Oxidized vitamin c and diabetes

[seppl]

First I found this connection:

Ascorbic acid and diabetes mellitus​

Ascorbic acid and diabetes mellitus - PubMed

Dehydroascorbic acid, the oxidized form of vitamin C, causes diabetes when injected into animals and has been reported to be present in increased amounts in the blood of patients with diabetes mellitus and even in prediabetics. One of the earliest changes in diabetes mellitus is...

pubmed.ncbi.nlm.nih.gov

then this:

Dehydroascorbic acid-induced endoplasmic reticulum stress and leptin resistance in neuronal cells​

Dehydroascorbic acid-induced endoplasmic reticulum stress and leptin resistance in neuronal cells - PubMed

Due to its anti-obesity effects, an adipocyte-derived hormone, leptin, has become important for the treatment of obesity. However, most obese subjects are in a state of leptin resistance, and endoplasmic reticulum (ER) stress is suggested to be involved in the pathophysiology of leptin...

pubmed.ncbi.nlm.nih.gov

could it be, that a simple antioxidant in many foods, added for preservation, is causing this?

I know, if you want diabetic animals, you have to do this:

Studies of streptozotocin-induced insulitis and diabetes.​

Studies of streptozotocin-induced insulitis and diabetes - PubMed

Multiple small injections of streptozotocin produce a delayed, progressive increase in plasma glucose in mice within 5-6 days after the injections, in association with pronounced insulitis and induction of type C viruses within beta cells. Multiple subdiabetogenic doses of streptozotocin in rats...

pubmed.ncbi.nlm.nih.gov

from there you can easily make a connection to:

The effects of repeated exposure to sub-toxic doses of plecomacrolide antibiotics on the endocrine pancreas​

The effects of repeated exposure to sub-toxic doses of plecomacrolide antibiotics on the endocrine pancreas - PubMed

The plecomacrolide vacuolar ATPase inhibitors bafilomycin and concanamycin contaminate tuberous vegetables and damage pancreatic islets in mice. The consequences of repeated exposure of adult mice to sub-toxic doses of bafilomycin A1 or concanamycin A was examined by injection of the...

pubmed.ncbi.nlm.nih.gov

so, toxins on potatoes and beets like carrots can induce diabetes, if you dont remove the fauling parts of the food.
At home everybody is doing so, i can see the the rotten parts and throw away. But what about industry? Where tons of potatoes are processed?
Fries, wedges, potatoe starch?

i think I had a study with table-sugar from beets, where the mycotoxin was already found.

​

Dietary microbial toxins and type 1 diabetes​

Dietary microbial toxins and type 1 diabetes - PubMed

Toxins may promote type 1 diabetes by modifying or damaging the beta cell causing release of autoantigens. Streptomyces is a common soil bacterium that produces many toxic compounds. Some Streptomyces can infect vegetables, raising the possibility of dietary exposure to toxins. We aimed to...

pubmed.ncbi.nlm.nih.gov

could it be so?
am I overlooking something?
(you can clearly see, english is not my native language

 

[Rinse & rePeat]

First I found this connection:

Ascorbic acid and diabetes mellitus​

Ascorbic acid and diabetes mellitus - PubMed

Dehydroascorbic acid, the oxidized form of vitamin C, causes diabetes when injected into animals and has been reported to be present in increased amounts in the blood of patients with diabetes mellitus and even in prediabetics. One of the earliest changes in diabetes mellitus is...

pubmed.ncbi.nlm.nih.gov

then this:

Dehydroascorbic acid-induced endoplasmic reticulum stress and leptin resistance in neuronal cells​

Dehydroascorbic acid-induced endoplasmic reticulum stress and leptin resistance in neuronal cells - PubMed

Due to its anti-obesity effects, an adipocyte-derived hormone, leptin, has become important for the treatment of obesity. However, most obese subjects are in a state of leptin resistance, and endoplasmic reticulum (ER) stress is suggested to be involved in the pathophysiology of leptin...

pubmed.ncbi.nlm.nih.gov

could it be, that a simple antioxidant in many foods, added for preservation, is causing this?

I know, if you want diabetic animals, you have to do this:

Studies of streptozotocin-induced insulitis and diabetes.​

Studies of streptozotocin-induced insulitis and diabetes - PubMed

Multiple small injections of streptozotocin produce a delayed, progressive increase in plasma glucose in mice within 5-6 days after the injections, in association with pronounced insulitis and induction of type C viruses within beta cells. Multiple subdiabetogenic doses of streptozotocin in rats...

pubmed.ncbi.nlm.nih.gov

from there you can easily make a connection to:

The effects of repeated exposure to sub-toxic doses of plecomacrolide antibiotics on the endocrine pancreas​

The effects of repeated exposure to sub-toxic doses of plecomacrolide antibiotics on the endocrine pancreas - PubMed

The plecomacrolide vacuolar ATPase inhibitors bafilomycin and concanamycin contaminate tuberous vegetables and damage pancreatic islets in mice. The consequences of repeated exposure of adult mice to sub-toxic doses of bafilomycin A1 or concanamycin A was examined by injection of the...

pubmed.ncbi.nlm.nih.gov

so, toxins on potatoes and beets like carrots can induce diabetes, if you dont remove the fauling parts of the food.
At home everybody is doing so, i can see the the rotten parts and throw away. But what about industry? Where tons of potatoes are processed?
Fries, wedges, potatoe starch?

i think I had a study with table-sugar from beets, where the mycotoxin was already found.

​

Dietary microbial toxins and type 1 diabetes​

Dietary microbial toxins and type 1 diabetes - PubMed

Toxins may promote type 1 diabetes by modifying or damaging the beta cell causing release of autoantigens. Streptomyces is a common soil bacterium that produces many toxic compounds. Some Streptomyces can infect vegetables, raising the possibility of dietary exposure to toxins. We aimed to...

pubmed.ncbi.nlm.nih.gov

could it be so?
am I overlooking something?
(you can clearly see, english is not my native language

It seems like a reasonable answer, though not the only culprit. It lines up with junk food, fast food and restaurant food altogether being a major cause of diabetes. Diabetes was not a big thing long ago and they ate a lot of potatoes, but they also took the time to prepare foods properly. Ray Peat always did say that vitamin C supplements are problematic, especially citric acid. Ascorbic acid CAN remedy some situations with short term use, but has repercussions with longterm use, and maybe diabetes is one?

 

[seppl]

Yesterday a doku in germany shows the production of citric acid from aspergillus niger. Perhaps the next suspect for a contamination of food?
I try a pubmed-search for asp.niger and diabetes and find that:

Microbes Associated with Freshly Prepared Juices of Citrus and Carrots - PubMed

Fruit juices are popular drinks as they contain antioxidants, vitamins, and minerals that are essential for human being and play important role in the prevention of heart diseases, cancer, and diabetes. They contain essential nutrients which support the growth of acid tolerant bacteria, yeasts...

pubmed.ncbi.nlm.nih.gov

Solution? only selfmade orange juice?

and the many other industry products with citric acid for conservation?

a safe nutrition will need more knowledge and more work and more money.
more than normal people will spend.
i am a teacher and nutritionist, most of the pupils have no interest for such things.

not the best prospects