to heal
| niacin the real story filetype:pdf |
Niacin apparently heals a leaky blood-brain barrier. This is a theoretical explanation for why it could effect the brain so much in the beginning and then lose its potency.
OK.
www.medicalnewstoday.com
Assuming you survive your experiment with half cups of niacin.... Did you catch the part about liver failure in my post above? I'm not sure what you mean by "surface-scare".
He’s likely relying on the Hoffer book. I’m paraphrasing but in it he says that the elevated liver enzymes detected during niacin treatment indicates that the liver is merely active and is not reacting in a pathological manner.
Well, it's his body after all. He can take lots of niacin if he wants to.
Use coupon code DMITRYKATS for a discount at PureBulk.You are providing an excellent description of thiamine deficiency. Consider this possibility. Read about it. I'll provide links to information at the end of my post.
I had two siblings. Both developed schizophrenia when they were in their teens. My brother committed suicide 14 years ago at age 56. I was not as severely affected (the mental instability part) as they were but I've had my own problems. I've researched this a lot.
The trigger for the three of us was heavy metal poisoning; lead from the lead soldered plumbing pipes in the house we grew up in plus mercury amalgam fillings place when each of us were children. Heavy metal toxicity causes thiamine deficiency. Thiamine deficiency causes brain hypoxia. The heavy metal bonds to the thiamine molecules and either destroys them or makes them unavailable for the body to use. Thiamine deficiency causes the blood brain barrier to leak which allows undesirable molecules to get inside the brain.
The solution is thiamine supplementation. There are multiple choices of types and there's a lot of information on line about it.
here's some links for your consideration:
Depression, Anxiety, and the Chronically Hypoxic Brain - Hormones Matter
Abnormal thoughts, emotions and all forms of mental activity are produced by electrochemical reactions that are exaggerated by a mild degree of hypoxia or pseudo-hypoxia.www.hormonesmatter.com
Thiamine Testing:
Thiamine testing is really tricky; I gave up trying after my GP was unable to find a lab in the U.S. that does the accurate test. I'm relying on my response to it and what I've learned about it on line. I started with 300-350 mg of thiamine hcl, (available here) and experienced improvement within 45 minutes. But I'm not you. You'll just need to experiment with it. Another way to try it is to get some of the sublingual type. Here's some info about it. And here's a book about it.
It is a good idea to take some magnesium with thiamine; I use magnesium glycinate. I also take a little riboflavin (about 30mg 4Xday) plus a little niacinamide (90mg 4Xday).
Here's an article about thiamine testing:
Thiamine Deficiency Testing: Understanding the Labs - Hormones Matter
Understanding thiamine deficiency and the lab testing methods most appropriate for detecting abnormal thiamine chemistry.
Navigating Thiamine Supplements- Hormones Matter
Understanding the different forms of vitamin B1.
I chose to stick with thiamine hcl because I could not tolerate TTFD because my glutathione level was in the ditch due to heavy metal toxicity. Happily taking high dose thiamine hcl has normalized my glutathione level for the first time in many years. Although the amount needed (1 gram, 2Xday is my dose; it's based on body weight) is a large amount (due to poor absorption in the gut), the pure bulk powder is inexpensive. A little of it tastes as bad as a lot of it so it's just a matter of getting used to the taste. Always take it with plain water, never anything sweet, and space taking it at least 30 minutes away from consuming carbs (starch or sugar containing food).
Here are some sources for info about thiamine:
Dr. Costantini's website. He successfully treated thousands of Parkinson's Disease patients in Italy using thiamine hcl. I chose to follow his protocol because I tolerate thiamine hcl better than TTFD. Dr. Costantini's FAQ's are well worth the time to read. His patient before and after videos are illuminating and very short.
Dr. Derrick Lonsdale's articles. He is on the far side of 99 and although is in a wheel chair and assisted living, he still has his wits about him which is a great testament to TTFD.
Daphne Brian's book about thiamine and Parkinson's Disease; she found great success using a sublingual form of thiamine which I have tried and found that it does work. This website is based on Dr. Costantini's work with thiamine hcl.
Elliot Overton's youtube channel. Excellent videos and a great way to get started learning about thiamine. Elliot focuses mainly on TTFD thiamine but the information can be extrapolated over to the other types of thiamine for general understanding. He explains the pros and cons of the different types.
Elliot Overton's website. Excellent articles under Blog. Also links to his videos.
Thanks!
Thanks for posting this. I find it interesting that for all its powers, neither niacin, nor the other substances with which Hoffer supplemented, were able to prevent his appearance from aging.
Genetics and stress may be the key here. A farming life is a more evolutionarily-consistent environment and occupation, thus conferring a great psychological advantage compared to some city job, effecting health downstream of this. We know people who live in more rural areas tend to have less genetic mutations compared to city dwellers. And it may not be due to the difference in environment, necessarily. Additionally, you mentioned he was short. An individual's size and their longevity are inversely correlated. So the smaller an individual is, the more long-lived they will tend to be (according to the research).
