It may very well be that ozone is the answer.My understanding is that when the ozone gets into circulation, it will contact and destroy any circulating microbes before it becomes metabolized. I believe this to be so, since I had used many anti-fungal treatments, essential oils included, with very minimal success, and did not eradicate the fungus until I used the ozone RIs. I am sure that some microbes will hide in deep tissue, etc., but that is why it is not a once and done treatment. Mine took two weeks with monthly maintenance, others may take longer. Osmose is doing the RIs, and you may want to ask him about his experience.
Whatever works should have me seeing improvements in four areas:
1. Urine foaming will be gone.
2. Blood pressure will go down.
3. My wbc and neutrophils will go down.
4. My nightly spO2 chart (see above image 7 posts up) will see more greens than reds, with few or no spO2 drops because there is little phagocytic activity, and much less oxygen demand from it.