ecstatichamster
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- Joined
- Nov 21, 2015
- Messages
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That study is surely bunk. Saturated fats have been used successfully to treat liver disorders.
But it was an over feeding study.
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That study is surely bunk. Saturated fats have been used successfully to treat liver disorders.
From the study....“The SAT but not the other diets also increased markers of endotoxemia and upregulated genes related to gram-negative bacterial infection in adipose tissue. These changes could have contributed to SAT-induced lipolysis and de novo ceramide synthesis, because in mice, endotoxin induces both adipose tissue inflamation (11) and ceramide-dependent IR (10).”
This matches a post by @tyw:
“(2) The more double bonds in a fat, the LESS endotoxin gets into the serum. A PUFA like DHA will cause less endotoxin to be transferred into the bloodstream, as compared to a Saturated Fat like Coconut Oil. [paper (a)]”
Endotoxin And Fat Consumption
That might be true but it doesn’t change the result of the study with regard to saturated fat increasing liver triglycerides significantly more than unsaturated fat or carbohydrates (in the context of an energy excess i.e. overweight/overfed subjects).but that says endotoxin is the causal agent of the liver damage,
Remember this was an overfeeding study of overweight subjects with BMI’s around 32.Great -- now saturated fat is bad, and because I haven't hesitated to consume it over the past year, my fat-laden liver is now probably worse than ever? Or maybe this is just being posted to spur more contentious debate.
I think all this proves is:SFA - coconut oil, butter, and blue cheese
PUFA - olive oil, pesto, pecans, butter
Carbs - OJ, sugar sweetened beverage, candy
I think all this proves is:
a) butter is an SFA, not a PUFA
b) Olive oil is not nearly so bad as seed oils
c) pecans aren't nearly so bad as seed oils
d) pesto is made with . . . olive oil
And the whole moldy cheese thing already addressed.
What I am getting at is, butter is included in both.SAT - coconut oil, butter, and blue cheese (76% SFA/21% MUFA/3% PUFA)
UNSAT - olive oil, pesto, pecans, butter (57% MUFA/22% PUFA/21% SFA)
haha yes I felt guilty using it but I think it summarized the key issue which is too much fat for the body to store at one time. I think you are right that SFAs are protective when eaten in normal amounts but are unhealthy and even dangerous when eaten in excess.Wikipedia. Hmm. That's not a study. It's an article contrived of suspect observations and even more suspect conclusions. And again we have direct evidence to the contrary, SFA protects from liver damage.
For example:
Dietary saturated fatty acids: a novel treatment for alcoholic liver disease. - PubMed - NCBI
Virgin coconut oil reverses hepatic steatosis by restoring redox homeostasis and lipid metabolism in male Wistar rats. - PubMed - NCBI
That study I linked to has a number of studies in it that demonstrate exactly that. The only way you can isolate any effects of endotoxins is to run the experiment in vitro. Otherwise you could always say that the SFAs are allowing in endotoxins. I would also add that you are just assuming that it is the endotoxins causing all the damage in vivo. The endotoxin theory just doesnt hold up when liver cells are damaged exactly the same way whether in vivo or in vitro due to excess fatty acids."may enter deleterious pathways leading to cell dysfunction" Hmm.
Olive oil contains Omega-9 which Ray has already written about with regard to anti-inflammatory mead acid. Again, I've yet to see the study showing damage in a human from SFA in absence of LPS; they don't exist.
You asked for human studies; the no bacteria study you propose would be unethical."The only way you can isolate any effects of endotoxins is to run the experiment in vitro."
You can do experiments in animals with no bacteria. This has been done numerous times.