Long-term treatment with calcium-alpha-ketoglutarate corrects secondary hyperparathyroidism

[Lokzo]

Long-term treatment with calcium-alpha-ketoglutarate corrects secondary hyperparathyroidism​

E Zimmermann, S Wassmer, V Steudle

• PMID: 8676818

Abstract​

Calcium-alpha-ketoglutarate (Ca-ket) is known as a highly effective phosphate (P) binder in hemodialysis (HD) patients. In addition, alpha-ketoglutarate has been shown to improve metabolic alterations. We investigated the effect of long-term P-binding therapy with Ca-ket to determine whether P accumulation is the main reason of secondary hyperparathyroidism (HPT) in HD patients or not. Ca-ket was prescribed to 14 HD patients as a soluble preparation in a mean dosage of 4.5 g/day (0.975 g elemental Ca) for a period of 36 months. Serum P continuously dropped from prestudy 2.6 +/- 0.1 (mean +/- SEM) to 1.9 +/- 0.07 mmol/l (p < 0.001), whereas serum Ca increased from 2.2 +/- 0.1 to 2.47 +/- 0.08 mmol/l (p < 0.05). Thus, Ca/P ratio in serum converted significantly from 0.91 +/- 0.02 (prestudy) to 1.28 +/- 0.01 (p < 0.001). Intact parathyroid hormone (iPTH) continuously normalized in all patients from 29 +/- 5 to 8 +/- 2 pmol/l (p < 0.001). The present data show that long-term treatment with Ca-ket normalizes secondary HPT by simultaneously P binding and correcting Ca/P ratio in serum without vitamin D treatment.

 

[Mauritio]

Serum P continuously dropped from prestudy 2.6 +/- 0.1 (mean +/- SEM) to 1.9 +/- 0.07 mmol/l (p < 0.001), whereas serum Ca increased from 2.2 +/- 0.1 to 2.47 +/- 0.08 mmol/l (p < 0.05). Thus, Ca/P ratio in serum converted significantly from 0.91 +/- 0.02 (prestudy) to 1.28 +/- 0.01 (p < 0.001). Intact parathyroid hormone (iPTH) continuously normalized in all patients from 29 +/- 5 to 8 +/- 2 pmol/l (p < 0.001).

Wow , the drop in PTH is impressive!
I doubt a regular calcium supplement would be so effective in lowering PTH. The dose of elemental calcium isnt even that high.
I guess the added benefit comes from the fact that it lowers phosphate AND increases calcium at the same time.

Have you ever tried it ?

 

[Mauritio]

"AKG induces muscle hypertrophy, brown adipose tissue (BAT) thermogenesis, and white adipose tissue (WAT) lipolysis in vivo. We further found that AKG stimulates the adrenal release of adrenaline through 2-oxoglutarate receptor 1 (OXGR1) expressed in adrenal glands. Finally, by using both loss-of-function and gain-of-function mouse models, we showed that OXGR1 is essential for AKG-mediated exercise-induced beneficial metabolic effects. These findings reveal an unappreciated mechanism for the salutary effects of resistance exercise, using AKG as a systemically derived molecule for adrenal stimulation of muscle hypertrophy and fat loss."

Exercise-induced α-ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1-dependent adrenal activation - PubMed

Beneficial effects of resistance exercise on metabolic health and particularly muscle hypertrophy and fat loss are well established, but the underlying chemical and physiological mechanisms are not fully understood. Here, we identified a myometabolite-mediated metabolic pathway that is essential...

pubmed.ncbi.nlm.nih.gov

 

[Lokzo]

I’ve been taking 1200mg daily now for the past 5 days. I did notice an ammonia dump effect (via urine) which is good and I’ve also noticed more vivid dreams.

I can’t say I’ve “felt” the adrenaline release…

But I’m gonna take it for a month or so, and observe the effects. Had an amazing pump last night in the gym but that could’ve been because I haven’t trained in 5 days and have been eating like a pig with ***t loads of carbs.

 

[Mauritio]

I’ve been taking 1200mg daily now for the past 5 days. I did notice an ammonia dump effect (via urine) which is good and I’ve also noticed more vivid dreams.

I can’t say I’ve “felt” the adrenaline release…

But I’m gonna take it for a month or so, and observe the effects. Had an amazing pump last night in the gym but that could’ve been because I haven’t trained in 5 days and have been eating like a pig with ***t loads of carbs.

Nice ,I've read in this thread that it can be a precursor to NO ,which might explain the pump.

Calcium Alpha-ketoglutarate. A Calcium Supplement With Added Benefits?

While searching for the ideal calcium supplement I came across calcium alpha-ketoglutarate which I think has not been discussed on this forum yet and looks highly interesting. There is a study showing that calcium alpha-ketoglutarate extends lifespan and compresses morbidity in aging mice...

raypeatforum.com

 

[Vesi]

I’ve been taking 1200mg daily now for the past 5 days. I did notice an ammonia dump effect (via urine) which is good and I’ve also noticed more vivid dreams.

I can’t say I’ve “felt” the adrenaline release…

But I’m gonna take it for a month or so, and observe the effects. Had an amazing pump last night in the gym but that could’ve been because I haven’t trained in 5 days and have been eating like a pig with ***t loads of carbs.

Update on this?

 

[Smelly5]

Any update to your experience with AKG?? @Lokzo