Geneticist Links Chronic Fatigue To Mitochondria Dysfunction

[Such_Saturation]

Well, I think a question like @Texon asked might also be considered "entrapment" in any legal proceeding, since it could be seen as "soliciting" you for an answer, and is therefore more safe for offering a useful, informed opinion. Key word there being "opinion", like from one lay person to another: "X substance is supposed to help symptoms of Y disease according to studies, but you should read and decide for yourself", or similar.

I very, very seldom see anything that could be considered medical advice on this board, except by the most convoluted of logical stretching. People that actually give instructions on what to do and say unequivocally their advice will help or cure generally get told about it in short order.

But since you obviously really like mysterious and cryptic, you should take whatever opportunities you get to practice it, I guess.

In a similar vein, I have no experience with panquinone but know that kuinone has given a few of my online friends with CFS some improvement then problems. I guess it has to do with a ramping up of some bodily processes that other bodily processes can't cope with. My own experiences with kuinone have been pretty positive and I think it's helped me with stamina and energy, not to mention I think it's promoted some bone growth in my jaw...both times I've gone high dose for a couple of months my jaw has gotten subtly wider, which for me is a good thing. But there does seem to be a tipping point when it comes to helping with metabolism. More is not necessarily better over the long haul, and especially if your CFS symptoms are severe.

Of course, I don't think anybody can stop us from trying the stuff and writing experiences.

 

[HLP]

It was a very long journey for sure. I can remember being too tired to sit up properly in my chair in high school. I just thought it was normal. When I finished school and started working, I barely got through the day and would absolutely collapse when I got home from work. Interestingly I could sleep at any given moment in time which was a blessing for sure. Doctoring along the way was an absolute waste of time since my labs came back normal. Finally I was referred to a psychiatrist who believed I wasn't making anything physical up but all he had to offer was support and antidepressants since I'd already been seen by many specialists including internists, gynecologists and a number of naturopaths. I even wrote introductory letters to any new doctors I planned to see so that I would come off like a hypochondriac. Thankfully I had the support of a very patient and loving husband who knew I wasn't faking anything. The system just failed me. The exhaustion I dealt with was overwhelming with only a few good days out of the month, so most days were filled with sleeping off and on all day long. Looking back I made many mistakes with diet including drinking too much water and limiting sugar and salt to my own detriment. Needless to say I developed a poor relationship with food because I kept trying all different kinds of change in diet to see if I could feel better. My start in life likely wasn't the greatest neither. I was born three weeks early,wasn't breastfed at all and was given valium as a child for hyperactivity. The one thing I did manage to get as a child was massive amounts of sugar but this was combined with margarine and miracle whip in and on everything. Ouch. Finally in my late 40's I stepped outside the box and approached Lita Lee in Portland Oregon for help. Once I establish good health I was able to approach a doctor with enough strength and knowledge that hypothyroidism was the culprit and thankfully I got a prescription and haven't looked back. Following the basic outline of diet provided on this forum has also helped me get stronger and healthier. I hope this can help someone avoid living the same experience I did. Really, most of it was a real blur to me because I slept through most of it.

 

[whodathunkit]

@HLP, many thanks for the write-up. Really, really interesting! There seem to be a lot of parallels in our histories. I was never as "in the tank" as you with CFS, but symptoms got almost debilitating (although never quite) starting in my 30's, and I've always had energy problems from earliest childhood. I was also a three-weeks preemie and was not breastfed. Lot of processed food in the early years, but also a lot of sugar.

Do you know why you were born prematurely? My mother had preeclampsia, which all relates back to a lack of progesterone. She's always had symptoms of high estrogen and serotonin, even now when she's hitting her 80's.

I think your experiences can help people. Please keep sharing! :)

 

[HLP]

Not sure why I was born prematurely. My Mom died when she was 68 of bone cancer and she had been on Synthroid for quite some time. Her Mom died @ 39 and when I looked at old photos I noticed my Grandmother who I had never met, had fluid pooling in her ankles. She was not overweight neither. I can remember having all kinds of problems as a kid. Constipation for which I was given mineral oil on a regular basis. Interestingly I was very skinny during those years of CFS and I guess this was misleading to the doctors as well. Thankfully I did not self medicate with alcohol or cigarettes. I also "forced" myself to exercise, sometimes in tears. Something important to note was that my blood pressure was extremely low most of the time and my body temps were way below normal and I can remember doing a lot of sighing and yawning. Even breathing was an effort. I had two friends who also suffered with these same symptoms. They didn't get help and in time and both died from cancer. It's amazing that I was able to completely recover with no trace of fatigue and I am so grateful to be able to bounce out of bed to enjoy a full day's work without needing a nap. Thanks to Lita Lee and Ray Peat.

 

[Texon]

Dr Chandry in UK got temporarily banned for prescribing B12 against NHS 'NICE' guidelines, despite good evidence of the efficacy of his practice when he believed B12 deficiency was causing the problem. Despite 30 years of excellent records. There is not only ignorance in the medical profession but ingrained, well-defended bias and inertia, which results in actions tantamount to bullying those 'not in the gang'.

