Serotonin Antagonists (1984)

[Koveras]

"The realisation that serotonin plays a role not only in the carcinoid syndrome but also in migraine, nociception, dumping syndrome, vascular disease and hypertension, has led to an enormous amount of activity in search of serotonin antagonists. Numerous such pharmacological agents have been identified but only few have found their way into clinical use. All of them are competitive serotonin inhibitors, in that they vie for the same receptor as the amine itself and are thus able to block its action as well as imitate its effects. By far the widest use of such inhibitors is in the prevention of migraine, where they have effectively eliminated the dread of an attack from the life of the majority of patients. Whilst useful in the control of diarrhea in patients with carcinoid and dumping syndromes, their role in these diseases is limited. However, the possible role of serotonin in hypertension and nociception opens new avenues in the use of existing serotonin antagonists and calls for the discovery of a new generation of such pharmacological agents for the control of these conditions."

http://onlinelibrary.wiley.com.sci-hub.io/doi/10.1111/j.1445-5994.1984.tb03802.x/abstract

 

[DaveFoster]

Kind of curious about psilocybin.

 

[Koveras]

Kind of curious about psilocybin.

Been meaning to get to this one....

Psychedelics

 

[DaveFoster]

Been meaning to get to this one....

Psychedelics

Very interesting; it would be good to know if psilocybin carries the same, more, or less risk for cardiac fibrosis than LSD.

 

[goodandevil]

Very interesting; it would be good to know if psilocybin carries the same, more, or less risk for cardiac fibrosis than LSD.

Presumably by the same mechanism as dopamine agonist fibrosis, unless it's an ergot alkaloid property vs dopamine agonist.

 

[BRMarshall]

Very interesting; it would be good to know if psilocybin carries the same, more, or less risk for cardiac fibrosis than LSD.

Did you ever get your answer to this?

 

[DaveFoster]

Did you ever get your answer to this?

I looked into it slightly, but the binding affinity for the 5-HT2B receptor would indicate the risk, as well as the dosage, blood levels and half life.

Why Chronic Microdosing Might Break Your Heart

While there has been very promising evidence of safety and effectiveness for psychedelics after a few acute macrodoses in clinical trials, the risks and benefits of chronic microdosing still remain

chacruna.net