Serotonin antagonists (could) prevent / treat osteoporosis

Discussion in 'Scientific Studies' started by haidut, Nov 7, 2013.

  1. haidut

    haidut Member

    Mar 18, 2013
    USA / Europe
    Not sure if Peat has mentioned this before, but I decided to post it anyway. The take of the story is that serotonin antagonists, and especially 5-HT3 antagonists like ondansetron would be very good treatment for osteoporosis.
    Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis. - PubMed - NCBI

    "...Osteoporosis is a disease of low bone mass most often caused by an increase in bone resorption that is not sufficiently compensated for by a corresponding increase in bone formation. As gut-derived serotonin (GDS) inhibits bone formation, we asked whether hampering its biosynthesis could treat osteoporosis through an anabolic mechanism (that is, by increasing bone formation). We synthesized and used LP533401, a small molecule inhibitor of tryptophan hydroxylase-1 (Tph-1), the initial enzyme in GDS biosynthesis. Oral administration of this small molecule once daily for up to six weeks acts prophylactically or therapeutically, in a dose-dependent manner, to treat osteoporosis in ovariectomized rodents because of an isolated increase in bone formation. These results provide a proof of principle that inhibiting GDS biosynthesis could become a new anabolic treatment for osteoporosis."