Well said.

 

[Lore]

"Chronic Fatigue Syndrome" = hypothyroidism. Fix cellular energy per the recommendations of Ray Peat and CFS goes away. The flu experienced by some in the beginning was enough to knock down their metabolism so that "Chronic Fatigue Syndrome" could set it. A huge stress like moving, or death in family can do the same thing.

Once again, just another case of all things hypothyroidism.

I totally agree, however, my understanding is coming from my research on "pathogens and diseases". Can't wait to connect the hypothyroid relationship. Just wanted to post this so I had a copy of this in my file here, for further research.

 

[Xisca]

self-injected hydroxocobalamine because I have to be very careful with methyl vitamins, donors, etc., if I don't want to be really miserable.

I am myself with methylcobalamine lozange, and great for me. I had heard it could be not so great, but I would like to know if it is possible to know before trying it, that methyl- is going to be bad. Hydroxo- better than cyano- anyway...
Did you have clues about the methylation, were you sure it was not for you and why, or you experimented and it did not work?

 

[Seeweed65]

Hi @whodathunkit

Have you ever had any success with sublingual Hydroxycobalamin?

 

[Texon]

I am myself with methylcobalamine lozange, and great for me. I had heard it could be not so great, but I would like to know if it is possible to know before trying it, that methyl- is going to be bad. Hydroxo- better than cyano- anyway...
Did you have clues about the methylation, were you sure it was not for you and why, or you experimented and it did not work?

I actually do take sublingual methyl B12 but not every day. I have to be careful with it. The reason for hydroxocobalamine and adenosyl forms is that they don't overload people with COMT snps with methyl groups. Too much methylation for people like me with homozygous COMT issues will have severe reactions due to dopamine and catecholamine overload. The only way to stop the reaction is to take niacin or niacinamide which act as methyl sinks. I can't go near methyl folate supps. One time my doc gave me a 'medical food' which was a prescription (imagine that) high dose (5 mgs) methyl folate supp. I dumped half the capsule and took the other half....once....I will never forget it. I told my wife, "This must be what dying feels like." It felt like every bit of my energy was draining into the ground. For me, methylation is a tough balancing act for sure. The event that may have triggered all this may have tryptophan poisoning in 1989 known as eosinophilia myalgia syndrome (EMS). A lot of people died from it, and one researcher said people who went through it are now genetically different. Guess that includes me.

 

[kyle]

Peat said in some interview b-vitamins were essential for some people recovering from trauma.

 

[freyasam]

First of all, "chronic fatigue" is not in the same universe as the inadequately named, shattering, and disabling Chronic Fatigue Syndrome.

Second, I've followed Peat's work for 6 years. TSH is 0.1. My CFS has not improved. So no, hypothyroidism is not always the cause of CFS.

 

[freyasam]

I'm not trying to be vague here, but the stack and how to manage it is a huge topic that would be prohibitively time-consuming for me to delineate right now. I debated on even mentioning it because I knew people would want to know about it. It's been so important to me, but at the same time I hope you understand what I'm saying. Trying to elucidate stuff like this with precision takes up a huge amount of time.

So what I will tell you is to go to this thread

"Biggest Loser" Contestants Regained Weight. Peat Perspective

And read post #147. Go from there. Reams has already been written on the topic of the stack I used, and by people much more knowledgeable than me. If you want to try it, what's already been written should be consumed and digested before attempting. Just if you go over to that other forum, please remember that it's set up for a specific purpose just like this board is. Lotta people over there are trying to resolve complex, seemingly intractable health problems. It's not about general health, and sometimes they can get a little [understandably] perturbed if people just looking to improve general health go and start asking time-consuming questions without reading up first. Be considerate and mindful, is I guess what I'm trying to say. And if you get something out of what you find there, maybe make a donation.

Everything after post #140 is gone! How disappointing! I'd love to hear more about how you healed your ME/CFS.

 

[mostlylurking]

First of all, "chronic fatigue" is not in the same universe as the inadequately named, shattering, and disabling Chronic Fatigue Syndrome.

Second, I've followed Peat's work for 6 years. TSH is 0.1. My CFS has not improved. So no, hypothyroidism is not always the cause of CFS.

I am hypothyroid and have taken thyroid meds for 40 years. I'm taking 150 mg natural desiccated thyroid currently. My TSH was .021 when I was at my sickest with raging rheumatoid arthritis and inadequate thyroid supplementation.

I'm saying this because from reading your comment above I interpret that because your TSH is 0.1 you think that you can't be hypothyroid. Maybe I misunderstand your post.

Sometimes the pituitary decides to call it a day and stops putting out TSH even though your thyroid hormones are in the ditch and you need help really really badly. My 84 year old endocrinologist had seen it before so he didn't pay it any attention and treated me anyway.