I have always thought exercise increases inflammatory markers, and the increase in inflammation doesn't really level off in time; but the studies I have read say the contrary. What do you think? I am asking because I have a chronic inflammatory disease and I am avoiding sports and exercise because of that.
Journal of the American College of Cardiology
Volume 45, Issue 10, 17 May 2005, Pages 1563-1569
State-of-the-Art Paper
The Effects of Physical Activity on Serum C-Reactive Protein and Inflammatory Markers: A Systematic Review
Author links open overlay panelChristosKasapisMD⁎Paul D.ThompsonMD(FACC)†
Redirecting
Conclusions
There is a short-term, transient increase in serum CRP after strenuous exercise, produced by an exercise-induced APR, mediated by the cytokine system and mainly IL-6. Exercise training may blunt this response, whereas there is also a homeostatic, anti-inflammatory counter-APR after strenuous exercise. Chronic physical activity reduces resting CRP levels by multiple mechanisms, including a decrease in cytokine production by adipose tissue, skeletal muscles, endothelial and blood mononuclear cells, improved endothelial function and insulin sensitivity, and possibly an antioxidant effect.
(APR): Acute Phase Response
**************************** ****************************
Effect of exercise training on C reactive protein: a systematic review and meta-analysis of randomised and non-randomised controlled trials
Author affiliations
Abstract
Purpose C-reactive protein (CRP) is a marker of chronic systemic inflammation frequently used in cardiovascular disease risk assessment. The purpose of this meta-analysis was to provide a quantitative estimate of the magnitude of change in CRP following participation in physical exercise interventions.
Methods All studies included in the meta-analysis were peer reviewed and published in English. Human participants were assigned to a non-exercise comparison group or exercise training group, with the intervention lasting ≥2 weeks. CRP levels were measured at baseline, during and/or after completion of the exercise training programme. Random-effects models were used to aggregate a mean effect size (ES), 95% CIs and potential moderators.
Results 83 randomised and non-randomised controlled trials met the inclusion criteria and resulted in 143 effects (n=3769). The mean ES of 0.26 (95% CI 0.18 to 0.34, p<0.001) indicated a decrease in CRP following exercise training. A decrease in body mass index (BMI; β=1.20, SE=0.25, p<0.0001) and %Fat (β=0.76, SE=0.21, p=0.0002) were associated with a decrease in CRP, independently accounting for 11.1% and 6.6% of the variation in response, respectively. Exercise training led to a greater reduction in CRP when accompanied by a decrease in BMI (ES=0.38, 95% CI 0.26 to 0.50); however, a significant improvement in CRP occurred in the absence of weight loss (ES=0.19, 95% CI 0.10 to 0.28; both p<0.001).
Conclusions These results suggest that engaging in exercise training is associated with a decrease in CRP levels regardless of the age or sex of the individual; however, greater improvements in CRP level occur with a decrease in BMI or %Fat.
Effect of exercise training on C reactive protein: a systematic review and meta-analysis of randomised and non-randomised controlled trials
Fedewa MV, Hathaway ED, Ward-Ritacco CL
Effect of exercise training on C reactive protein: a systematic review and meta-analysis of randomised and non-randomised controlled trials
Br J Sports Med 2017;51:670-676.
**************************** ****************************
Effect of exercise training on plasma levels of C-reactive protein in healthy adults: the HERITAGE Family Study
Timo A. Lakka Hanna-Maaria Lakka Tuomo Rankinen Arthur S. Leon D.C. Rao James S. Skinner Jack H. Wilmore Claude Bouchard
European Heart Journal, Volume 26, Issue 19, 1 October 2005, Pages 2018–2025, Effect of exercise training on plasma levels of C-reactive protein in healthy adults: the HERITAGE Family Study
Published:
29 June 2005
Abstract
Purpose C-reactive protein (CRP) is a marker of chronic systemic inflammation frequently used in cardiovascular disease risk assessment. The purpose of this meta-analysis was to provide a quantitative estimate of the magnitude of change in CRP following participation in physical exercise interventions.
Methods All studies included in the meta-analysis were peer reviewed and published in English. Human participants were assigned to a non-exercise comparison group or exercise training group, with the intervention lasting ≥2 weeks. CRP levels were measured at baseline, during and/or after completion of the exercise training programme. Random-effects models were used to aggregate a mean effect size (ES), 95% CIs and potential moderators.
Results 83 randomised and non-randomised controlled trials met the inclusion criteria and resulted in 143 effects (n=3769). The mean ES of 0.26 (95% CI 0.18 to 0.34, p<0.001) indicated a decrease in CRP following exercise training. A decrease in body mass index (BMI; β=1.20, SE=0.25, p<0.0001) and %Fat (β=0.76, SE=0.21, p=0.0002) were associated with a decrease in CRP, independently accounting for 11.1% and 6.6% of the variation in response, respectively. Exercise training led to a greater reduction in CRP when accompanied by a decrease in BMI (ES=0.38, 95% CI 0.26 to 0.50); however, a significant improvement in CRP occurred in the absence of weight loss (ES=0.19, 95% CI 0.10 to 0.28; both p<0.001).
Conclusions These results suggest that engaging in exercise training is associated with a decrease in CRP levels regardless of the age or sex of the individual; however, greater improvements in CRP level occur with a decrease in BMI or %Fat.
Journal of the American College of Cardiology
Volume 45, Issue 10, 17 May 2005, Pages 1563-1569
State-of-the-Art Paper
The Effects of Physical Activity on Serum C-Reactive Protein and Inflammatory Markers: A Systematic Review
Author links open overlay panelChristosKasapisMD⁎Paul D.ThompsonMD(FACC)†
Redirecting
Conclusions
There is a short-term, transient increase in serum CRP after strenuous exercise, produced by an exercise-induced APR, mediated by the cytokine system and mainly IL-6. Exercise training may blunt this response, whereas there is also a homeostatic, anti-inflammatory counter-APR after strenuous exercise. Chronic physical activity reduces resting CRP levels by multiple mechanisms, including a decrease in cytokine production by adipose tissue, skeletal muscles, endothelial and blood mononuclear cells, improved endothelial function and insulin sensitivity, and possibly an antioxidant effect.
(APR): Acute Phase Response
**************************** ****************************
Effect of exercise training on C reactive protein: a systematic review and meta-analysis of randomised and non-randomised controlled trials
Author affiliations
Abstract
Purpose C-reactive protein (CRP) is a marker of chronic systemic inflammation frequently used in cardiovascular disease risk assessment. The purpose of this meta-analysis was to provide a quantitative estimate of the magnitude of change in CRP following participation in physical exercise interventions.
Methods All studies included in the meta-analysis were peer reviewed and published in English. Human participants were assigned to a non-exercise comparison group or exercise training group, with the intervention lasting ≥2 weeks. CRP levels were measured at baseline, during and/or after completion of the exercise training programme. Random-effects models were used to aggregate a mean effect size (ES), 95% CIs and potential moderators.
Results 83 randomised and non-randomised controlled trials met the inclusion criteria and resulted in 143 effects (n=3769). The mean ES of 0.26 (95% CI 0.18 to 0.34, p<0.001) indicated a decrease in CRP following exercise training. A decrease in body mass index (BMI; β=1.20, SE=0.25, p<0.0001) and %Fat (β=0.76, SE=0.21, p=0.0002) were associated with a decrease in CRP, independently accounting for 11.1% and 6.6% of the variation in response, respectively. Exercise training led to a greater reduction in CRP when accompanied by a decrease in BMI (ES=0.38, 95% CI 0.26 to 0.50); however, a significant improvement in CRP occurred in the absence of weight loss (ES=0.19, 95% CI 0.10 to 0.28; both p<0.001).
Conclusions These results suggest that engaging in exercise training is associated with a decrease in CRP levels regardless of the age or sex of the individual; however, greater improvements in CRP level occur with a decrease in BMI or %Fat.
Effect of exercise training on C reactive protein: a systematic review and meta-analysis of randomised and non-randomised controlled trials
Fedewa MV, Hathaway ED, Ward-Ritacco CL
Effect of exercise training on C reactive protein: a systematic review and meta-analysis of randomised and non-randomised controlled trials
Br J Sports Med 2017;51:670-676.
**************************** ****************************
Effect of exercise training on plasma levels of C-reactive protein in healthy adults: the HERITAGE Family Study
Timo A. Lakka Hanna-Maaria Lakka Tuomo Rankinen Arthur S. Leon D.C. Rao James S. Skinner Jack H. Wilmore Claude Bouchard
European Heart Journal, Volume 26, Issue 19, 1 October 2005, Pages 2018–2025, Effect of exercise training on plasma levels of C-reactive protein in healthy adults: the HERITAGE Family Study
Published:
29 June 2005
Abstract
Purpose C-reactive protein (CRP) is a marker of chronic systemic inflammation frequently used in cardiovascular disease risk assessment. The purpose of this meta-analysis was to provide a quantitative estimate of the magnitude of change in CRP following participation in physical exercise interventions.
Methods All studies included in the meta-analysis were peer reviewed and published in English. Human participants were assigned to a non-exercise comparison group or exercise training group, with the intervention lasting ≥2 weeks. CRP levels were measured at baseline, during and/or after completion of the exercise training programme. Random-effects models were used to aggregate a mean effect size (ES), 95% CIs and potential moderators.
Results 83 randomised and non-randomised controlled trials met the inclusion criteria and resulted in 143 effects (n=3769). The mean ES of 0.26 (95% CI 0.18 to 0.34, p<0.001) indicated a decrease in CRP following exercise training. A decrease in body mass index (BMI; β=1.20, SE=0.25, p<0.0001) and %Fat (β=0.76, SE=0.21, p=0.0002) were associated with a decrease in CRP, independently accounting for 11.1% and 6.6% of the variation in response, respectively. Exercise training led to a greater reduction in CRP when accompanied by a decrease in BMI (ES=0.38, 95% CI 0.26 to 0.50); however, a significant improvement in CRP occurred in the absence of weight loss (ES=0.19, 95% CI 0.10 to 0.28; both p<0.001).
Conclusions These results suggest that engaging in exercise training is associated with a decrease in CRP levels regardless of the age or sex of the individual; however, greater improvements in CRP level occur with a decrease in BMI or %Fat.
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